姚骏 - 清华大学 - 生命科学学院

个人简介

1999, 南京大学生物科学与技术系学士 2001, 南京大学生物科学与技术系硕士 2007, 美国宾夕法尼亚州立大学博士 2007-2011 美国霍华德休斯医学研究所，威斯康星大学 Postdoctoral Research Associate 2011-2013 美国萨克生物学研究所 Research Associate 2013- 清华大学生命科学学院助理教授、副教授

研究领域

课题组致力于从遗传学、分子和神经环路等多个维度阐明情感障碍（双相情感障碍和抑郁症）的发病机理。情感障碍是发病率、遗传率和自杀率最高的一类疾病，但目前这类疾病的发病机理仍不清楚，临床药物也存在很多限制和副作用。课题组的研究主要基于多能干细胞(iPSC)、3D类脑和小鼠模型，采用膜片钳和在体电生理、超高分辨率显微成像、动物行为学、光遗传、冷冻电镜以及多种基因测序手段，从病人iPSC分化的神经元和3D类脑中遴选出疑似与发病相关的关键基因或分子通路，结合类脑和小鼠模型，探究：1）该通路导致疾病发生的分子水平机理；2）其产生致病影响的小鼠关键脑区和神经环路；3）在人类神经元中受不同易感基因调控的遗传学机制。

近期论文

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Wang QW, Wang YH, Wang B, Chen Y, Lu SY, Yao J. Synaptotagmin-7-mediated activation of spontaneous NMDAR currents is disrupted in bipolar disorder susceptibility variants. PLoS Biol. 2021 Jul 6;19(7):e3001323. doi: 10.1371/journal.pbio.3001323. Lu SY, Fu CL, Liang L, Yang B, Shen W, Wang QW, Chen Y, Chen YF, Liu YN, Zhu L, Zhao J, Shi W, Mi S, Yao J. miR-218-2 regulates cognitive functions in the hippocampus through complement component 3-dependent modulation of synaptic vesicle release. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2021770118. doi: 10.1073/pnas.2021770118. Chen Y, Wang YH, Zheng Y, Li M, Wang B, Wang QW, Fu CL, Liu YN, Li X, Yao J. Synaptotagmin-1 interacts with PI(4,5)P2 to initiate synaptic vesicle docking in hippocampal neurons.Cell Rep. 2021 Mar 16;34(11):108842. doi: 10.1016/j.celrep.2021.108842. Wang QW, Lu SY, Liu YN, Chen Y, Wei H, Shen W, Chen YF, Fu CL, Wang YH, Dai A, Huang X, Gage FH, Xu Q, Yao J. Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31438-31447. doi: 10.1073/pnas.2016416117. Epub 2020 Nov 23. Shen W, Wang QW, Liu YN, Marchetto MC, Linker S, Lu SY, Chen Y, Liu C, Guo C, Xing Z, Shi W, Kelsoe JR, Alda M, Wang H, Zhong Y, Sui SF, Zhao M, Yang Y, Mi S, Cao L, Gage FH, Yao J. Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4392-4399. doi: 10.1073/pnas.1918165117. Epub 2020 Feb 10. Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, Yao J. CRISPR interference-based specific and efficient gene inactivation in the brain. Nat Neurosci. 2018 Mar;21(3):447-454. doi: 10.1038/s41593-018-0077-5. Epub 2018 Feb 5. Erratum in: Nat Neurosci. 2018 Mar 15. Liu YN, Lu SY, Yao J. Application of induced pluripotent stem cells to understand neurobiological basis of bipolar disorder and schizophrenia.Psychiatry Clin Neurosci. 2017 Sep;71(9):579-599. doi: 10.1111/pcn.12528. Epub 2017 May 2. Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames TJ, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Ødegaard KJ, McCarthy MJ, Zandi PP, PBDS, Mi S, Brennand KJ, Kelsoe JR, Gage FH, Yao J. Differential Responses to Lithium in Hyperexcitable Neurons from Bipolar Patients. Nature. 2015 Nov 5;527(7576):95-9. doi: 10.1038/nature15526. Epub 2015 Oct 28. Yu DX, Di Giorgio DP, Yao J, Marchetto MC, Brennand K, Wright R, Mei A, McHenry L, Lisuk D, Grasmik J, Silberman P, Silberman G, Jappelli R, Gage FH (2014). Modeling hippocampal neurogenesis using human pluripotent stem cells. Stem Cell Reports. 2014 Feb 27;2(3):295-310. doi: 10.1016/j.stemcr.2014.01.009. eCollection 2014 Mar 11. Yao J, Kwon SE, Gaffaney JD, Dunning FM, Chapman ER (2012). Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles. Nature Neuroscience. 15(2): 243-249. Yao J, Gaffaney JD, Kwon SE, Chapman ER (2011). Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. Cell. 147(3):666-77. Yao J, Mu Y, Gage FH (2012). Neural stem cells: mechanisms and modeling. Protein & Cell. 3(4): 251-261. (Review) Wu Y, Gu Y, Morphew MK, Yao J, Yeh FL, Dong M, Chapman ER (2012). All three components of the neuronal SNARE complex contribute to secretory vesicle docking in PC12 cells. Journal of Cell Biology. 198(3):323-30. Yeh FL, Dong M, Yao J, Tepp WH, Lin G, Johnson EA, Chapman ER (2010). SV2 mediates entry of tetanus neurotoxin into central neurons. PLoS Pathogens. 6(11): e1001207. Yuan X, Yao J, Norris D, Tran DD, Bram RJ, Chen G, Luscher B (2008). Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors. Molecular and Cellular Neuroscience. 38(2):277-289. Deng, L.*, Fang, C., Dong, N., Luscher, B., Chen G. Sequential postsynaptic maturation governs the temporal order of GABAergic and glutamatergic synaptogenesis in rat embryonic cultures. Journal of Neuroscience. 2007 Oct 3;27(40):10860-9. (*Equal contribution) Yao,J., Qi, J. S., and Chen, G. Actin-dependent activation of presynaptic silent synapses contributes to long-term synaptic plasticity in developing hippocampal neurons. Journal of Neuroscience. 2006 Aug 2;26(31):8137-47. Qi, J., Yao, J., Fang, C., Luscher, B., and Chen G (2006). Downregulation of Tonic GABA Currents Following Epileptogenic Stimulation of Rat Hippocampal Cultures. Journal of Physiology. 577(2): 579-590.