陈晔光 - 清华大学 - 生命科学学院

个人简介

1979-1983 江西大学生物系，生物学学士 1983-1986 江西大学生物系，动物学硕士 1988-1990 美国福特汉姆大学，细胞生物学硕士 1991-1996 美国爱因斯坦医学院，细胞生物学博士 1996-2000 美国霍华德·休斯医学研究所斯隆-凯特琳癌症中心，博士后 2000-2002 美国加州大学Riverside分校，Assistant Professor 2002-至今清华大学生命科学学院，教授、博导荣誉、奖励及参加学术团体的情况现任中国细胞生物学会理事长、Cell Regeneration杂志主编以及Cell Research、Cell Discovery、Open Biology、Cancer Sciences和《中国科学:生命科学》等期刊编委

研究领域

探究TGF-β和Wnt信号调控细胞命运的分子机制和生理病理功能运用分子生物学、细胞生物学、生物信息学等多学科技术手段，结合类器官技术和小鼠模型等，研究肠、胃等成体干细胞自我更新和分化的机制，并探索相关疾病发生发展的机理

近期论文

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Zhao L, Song W, Chen YG#. 2022 Mesenchymal-epithelial interaction regulates gastrointestinal tract development in mouse embryos. Cell Reports, 40(2):111053. Kang KX, Shi QN, Wang X, Chen YG#. 2022 Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly, Journal of Cell Biology, 221(12):e202205069. Nong J, Kang K, Shi Q, Zhu X, Tao Q, Chen YG#. 2021 Phase separation of Axin organizes the β-catenin destruction complex. Journal of Cell Biology, 220(4):e202012112. Wang YL, Song WL, Wang JL, Wang T, Xiong XC, Qi Z, Fu W#, Yang XR#, Chen YG#. 2020 Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine. Journal of Experimental Medicine, 217(2):e20191130. Li Y, Liu Y, Chiang YJ, Huang F, Li Y, Li X, Ning Y, Zhang W, Deng H, Chen YG#. 2019 DNA damage activates TGF-β signaling via ATM-c-Cbl-mediated stabilization of the type II receptor TβRII. Cell Reports, 28(3):735. Qi Z, Li Y, Zhao B, Xu C, Liu Y, Wang X, Yang X, Li B, Han JD, Chen YG#. 2017 BMP restricts the self-renewal of intestinal Lgr5+ stem cells by directly suppressing their signature genes. Nature Communications, 8:13824. Zhao B, Qi Z, Li Y, Wang C, Fu W and Chen YG#. (2015) Non-muscle-myosin-II mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells via the Rac1-PAK1-Akt axis. Nature Communications, 6:7166. Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG# 2013 c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor. Molecular Cell, 49(3):499. Li Z, Fei T, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG# 2012 BMP4 signaling acts via Dual Specificity Phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell, 10:171. Gao C, Cao W, Bao W, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG# 2010 Autophagy negatively regulates Wnt signaling by promoting Dishevelled degradation. Nature Cell Biology, 12:781.