陈应华 - 清华大学 - 生命科学学院

个人简介

教育经历 1978－1982 就读于武汉大学病毒系，获理学学士学位（病毒学） 1983－1990 就读于德国慕尼黑大学，获博士学位（免疫学）工作经历 1982－1983 在武汉大学病毒系工作（助教） 1990－1991 在德国慕尼黑大学免疫学研究所工作（研究助理） 1991－1996 在奥地利因斯布鲁克大学工作（课题组长） 1996－至今在清华大学生物系（2009年改名生命学院）工作（教授）

研究领域

艾滋病病毒感染机理和预防机理；病毒抑制剂及重组表位疫苗的基础研究

近期论文

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1. Chang Zhou, Lu Lu, Suiyi Tan, Shibo Jiang*, Ying-Hua Chen*. HIV-1 gp41 ectodomain induces activation of the CD74-mediated ERK/MAPK pathway to enhance viral infection. Journal of Biological Chemistry 2011.286: 44869-77. 2. Xiaowen Yu, Lu Lu, Lifeng Cai, Pei Tong, Suiyi Tan, Peng Zou, Fanxia Meng, Ying-hua Chen*, and Shibo Jiang*. Mutations of Gln64 in the HIV-1 gp41 N-terminal heptad repeat render viruses resistant to peptide HIV fusion inhibitors targeting gp41 pocket. Journal of Virology. 2012, 86: 589-593. 3. Zhu Y, Lu L, Xu LL, Yang HW, Jiang Shibo*, Chen YH*. Identification of a gp41 Core-binding Molecule with Homologous Sequence of Human TNNI3K Like Protein as a Novel Human Immunodeficiency Viruses Type 1 Entry Inhibitor. Journal of Virology. 2010;84(18):9359-68. 4. Chen X, Lu L, Qi Z, Lu H, Wang J, Yu X, Chen YH*, Shibo Jiang*. Novel recombinant engineered gp41 N-terminal heptad-repeat trimers: potential as anti-HIV-1 therapeutics or microbicides. Journal of Biological Chemstry. 2010;285(33):25506-15. 5. Huang JH, Qi Z, Wu F, Kotula L, Jiang SB*, Chen YH*. Interaction of HIV-1 gp41 core with NPF motif in Epsin - Implication in endocytosis of HIV. Journal of Biological Chemstry 2008;283(22):14994-15002. 6. Lu L, Zhu Y, Huang JH, Chen X, Yang HW, Jiang SB*, Chen YH*. Surface exposure of the HIV-1 Env cytoplasmic tail LLP2 domain during the membrane fusion process - Interaction with gp41 fusion core. Journal of Biological Chemstry.2008;283(24):16723-16731. 7. Huang JH, Lu L, Lu H, Chen X, Jiang S, Chen YH. Identification of the HIV-1 gp41 core-binding motif in the scaffolding domain of caveolin-1. Journal of Biological Chemistry. 2007, 282: 6143–6152. 8. Huang JH, Yang HW, Liu S, Jiang S, Chen YH. The mechanism by which molecules containing the HIV-1 gp41 core-binding motif HXXNPF inhibit HIV-1 envelope glycoprotein-mediated syncytium-formation. Biochemical Journal.2007, 403: 565-571. 9. Yue Tan, Junyi Wang, Shan Su, Qian Wang , Shibo Jiang*, Lu Lu* and Chen YH*. Enhancement of endocytic uptake of HIV-1 virions into CD4-negative epithelial cells by HIV-1 gp41 via its interaction with POB1. Cellular & Molecular Immunology.(2017) 14(6):568-571 10. Tan Y, Tong P, Zhao L, Li J, Wang J*, Chen YH*. The membrane proximal region of CCR5 participates in the cellular entry of HIv-1. Front Immunology (2017), 8:478