王一国 - 清华大学 - 生命科学学院

个人简介

1997.9－2001.7 曲阜师范大学生命科学学院学士 2001.9－2007.1 中科院上海生物化学与细胞生物学研究所博士 2007.8－2012.8 美国索儿克研究所博士后 2012.8－清华大学生命科学学院副教授

研究领域

糖脂代谢稳态的激素信号调控： 1. 高等生物特有新激素的发现 2. 新激素对糖脂代谢稳态的调控 3. 新激素在代谢性疾病中的作用

近期论文

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Aijun Long#, Yang Liu#, Xinlei Fang, Liangjie Jia, Zhiyuan Li, Jiang Hu, Shuang Wu, Chao Chen, Ping Huang* and Yiguo Wang*. (2023) Famsin, a novel gut-secreted hormone, contributes to metabolic adaptations to fasting via binding to its receptor OLFR796. Cell Res. 33, 273-287. (Cover article) Yi Liu#, Yuanyuan Zhang#, Tong Li, Jinbo Han and Yiguo Wang*. (2020) The tight-junction protein TJP1 regulates the feeding-modulated hepatic circadian clock. Nat Commun. 11(1), 589. Erwei Li#, Haili Shan#, Liqun Chen#, Aijun Long#, Yuanyuan Zhang#, Yang Liu, Liangjie Jia, Fangchao Wei, Jinbo Han, Tong Li, Xiaohui Liu, Haiteng Deng and Yiguo Wang*. (2019) OLFR734 mediates glucose metabolism as a receptor of Asprosin. Cell Metab. 30, 319-328. Liqun Chen#, Ke Wang#, Aijun Long, Liangjie Jia, Yuanyuan Zhang, Haiteng Deng, Yu Li, Jinbo Han and Yiguo Wang*. (2017) Fasting-induced hormonal regulation of lysosomal function. Cell Res. 27, 748-763. Jinbo Han#, Erwei Li#, Liqun Chen, Yuanyuan Zhang, Fangchao Wei, Jieyuan Liu, Haiteng Deng and Yiguo Wang*. (2015). The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Nature 524, 243-246. Yiguo Wang, Gang Li, Jason Goode, Jose C. Paz, Kunfu Ouyang, Robert Screaton, Wolfgang H. Fischer, Ju Chen, Ira Tabas and Marc Montminy*. (2012). InsP3 receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature 485, 128-132. Yiguo Wang, Hiroshi Inoue, Kim Ravnskjaer, Kristin Viste, Nina Miller, Yi Liu, Susan Hedrick, Liliana Vera, and Marc Montminy*. (2010). Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc Natl Acad Sci U S A. 107, 3087-3092. Yiguo Wang, Liliana Vera, Wolfgang H Fischer, Marc Montminy*. (2009). The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 460, 534-537. Yiguo Wang, Dan Du, Longhou Fang, Guang Yang, Chenyi Zhang, Rong Zeng, Axel Ullrich, Friedrich Lottspeich, Zhengjun Chen*. Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. The EMBO Journal. (2006) 25, 5058-5070.