个人简介
2018年-至今： 清华大学生命学院 助理教授、副教授
2018年-至今： 清华-北大生命联合中心 研究员
2018年-至今： 结构生物学高精尖创新中心 研究员
2017－2018年： 英国牛津大学粒子成像中心 Senior Research Associate
2013－2017年： 英国牛津大学粒子成像中心 博士后
2009－2012年： 德国哥廷根大学生物物理系 博士
2006－2008年： 德国斯图加特大学物理系 硕士
2002－2006年： 武汉大学应用物理系 学士
研究领域
1. 高分辨冷冻电镜断层成像（cryo-ET）方法。高分辨cryo-ET是通过收集三维断层图像，再使用子断层图像平均法进行结构解析的前沿结构生物学方法。Cryo-ET擅长对柔性巨型分子机器、细菌、细胞进行成像和蛋白结构解析，获得具生理意义的原位结构，是结构生物学的下一个突破。
2. 新发囊膜病毒的组装及在细胞中复制活动的结构与功能。由于形态不均一，囊膜病毒的原位结构解析颇具挑战。我们使用cryo-ET解析全病毒结构，并在细胞中直接观测病毒生命活动的原位结构，希望揭示囊膜病毒的组装机制，并揭秘它们在细胞中的生命活动。最终目的是找到病毒的弱点，并为抗体、疫苗设计提供新思路。
近期论文
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Chaoyu Wang; Ruoshi Zhang; Jia He; Lvshan Yu; Xinyan Li; Junxia Zhang; Sai Li; Conggang Zhang; Jonathan C. Kagan; Jeffrey M. Karp; Rui Kuai; Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated antitumour immunity, Nat Commun 2023, 14: 3877;
Yutong Song#; Hangping Yao#; Nanping Wu#; Jialu Xu#; Zheyuan Zhang#; Cheng Peng; Shibo Li; Weizheng Kong; Yong Chen; Miaojin Zhu; Jiaqi Wang; Danrong Shi; Chongchong Zhao; Xiangyun Lu; Martín Echavarría Galindo; Sai Li; In situ architecture and membrane fusion of SARS-CoV-2 Delta variant, PNAS (accepted)
Dali Wang#; Jiaxuan Li#; Lei Wang; Yipeng Cao; Bo Kang; Xiangfei Meng; Sai Li*; Chen Song*; Toward Atomistic Models of Intact SARS-CoV-2 via Martini Coarse-Grained Molecular Dynamics Simulations, Quantitative Biology (accepted)
Ye Hong#; Yutong Song#; Zheyuan Zhang; Sai Li; Cryo-electron tomography: the resolution revolution and a surge of in situ virological discoveries, Annual Review of Biophysics, 2023, 52(1):14.1–14.22;
Julio Rey Ramirez; Peter Rautek; Ciril Bohak; Ond?ej Strnad; Zheyuan Zhang; Sai Li; Ivan Viola; Wolfgang Heidrich; GPU Accelerated 3D Tomographic Reconstruction and Visualization from Noisy Electron Microscopy Tilt-Series, IEEE TVCG, 2022;
Ngan Nguyen#; Ciril Bohak#; Dominik Engel; Peter Mindek; Ondrej Strnad; Peter Wonka; Sai Li; Timo Ropinski; Ivan Viola; Finding Nano-?tzi: Cryo-Electron Tomography Visualization Guided by Learned Segmentation, IEEE TVCG, 2022, PP: 1-18;
Sai Li; Cryo-electron tomography of enveloped viruses, Trends in Biochemical Sciences, 2022; 47(2): 173-186;
Shulin Li; Rui Yan; Jialu Xu; Shiqun Zhao; Xinyu Ma; Qiming Sun; Min Zhang; Ying Li; Jun-Jie Gogo Liu; Liangyi Chen; Sai Li; Ke Xu; Liang Ge; A new type of ERGIC-ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis, Cell Research, 2022, 32(2):119-138;
Joel D. Allen; Himanshi Chawla; Firdaus Samsudin; Lorena Zuzic; Aishwary Tukaram Shivgan; Yasunori Watanabe; Wan-ting He; Sean Callaghan; Ge Song; Peter Yong; Philip Brouwer; Yutong Song; Yongfei Cai; Helen M. E. Duyvesteyn; Tomas Malinauskas; Joeri Kint; Paco Pino; Maria J. Wurm; Martin Frank; Bing Chen; David I. Stuart; Rogier W. Sanders; Raiees Andrabi; Dennis R. Burton; Sai Li; Peter J. Bond*; Max Crispin*; Site-specific steric control of SARS-CoV-2 spike glycosylation, Biochemistry, 2021, 60(27): 2153-2169;
Xiaohui Ju; Yunkai Zhu; Yuyan Wang; Jingrui Li; Jiaxing Zhang; Mingli Gong; Wenlin Ren; Sai Li; Jin Zhong; Qiangfeng Cliff Zhang; Rong Zhang; Qiang Ding; A novel cell culture system modeling the SARS-CoV-2 life cycle, PLoS Pathogens, 2021, 17(3):e1009439;
Hangping Yao#; Yutong Song#; Yong Chen#; Nanping Wu#; Jialu Xu#; Chujie Sun; Jiaxing Zhang; Tianhao Weng; Zheyuan Zhang; Zhigang Wu; Linfang Cheng; Danrong Shi; Xiangyun Lu; Jianlin Lei; Max Crispin; Yigong Shi; Lanjuan Li*; Sai Li*; Molecular architecture of the SARS-CoV-2 virus, Cell, 2020 183(3):730-738;
Alexandra Serris; Robert Stass; Eduardo A. Bignon; Nicolas A. Muena; Jean-Claude Manuguerra; Rohit K. Jangra; Sai Li; Kartik Chandran; Nicole Tischler; Juha T. Huiskonen; Felix A. Rey*; Pablo Guardado-Calvo*; The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism, Cell, 2020, 183(2):442-456;
Ying Liu#; Yutong Song#; Siyu Zhang; Min Diao; Shanjin Huang; Sai Li; Xu Tan; PSGL-1 inhibits HIV-1 infection by restricting actin dynamics and sequestering HIV envelope proteins, Cell Discovery, 2020, 6(1):53;
Yanqing Zhang#; Sai Li#; Xuechen Zhu#; Gaoxingyu Huang#; Chao Zeng#; Qifan Wang; Kunpeng Wang; Qiang Zhou; Wusheng Zhang; Guangwen Yang; Minhao Liu; Qinghua Tao; Jianlin Lei; Yigong Shi; Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex, Cell Research, 2020, 30(6):532-540;
Xiaoling Wu; Hua Yue; Yuanyu Zhang; Xiaoyong Gao; Xiaoyang Li; Licheng Wang; Yufei Cao; Miao Hou; Haixia An; Lin Zhang*; Sai Li*; Jingyuan Ma; He Lin; Yanan Fu; Hongkai Gu; Wenyong Lou; Wei Wei*; Richard N. Zare; Jun Ge*; Packaging and delivering enzymes by amorphous metal-organic frameworks, Nature Communications, 2019, 10(1):5165;
Kamel El Omari; Sai Li; Abhay Kotecha; Thomas S Walter; Eduardo Andres Bignon; Karl Harlos; Pentti Somerharju; Felix De Haas; Daniel K. Clare; Mika Molin; Felipe Hurtado; Mengqiu Li; Jonathan M. Grimes; Dennis H. Bamford; Nicole D. Tischler; Juha T. Huiskonen; David I. Stuart; Elina Roine; The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins, Nature Communications, 2019, 10(1):846;
Yasunori Watanabe; Jayna Raghwani; Joel D. Allen; Gemma E. Seabright; Sai Li; Felipe Moser; Juha T. Huiskonen; Thomas Strecker; Thomas A. Bowden; Max Crispin; Structure of the Lassa virus glycan shield provides a model for immunological resistance, PNAS, 2018, 115(28):7320-7325;
Steinar Halldorsson#; Sai Li#; Mengqiu Li; Karl Harlos; Thomas A. Bowden; Juha T. Huiskonen; Shielding and activation of a viral membrane fusion protein, Nature Communications, 2018, 9(1):349;
Ilona Rissanen; Robert Stass; Antra Zeltina; Sai Li; Jussi Hepojoki; Karl Harlos; Robert J. C. Gilbert; Juha T. Huiskonen; Thomas A. Bowden; Structural Transitions of the Conserved and Metastable Hantaviral Glycoprotein Envelope, Journal of Virology, 2017, 91(21):e00378-17;
Sai Li; Ilona Rissanen; Antra Zeltina; Jussi Hepojoki; Jayna Raghwani; Karl Harlos; Oliver G. Pybus; Juha T. Huiskonen; Thomas A. Bowden; A Molecular-Level Account of the Antigenic Hantaviral Surface, Cell Reports, 2016, 15(5):959-967;
Sai Li; Zhaoyang Sun; Rhys Pryce; Marie-Laure Parsy; Sarah K Fehling; Katrin Schlie; C Alistair Siebert; Wolfgang Garten; Thomas A Bowden; Thomas Strecker; Juha T Huiskonen; Acidic pH-Induced Conformations and LAMP1 Binding of the Lassa Virus Glycoprotein Spike, PLoS Pathogens, 2016, 12(2):e1005418;
Juha T Huiskonen; Marie-Laure Parsy; Sai Li; David Bitto; Max Renner; Thomas A Bowden; Averaging of Viral Envelope Glycoprotein Spikes from Electron Cryotomography Reconstructions using Jsubtomo, Jove-Journal of Visualized Experiments, 2014, (92):e51714;
Sai Li#; Christian Sieben#; Kai Ludwig; Chris T H?fer; Salvatore Chiantia; Andreas Herrmann; Frederic Eghiaian, Iwan A.T. Schaap; pH-Controlled Two-Step Uncoating of Influenza Virus, Biophysical Journal, 2014, 106(7):1447-56;
Eberhard Wuenn; Joerg Hosch; Sai Li; Iwan A.T. Schaap; Tobias Schleuss; Super Hydrophobic PES Membrane and its Application in Biomedical Industry, Procedia Engineering, 2012, 44:449-450;
Schanila Nawaz; Paula Sánchez; Kai Bodensiek; Sai Li; Mikael Simons; Iwan A T Schaap; Cell Visco-Elasticity Measured with AFM and Optical Trapping at Sub-Micrometer Deformations, PLoS One, 2012, 7(9):e45297;
Ursula Fünfschilling; Wolf J. Jockusch; Nandhini Sivakumar; Wiebke M?bius; Kristina Corthals; Sai Li; Susanne Quintes; Younghoon Kim; Iwan A. T. Schaap; Jeong-Seop Rhee; Klaus-Armin Nave; Gesine Saher; Critical Time Window of Neuronal Cholesterol Synthesis during Neurite Outgrowth, Journal of Neuroscience, 2012, 32(22):7632-45;
Sai Li; Frederic Eghiaian; Christian Sieben; Andreas Herrmann; Iwan A.T. Schaap; Bending and Puncturing the Influenza Lipid Envelope, Biophysical Journal, 2011, 100(3):637-645;
Felix Hoos; Todd Meyrath; Sai Li; Bernd Braun; Harald Giessen; Femtosecond 5-W Yb:KGW slab laser oscillator pumped by a single broad-area diode and its application as supercontinuum source, Applied Physics B, 2009, 96(1):5-10;
Felix Hoos; Sai Li; Todd Meyrath; Bernd Braun; Harald Giessen; Thermal lensing in an end-pumped Yb:KGW slab laser with high power single emitter diodes, Optics Express, 2008, 16(9):6041-9;
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