陈柱成 - 清华大学 - 生命科学学院

个人简介

1994-1998年南开大学本科 1998-2001年北京大学硕士 2001-2003年纽约大学硕士 2003-2008年康奈尔大学博士 2008-2011年德州大学西南医学中心博士后 2011-至今清华大学生命学院副教授、教授

研究领域

DNA紧密缠绕组蛋白形成核小体。核小体是染色质的基本重复单元，是表观遗传的物质基础。然而，核小体的组装和紧密染色质的形成阻碍DNA遗传信息的读取。DNA甲基化、组蛋白修饰、核小体排布以及异染色质结构等表观遗传机制是解码遗传信息的关键，在基因转录、细胞命运决定以及人类疾病等方面起着重要作用。我们实验室主要以生物物理方法，结合生物化学以及其他手段，研究染色质调控因子的结构、工作机理以及生物学功能。我们的工作阐明了染色质重塑发生的机理，提出了染色质重塑的“DNA波”模型；我们解析了多个SWI/SNF家族超大染色质重塑复合物的高分辨结构，揭示其组装和识别核小体的机理，为相关基因突变的致病机理提供了理论框架；我们阐明了染色质重塑蛋白的活性调控机理，为染色质重塑蛋白应答染色质特征，调控染色质结构提供了理论框架。

近期论文

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Yuan J#, Chen K#, Zhang W. Chen Z. Structure of human PBAF chromatin remodeling complex bound to a nucleosome Nature, 605(7908):166-171, 2022 Qu K#, Chen K#, Wang H#, Li X*, Chen Z*. Structure of the NuA4 acetyltransferase complex bound to the nucleosome. Nature, 2022. Wang L#, Chen K#, Chen Z* Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome Nature Comm. 12 (1):4058, 2021 He Z#, Chen K#, Ye Y#, Chen Z* Structure of the SWI/SNF complex bound to the nucleosome and insights into the functional modularity Cell Discovery. 7(1): 28, 2021 Li L, Yan L, Chen Z. Reply to: Histone dynamics play a critical role in SNF2h-mediated nucleosome sliding. Nat. Struct. Mol. Biol. 28(7):552-553, 2021. Pan H, Guan R, Zhao R, Ou G, Chen Z. Mechanistic insights into central spindle assembly mediated by the centralspindlin complex. PNAS 118(40): e2112039118, 2021. Yan L, and Chen Z*. A Unifying Mechanism of DNA Translocation Underlying Chromatin Remodeling. Trends Biochem. Sci. 45(3):217-227, 2020.（invited review） Chen M#, Pan H#, Sun L#, Shi P#, Zhang Y, Li L, Huang Y, Chen J, Jiang P, Fang X, Wu C, Chen Z*. Structure and regulation of human epithelial cell transforming 2 protein. PNAS 117(2):1027-1035, 2020. Ye Y#, Wu H#, Chen K, Clapier CR, Verma N, Zhang W, Deng H, Cairns BR*, Gao N*, Chen Z*. Structure of the RSC complex bound to the nucleosome. Science, 366(6467):838-843, 2019 Yan L#, Wu H#, Li X, Gao N*, Chen Z* Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling Nat. Struct. Mol. Biol. 26(4):258-266, 2019 Li M#, Xia X#, Tian Y#, Jia Q#, Liu X#, Ying L, Li M*, Li X* Chen Z*. Mechanism of DNA translocation underlying chromatin remodeling by Snf2 Nature, 567(7748): 409-413, 2019. Huang H, Luo Z, Qi S, Huang J, Xu P, Wang X, Gao L, Li F, Wang J, Zhao W, Gu W, Chen Z, Dai L, Dai J, Zhao Y. Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway. Cell Res. 28(1):111-125, 2018. Liu X#, Li M#, Xia X#, Li X*, Chen Z*. Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure Nature 544 (7651):440-445, 2017 Yan L#, Wang L#, Tian Y, Xia X, Chen Z*. Structure and regulation of the chromatin remodeller ISWI. Nature 540(7633):466-469, 2016 Xu P#, Li C#, Chen Z, Jiang S, Fan S, Wang J, Dai J, Zhu P*, Chen Z* The NuA4 core complex acetylates nucleosomal histone H4 through a double recognition mechanism. Mol. Cell. 63 (6):965-75, 2016 Cao T, Sun L, Jiang Y, Huang S, Wang J, Chen Z*. Crystal structure of a nuclear actin ternary complex. PNAS.113(32): 8985-90, 2016 Xia X#, Liu X#, Li T, Fang, X, Chen Z*. Structure of chromatin remodeller Swi2/Snf2 in the resting state. Nat. Struct. Mol. Biol. 23(8):722-9, 2016