江鹏 - 清华大学 - 生命科学学院

个人简介

1999-2003年安徽大学生物技术系学士 2003-2008年中国科学技术大学分子细胞生物学系博士 2008-2013年美国宾夕法尼亚大学医学院博士后 2013-2014年美国宾夕法尼亚大学医学院 Research Associate 2014-2021年清华大学生命科学学院助理教授 2021- 清华大学生命科学学院副教授 2020- 清华-北大生命科学联合中心，PI

研究领域

肿瘤和免疫代谢。实验室主要研究肿瘤和免疫细胞中代谢异常发生的调控机制，以及细胞感知微环境中代谢物质改变的分子机制和生理、病理功能

近期论文

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Cheng J#, Yan J#, Liu Y#, Shi J#, Wang H, Zhou H, Zhou Y, Zhang T, Zhao L, Meng X, Gong H, Zhang X*, Zhu H*, Jiang P*. Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment. Cell Metabolism. (2023) Jun 6;35(6):961-978. Cheng J#, Liu Y#, Yan J#, Zhao L, Zhou Y, Shen X, Chen Y, Chen Y, Meng X, Zhang X*, Jiang P*. Fumarate suppresses B-cell activation and function through direct inactivation of LYN. Nat Chem Biol. (2022) Sep;18(9):954-962. Liu Y, Chen YN, Cheng J, Yan JX, Xue CY, Pan HY, Shen XY, Zhou J, Jiang P*, Zhou YL*, Zhang XX*. Ultrasensitive HPLC-MS Quantification of S-(2-Succino) Cysteine Based on Ethanol/Acetyl Chloride Derivatization in Fumarate Accumulation Cells. Anal Chem. (2023) 2023 Jan 10. doi: 10.1021/acs.analchem.2c03573. Zhao M#, Yao P#, Mao Y#, Wu J#, Wang W, Geng C, Cheng J, Du W * and Jiang P*. Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate. Nature Metabolism. (2022) Feb 28；4(2):225-238. Mao Y, Shi D, Li G, Jiang P*. Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses. Molecular Cell. (2022) Feb 3;82(3):527-541. Wu J#, Li G#, Li D, Zhou J, Dong Z, Jiang P*. Detection of CD8+ T cell-mediated immune responses to bacterial infection in mice. STAR Protoc. (2021) Dec 13;2(4):101022. Li G#, Wu J#, Li L, Jiang P*. p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage. Proc Natl Acad Sci U S A. (2021) Jul 13;118(28) Wu J#, Li G#, Li L, Li D, Dong Z, Jiang P*. Asparagine enhances LCK signalling to potentiate CD8+ T cell-activation and anti-tumour responses. Nature Cell Biology, (2021) 23(1):75-86. Deng L, Yao P, Li L, Ji F, Zhao S, Xu C, Lan X, Jiang P*. p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival. Nature Communications, (2020) 11, 1755-18. Li L, Mao Y, Zhao L, Li L, Wu J, Zhao M, Du W, Yu L, Jiang P*. p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis. Nature. (2019) 567(7747):253-256. Li L#, Li L#, Li W, Chen T, Bin Zou, Zhao L, Wang H, Wang X, Xu L, Liu X, Wang D, Li B, Mak TW, Du W*, Yang X*, Jiang P*. TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation. Nature Communications. (2018), Nov 8; 9(1):4683. Yao P, Sun H, Xu C, Chen T, Zou B, Jiang P*, Du W*. Evidence for a direct cross-talk between malic enzyme and the pentose phosphate pathway via structural interactions. J Biol Chem. (2017) Oct 13; 292(41):17113-17120. Du W#, Jiang P#, Mancuso A, Stonestrom A, Brewer M, Minn AJ, Mak TW, Wu M* and Yang X*. TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nature Cell Biology. (2013), Aug. 15, 991-1000. Jiang P#, Du W#, Mancuso A, Wellen KE, Yang X*. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. (2013), Jan. 493: 689-693. Jiang P#, Du W#, Wang X, Mancuso A, Gao X, Wu M* and Yang X*. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nature Cell Biology. (2011) Mar.13: 310-316.