Babak Javida - 清华大学

个人简介

2011- present Tenure-track PI, Centre for Infectious Diseases, Tsinghua University School of Medicine 2012- present Visiting Senior Research Fellow, University of Cambridge Department of Medicine 2008- present Honorary Consultant Physician, Addenbrooke’s Hospital, Cambridge 2007-2011 MRC (UK) Clinician Scientist Fellow, Harvard School of Public Health 2004-2007 Clinical Lecturer in Infectious Diseases, University of Cambridge Department of Medicine 2001-2004 PhD, Cambridge Institute for Medical Research, University of Cambridge 1998-2001 Medical Resident 1995-1997 MB Chir, University of Cambridge Clinical School 1992-1995 BA, Gonville & Caius College, Cambridge

研究领域

Javid 实验室研究的主要病原为结核分枝杆菌，该病原目前仍是中国乃至世界范围内最重要的病原微生物。Javid 实验室有两个基本的研究方向，即基因翻译调控和结核分枝杆菌的病理生理研究。 1. 结核分枝杆菌抗生素耐药性的分子机制； 2. 分枝杆菌、人体和包括果蝇在内的模式生物的翻译保真度调控； 3. 机体对于结核分枝杆菌的保护性免疫的构成； 4. 开发加速结核病治疗周期的新疗法。

近期论文

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1. Babak Javid# and M.Estee Torok (2016). Whole-genome sequencing for the diagnosis of drug-resistant tuberculosis. The Lancet Infectious Diseases. 16(1):17. #corresponding author 2. Tianqi Leng, Miaomiao Pan, Xu Xin and Babak Javid# (2015). Translational misreading in Mycobacterium smegmatis increases in stationary phase. Tuberculosis. 95(6):678-681. 3. Hao Li, Masood ur Rehman Kayani, Yunting Gu, Xiaobo Wang, Ting Zhu, Hongfei Duan, Yifeng Ma, Hairong Huang# and Babak Javid#(2015). Transmitted extended-spectrum extensively drug-resistant tuberculosis in Beijing, China, with discordant whole-genome sequencing analysis results. Journal of Clinical Microbiology. 53(8): 2871-2874. 4.Junhao Zhu and Babak Javid# (2015). Tuberculosis: hey there lonely guy! Molecular Cell. 57(2): 951-952. 5.Claudio U Koser, Babak Javid, Kathleen Lidell, Matthew J Ellington, Silke Feuerriegel, Stefan Niemann, Nicholas M Brown, William J Burman, Ibrahim Abubakar, Nazir A Ismail, David Moore, Sharon J Peacock and M Estee Torok(2015). Drug-resistance mechanism and tuberculosis drugs. The Lancet. 385(9965):305-307. 6.Lluis Ribas de Pouplana, Manuel A S Santos, Junhao Zhu, Philip J Farabaugh and Babak Javid#(2014). Protein mistranslation: Friend of foe? Trends in Biochemical Sciences. 39(8):355-362. 7. Melody Toosky and Babak Javid# (2014). Novel therapeutics and diagnostics for drug-resistant tuberculosis. British Medical Bulletin. 110(1):129-140. 8. Babak Javid#, Flavia Sorrentino, Wen Zheng, Melody Toosky, Jessica T. Pinkham, Miaomiao Pan, Nina Jain, Padraig Deighand & Eric J. Rubin (2014). Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance. PNAS. 111(3): 1132-1137. 9. Xiaobo Wang, Hao Li, Guanglu Jiang, Liping Zhao, Yifeng Mao, Babak Javid and Hairong Huang(2014). Prevalence and drug-resistance of non-tuberculous mycobacteria in Northern China, 2008-2011. Emerging Infectious Diseases. 20(7):1252-1253. 10.Sharon Y Wong, Babak Javid, Balahsubrahmanyam Adepalli, Grzegorz Piszczek, Michael B Strader, Patrick A Limbach, Clifton E Barry III (2013). Functional Role of Methylation of G518 of 16S rRNA 530 loop by GidB in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 57(12):6311-6318.