杜玮 - 四川大学 - 华西药学院

个人简介

2002-2006四川大学华西药学院（本科） 2006-2009四川大学华西药学院药物化学专业（硕士）师从陈应春教授 2009-2014香港大学理学院化学系（博士）师从杨丹教授 2015-0217四川大学华西药学院，讲师 2017-至今四川大学华西药学院，副教授

研究领域

一直着力于金属、手性小分子等多种催化体系以及协同催化体系，以发展新型的不对称反应，构建复杂手性类药性骨架，目前已建立了十余种多官能团、多手性中心化合物的合成新方法，建立数百个新型化合物库为进一步发现和设计新型生理活性手性化合物奠定坚实基础。主要包括以下两个研究方向 1.设计手性硫醇类催化剂，以其作为新型的Lewis碱应用于多类不对称催化反应中，合成多取代的手性产物。 2.以过渡金属钯活化含酸性氢的烯丙醇衍生物，通过原位形成的含π-烯丙基钯配合物的偶极子发展多类不对称环化反应，构建复杂的手性环状骨架。

近期论文

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Zhen-Hong Yang, Peng Chen, Zhi-Chao Chen, Zhi Chen,Wei Du,* and Ying-Chun Chen,* “A double deprotonation strategy for cascade annulations of palladium-trimethylenemethanes and Morita-Baylis-Hillman carbonates to construct bicyclo[3.1.0]hexane frameworks”,Angew. Chem. Int. Ed.2021, DOI: 10.1002/anie.202102842 Ben-Xian Xiao, Bo Jiang,Ru-Jie Yan, Jian-Xiang Zhu, Ke Xie, Xin-Yue Gao, Qin Ouyang,*Wei Du,* and Ying-Chun Chen,* “Palladium complex as asymmetricπ-Lewis base catalyst for activating 1,3-dienes”,J. Am. Chem. Soc.2021, 143,12, 4809–4816 Bao-Xin Liu, Ru-Jie Yan, Xiao-Xun Li,Wei Du,* and Ying-Chun Chen,* “Asymmetric [3+2] annulations of thioaurone and aurone derivatives for the construction ofspiroheterocycles”,Asian J. Org. Chem.2021,10, 784. Xue Song, Ru-Jie Yan,Wei Du,* and Ying-Chun Chen,* “Asymmetric dearomative cascade multiple functionalizations of activated N-alkylpyridinium and N-alkylquinolinium salts”,Org. Lett.2020,22, 7617. Ying Jiang, Yang Yang,Qing He,Wei Du,* and Ying-Chun Chen,* “Asymmetric intramolecular Rauhut-Currier reaction and its desymmetric version via double thiol/phase-transfer catalysis”,J. Org. Chem.2020,85, 10760. Guang-Yao Ran, Chen Chen, Xing-Xing Yang,Zhi Zhao,Wei Du,* and Ying-Chun Chen,* “Cu(I)-catalyzed asymmetricα-allenylation of activated ketimines with 3-butynoates”,Org. Lett.2020,22, 4732. Bo Jiang,Wei Du,*and Ying-Chun Chen,* “Modified cinchona alkaloid‐catalysed enantioselective [4 + 4] annulations of cyclobutenones and 1-azadienes”,Chem. Commun.2020,56,7257. Zhi-Chao Chen, Zhi Chen,Wei Du,* and Ying-Chun Chen,* “Transformations of modified Morita–Baylis–Hillman adducts from isatins catalyzed by Lewis bases”,Chem. Rec.2020,20, 541. Zhi Zhou, Qing He, Ying Jiang, Qin Ouyang,Wei Du,* and Ying-Chun Chen,* “Double thiol-chiral Brønsted base catalysis: Asymmetric cross Rauhut-Currier reaction and sequential [4 + 2] annulation for assembly of different activated olefins”,Org. Lett.2019,21, 7184. Zhi-Chao Chen, Zhi Chen, Zhen-Hong Yang,Li Guo,Wei Du,* and Ying-Chun Chen,* “Cooperativetertiary amine/chiral iridium complex catalyzed asymmetric [4+3] and [3+3] annulation reactions”,Angew. Chem. Int. Ed.2019,58, 15021. Guang-Yao Ran,Xing-Xing Yang,Jing-Fei Yue,Wei Du,* and Ying-Chun Chen,* “Asymmetric allylic alkylations with deconjugated carbonyl compounds: Direct vinylogous umpolung strategy”,Angew. Chem. Int. Ed.2019,58, 9210. Xiao-Long He, Hui-Ru Zhao,Xue Song,Bo Jiang,Wei Du,*and Ying-Chun Chen,* “Asymmetric Barton-Zard reaction to access 3-pyrrole-containing axially chiral skeletons”,ACSCatal.2019,9,4374. Peng Chen,Zhi-Chao Chen, Yue Li,Qin Ouyang,Wei Du,* and Ying-Chun Chen,* “Auto-tandem cooperative catalysis using phosphine/palladium: Reactionof Morita-Baylis-Hillman carbonates and allylic alcohols”,Angew. Chem. Int. Ed.2019,58, 4036. Qian-Qian Yang, Xiang Yin, Xiao-Long He,Wei Du,* and Ying-Chun Chen,* “Asymmetric formal [5 + 3] cycloadditions with unmodified Morita-Baylis-Hillman alcohols via double activation catalysis”,ACS Catal.2019,9, 1258. Ben-Xian Xiao, Xin-Yue Gao,Wei Du,* and Ying-Chun Chen,* “Asymmetric reactions involving Lewis Base catalyst-tethered dearomatizativeintermediates”,Chem. Eur. J.2019,25, 1607. Jing-Fei Yue, Guang-Yao Ran, Xing-Xing Yang,Wei Du,* and Ying-Chun Chen,* “Asymmetric Diels-Alder cycloadditions of benzofulvene-based 2,4-dienals via trienamine activation”,Org. Chem. Front.2018,5, 2676. Wei Xiao, Zhi Zhou, Qian-Qian Yang, Wei Du,* and Ying-Chun Chen,* “Organocatalyticasymmetric four-component [5+1+1+1] cycloadditions via a quintuple cascade process”,Adv. Synth. Catal.2018,360, 3526. Yuanchun Zhou, Zhi Zhou,Wei Du,* Yingchun Chen,* “Asymmetric inverse-electron-demandDiels-Alderreaction of 2-pyrone and 2,5-dienones via HOMO-activation”,Acta Chim. Sinica2018,76, 382. Chuan-Qi Duan, Xiao-Long He,Wei Du,* and Ying-Chun Chen,* “Asymmetric [4 + 2] cycloadditions with 3-furfural derivatives anda-cyano-a,b-unsaturated ketones”,Org. Chem. Front.2018,5, 2057. Minglin Shi, Gu Zhan,Wei Du,* Yingchun Chen,* “Direct asymmetric aza-vinylogous Mannich reaction of nitrones from isatins and ketimines”,Acta Chim. Sinica2017,75, 998. Gu Zhan,Ming-Lin Shi, Wei-Jia Lin, Qin Ouyang,Wei Du,* and Ying-Chun Chen,* “Direct asymmetric aza-vinylogous-type Michael additions of nitrones from isatins to nitroalkenes”,Chem. Eur. J.2017,23, 6286. Gu Zhan#,Wei Du#, Ying-Chun Chen,* “Switchable divergent asymmetric synthesis via organocatalysis”,Chem. Soc. Rev.2017,46, 1675. Wei-Jia Lin,Gu Zhan,Ming-Lin Shi,Wei Du,* and Ying-Chun Chen,* “[3+3] formal cycloadditions of nitrones from isatins and azaoxyallyl cations for construction of spirooxindoles”,Chin. J. Chem.2017,35, 857. Wei Du,Qiangshuai Gu, Yang Li, Zhenyang Lin, Dan Yang,*“Enantioselective palladium-catalyzed oxidative cascade cyclization of aliphatic alkenyl amides”, Org. Lett.2017,19, 316.