个人简介
1964年10月23日出生,教授,博士生导师,院学术委员会成员,微生物与生化药学专业学科带头人,基因工程教研室主任。2003年于吉林大学生命科学院取得博士学位,被评为优秀博士毕业生,2004年破格晋升为教授,2005年被评为博士生导师;2006年作为访问学者和博士后出访美国肯塔基大学药学院。自2007年以来先后入选吉林省拔尖创新人才,吉林省有突出贡献的专业技术人才,省级优秀博士论文指导教师,国家自然科学基金、国家优秀博士论文,教育部科技进步奖等评审专家,2013年获我校白求恩医学部医学教育贡献奖。
研究领域
人工酶与基因工程药物、纳米材料在生物医药领域的应用。
近期论文
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1.Characterization and structural analysis of human selenium-dependent glutathione peroxidase 4 mutant expressed in Escherichia coli. Free Radical Biology and Medicine, 2014, 71(4), 332–338. 2.Heterologous expression and characterization of human cellular glutathione peroxidase mutants, IUBMB Life, 2014, 66(3), 212-219. 3.Can recombinant human glutathione peroxidase 1 with high activity be efficiently produced in Escherichia coli? ANTIOXIDANTS AND REDOX SIGNALING, 2014, 20(9), 1524-1530. 4.A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy, BIOMATERIALS, 2014, 35(7), 2383-2390. 5.Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidase, IUBMB Life, 2013, 65(11), 95-956. 6.Characterization of catalytic activity and structure of selenocysteine-containing hGSTZ1c-1c based on site-directed mutagenesis and computational analysis, IUBMB Life, 2013, 65(2)163-170. 7.Characterization of selenium-containing glutathione transferase zeta1-1 with high GPX activity prepared in eukaryotic cells. Journal of molecular recognition, 2013, 26(1), 38-45. 8.Expression of selenocysteine containing glutathione S-transferase in eukaryote, Protein expression and purification, 2012, 84(1), 59-63 9.Deciphering an underlying mechanism of differential cellular effects of nanoparticles: an example of bach-1 dependent induction of HO-1 expression by gold nanorod. Biointerphases, 212, 7(1-4), 10. 10.Antioxidant effect of selenium-containing glutathione S-transferase in rat cardiomyocytes,CHEM. RES. CHINESE UNIVERSITIES 2012, 283), 454-458. 11.Direct evidence for catalase and peroxidase activities of ferritin-platinum nanoparticles.Biomaterals, 2011, 32(6), 1611-1618. 12.A new human catalytic antibody Se-scFv-2D8 and its selenium-containing single domains with high GPX activity, Journal of molecular recognation, 2010, 23(4):352-359. 13.Thromboxane receptor alpha mediates tumor growth and angiogenesis via induction of vascular endothelial growth factor expression in human lung cancer cells,Lung Cancer, 2010, 69(1): 26-32.