项金宝 - 吉林大学

个人简介

项金宝：男，1983年8月出生于浙江省永康市。2004年毕业于吉林大学化学学院，获理学学士学位；2004年-2008年，吉林大学化学学院学习，获有机化学博士学位，同年留校任教。2011年晋升为副教授。近年来主持和参加国家自然科学基金项目4项，国家十一五重大新药创制科技重大专项子课题2项，吉林省科技发展计划项目1项。自攻读博士学位以来，一直从事有机合成和药物化学方面的科研工作。在此期间，参与构建了以特权结构为基础的新颖嘧啶并杂环化合物研究体系。先后在Org. Lett.、J. Org. Chem.、ACS Comb. Sci.等杂志发表SCI收录论文18篇，其中影响因子3.0以上10篇（7篇为第一作者或通讯作者），申请国家发明专利3项。自2011年起担任国家自然科学基金评审专家，ACS Comb. Sci.、Bioorg. Med. Chem. Lett.、J. Heterocyclic Chem.等国际杂志审稿人。

研究领域

潜在生物活性骨架的合成方法学研究；药物合成新工艺研究；天然产物结构修饰与改造。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. T. Zhu, J. Xiang, Z. Liu, Q. Dang, X. Bai, “Synthesis of Isoxazolidine-fused Eight-Membered Heterocycles via an Intramolecular Nitrone-Alkene Cycloaddition” Synlett. 2015, 26, 238–242. 2. K. Yang, J. Xiang*, G. Bao, Q. Dang*, X. Bai, “Synthesis of Highly Substituted 4H-Pyrido[1,2?6?2a]pyrimidines via a One-Pot Three-Component Condensation Reaction” ACS Comb. Sci. 2013, 15, 519–524. (*通讯作者) 3. J. Xiang, H. Li, K. Yang, L. Yi, Y. Xu, Q. Dang, X. Bai, “Synthesis of Novel 4H-Pyrimido[1,6-a]pyrimidines Via a One-Pot Three-component Condensation” Mol. Divers. 2012, 16, 173–181. 4. H. Xie, J. Xiang, Q. Dang, X. Bai, “A Highly Stereo-controlled Intramolecular Cycloaddition Reaction of Azomethine Ylide Activated by a Pyrimidine Ring: Access to Novel Tricyclic Hexahydro-1H-pyrrolo[2',3':4,5]pyrido[2,3-d]pyrimidines” Synlett. 2012, 23, 585–588. 5. J. Xiang, C. Geng, L. Yi, Q. Dang, X. Bai, “Synthesis of highly substituted 2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-ones from 4,6-dichloro-5-formylpyrimidine, amines and aldehydes” Mol. Divers. 2011, 15, 839–847. 6. J. Xiang, X. Hu, Q. Dang, X. Bai, “Synthesis of Novel 6,7-Dihydro-5H-pyrimido[4,5-e][1,4]diazepin-8(9H)-ones” J. Heterocyclic Chem. 2011, 48, 1091–1094. 7. J. Xiang, T. Zhu, Q. Dang, X. Bai, “Stereochemistry as a Tool in Deciphering the Processes of a Tandem Iminium Cyclization and Smiles Rearrangement” J. Org. Chem. 2010, 75, 8147–8154. 8. J. Xiang, D. Wen, H. Xie, Q. Dang, X. Bai, “Synthesis of Novel 8,9-Dihydro-5H-pyrimido[4,5-e][1,4] diazepin-7(6H)-ones” ACS Comb. Sci. 2010, 12, 503–509. 9. F. Yang, L. Zheng, J. Xiang, Q. Dang, X. Bai, “Synthesis of Hexahydrobenzo[b]pyrimido[4,5-h][1,6] naphthyridines via an Intramolecular Hetero-Diels-Alder Reaction” ACS Comb. Sci. 2010, 12, 476–481. 10. J. Xiang, L. Zheng, T. Zhu, Q. Dang, X. Bai, “Synthesis of Novel Tricyclic 4-Chloro-7,8,10,11-tetrahydro-5H-benzo[e]pyrimido[4,5-b][1,4]diazepin-9(6H)-ones” J. Heterocyclic Chem. 2010, 47, 990–993. 11. J. Xiang, H. Xie, D. Wen, Q. Dang, X. Bai, “Synthesis of Pyrido[2,3-e]pyrrolo[1,2-a]pyrazine Derivatives by Tandem Iminium Cyclization and Smiles Rearrangement” J. Org. Chem. 2008, 73, 3281–3283. 12. J. Xiang, L. Zheng, H. Xie, X. Hu, Q. Dang, X. Bai, “Pyrrolo-dihydropteridines via a Cascade Reaction Consisting of Iminium Cyclization and O-N Smiles Rearrangement” Tetrahedron 2008, 64, 9101–9107. 13. J. Xiang, L. Zheng, F. Chen, Q. Dang, X. Bai, “A Cascade Reaction Consisting of Pictet-Spengler-Type Cyclization and Smiles Rearrangement: Application to the Synthesis of Novel Pyrrole-Fused Dihydropteridines” Org. Lett. 2007, 9, 765–767. 14. L. Zheng, J. Xiang, Q. Dang, S. Guo, X. Bai, “Design and Synthesis of a Tetracyclic Pyrimidine-Fused Benzodiazepine Library” ACS Comb. Sci. 2006, 8, 381–387. 15. L. Zheng, Q. Dang, S. Guo, J. Xiang, X. Bai, “Synthesis of Novel 1,6-Disubstituted-5,6-dihydropyrrolo[1,2-f] pteridines” Chem. J. Chinese Univ. 2006, 27, 1869–1872. 16. L. Zheng, J. Xiang, Q. Dang, S. Guo, X. Bai, “Novel Heterocyclic Scaffold Consisting of Indole-Fused Pteridines” ACS Comb. Sci. 2005, 7, 813–815. 17. L. Zheng, J. Xiang, X. Bai, “A One-pot Procedure for Ring Enlargement of α-Chloromethyl N-Containing Heterocycles” J. Heterocyclic Chem. 2005, 43, 321–324. 18. L. Zheng, T. Wang, Z. Wei, J. Xiang, X. Bai, “A novel intramolecular Diels–Alder cyclization involving indoloazepines” Tetrahedron Lett. 2005, 46, 3529–3532.