郑连友 - 吉林大学

个人简介

郑连友：男，1975年9月生。博士，副教授。1999年毕业于山东医科大学（现山东大学）药学院，获理学学士学位；1999年-2002年，沈阳药科大学制药工程学院学习，获药物化学硕士学位；2002年-2005年，吉林大学化学学院，获有机化学博士学位，同年留校任教。2009年9月受聘吉林大学药学院/组合化学与创新药物研究中心副教授。目前主要从事有机化学和药物化学领域的研究。曾获得国家自然科学基金委青年基金1项（项目编号：20802024）、教育部博士学科点课题1项（编号：20070183038），并参与多项省部级科研项目。已在国内外有机化学和药物化学杂志发表学术论文20余篇。

研究领域

具有潜在生物活性化合物的设计与合成；具有重要生物活性天然产物的结构改造；蛋白激酶抑制剂类小分子抗癌药物的合成。

近期论文

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[1]Zhang, Y.; Zhu, Y.; Zheng, L.; Zhuo, L. G.; Yang, F.; Dang, Q.; Yu, Z. X.*; Bai, X.*, On‐Demand Selection of the Reaction Path from Imino Diels–Alder to Ene‐Type Cyclization: Synthesis of Epiminopyrimido [4, 5‐ ] azepines. European Journal of Organic Chemistry 2014 (3), 660-669, 2014 [2]Xu, G.; Zheng, L.; Dang, Q.; Bai, X.*, Total Synthesis of 4-Azaeudistomin Y1 and Analogues by Inverse-ElectronDemand Diels–Alder Reactions of 3-Aminoindoles with 1, 3, 5-Triazines. Synthesis 45 (06), 743-752, 2013 [3]Hu, C.-m.; Zheng, L.-y.; Pei, Y.-z.; Bai, X.*, Synthesis of novel 3-aryl isoindolinone derivatives. Chemical Research in Chinese Universities 29 (3), 487-494, 2013 [4]Chen, X.; Sassano, M. F.; Zheng, L.; Setola, V.; Chen, M.; Bai, X.; Frye, S. V.; Wetsel, W. C.; Roth, B. L.; Jin, J.*, Structure–functional selectivity relationship studies of β-arrestin-biased dopamine D2 receptor agonists. Journal of medicinal chemistry 55 (16), 7141-7153, 2012 [5]He, X.-l.; Xu, X.-x.; Zheng, L.-y.; Bai, X., Merger of Ezetimibe and Statin: a Potential Dual Inhibitor. Chemical Research in Chinese Universities 27 (2), 232-236, 2011 [6]Yang, F.; Zheng, L.; Xiang, J.; Dang, Q.; Bai, X., Synthesis of Hexahydrobenzo [b] pyrimido [4, 5-h][1, 6] naphthyridines via an Intramolecular Hetero-Diels− Alder Reaction. Journal of combinatorial chemistry 2010, 12 (4), 476-481. [7]Xu, G.; Zheng, L.; Wang, S.; Dang, Q.; Bai, X., Regiospecific Syntheses of 3-Aza-α-carbolines via Inverse Electron-Demand Diels-Alder Reactions of 2-Aminoindoles with 1, 3, 5-Triazines. Synlett 2009, 2009 (19), 3206-3210. [8]Wei, Z.; Zheng, L.; Dang, Q.; Bai, X., An efficient method to prepare 4‐aminoquinazolines: Potential application to conformation‐ estricted bleomycin analogs. Journal of Heterocyclic Chemistry 2009, 46 (6), 1425-1429. [9]Zheng, L.; Yang, F.; Dang, Q.; Bai, X., A cascade reaction with iminium Ion isomerization as the Key step leading to tetrahydropyrimido [4, 5-d] pyrimidines. Organic letters 2008, 10 (5), 889-892. [10]Xiang, J.; Zheng, L.; Xie, H.; Hu, X.; Dang, Q.; Bai, X., Pyrrolo-dihydropteridines via a cascade reaction consisting of iminium cyclization and O–N Smiles rearrangement. Tetrahedron 2008, 64 (38), 9101-9107. [11]Zheng, L. Y.; Bai, X., Grignard addition to quinoxalinium salt: synthesis of 1, 2-dihydroquinoxaline and 1, 2, 3, 4-tetrahydroquinoxaline derivatives. Chinese Chemical Letters 2006, 17 (2), 165. [12]Zheng, L.; Xiang, J.; Dang, Q.; Guo, S.; Bai, X., Design and synthesis of a tetracyclic pyrimidine-fused benzodiazepine library. Journal of combinatorial chemistry 2006, 8 (3), 381-387. [13]Zheng, L.; Xiang, J.; Dang, Q.; Guo, S.; Bai, X., Novel heterocyclic scaffold consisting of indole-fused pteridines. Journal of combinatorial chemistry 2005, 7 (6), 13-815. [14]Zheng, L.; Wang, T.; Wei, Z.; Xiang, J.; Bai, X., A novel intramolecular Diels–Alder cyclization involving indoloazepines. Tetrahedron letters 2005, 46 (20), 3529-3532.