刘聪 - 中国科学院上海有机化学研究所 -

个人简介

EDUCATION/TRAINING 1998-2002 B.S. Jilin University, Jilin, China 2002 Research assistant, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China 2002-2008 Ph.D. Peking University, Beijing, China 2003-2004 Graduate student, Beijing Nuclear Magnetic Resonance Center, Peking University, China 2007 Visiting scholar, DESY (German Electron Synchrotron), Hamburg, Germany PROFESSIONAL EXPERIENCE 2008-2013 Postdoctoral Fellow, UCLA, HHMI. USA 2013-present Principal investigator, IRCBC, CAS. China ACADEMIC HONORS AND AWARDS 2012 IUCr international travel grant, International Workshop on New Developments of Methods and Software for Protein Crystallography, Xian, China. 2012 ADDF Young Investigator Scholarship, the 6th Drug Discovery for Neurodegeneration Conference, New York City, USA. 2007 Best Presentation Award, the 6th “TICPS” International Conference of Protein Science, Shanghai, China.

研究领域

1) Structural basis of pathological amyloid proteins aggregation including α-syn, Tau, FUS and hnRNPA1 which are key players in different neurodegenerative diseases (AD,PD and ALS); 2) Method development for structural characterization of amyloids in vitro and in vivo (e.g. electron diffraction, in-cell NMR, IMMS); 3) Molecular mechanism underlying the interplay between chaperones and amyloids; 4) Structure-based design of inhibitor against pathological amyloid aggregation; 5) Structural studies of liquid-liquid phase separation of different proteins involved in important biological process and pathology; 6) Design of amyloid biomaterials with applicable functions.

近期论文

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α-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1/p62-mediated selective autophagy Xu Q.H.¶, Wang H.L.¶, Yang R.N., Tao Y.Q., Wang Z.Y., Zhang S.N., Sun B., Li D., Lu B.X.*, Liu C.* Cell Res., 2024. Inhibitor Development for α-Synuclein Fibril's Disordered Region to Alleviate Parkinson's Disease Pathology Zhang S.Q.¶, Xiang H.J.¶, Tao Y.Q., Li J., Zeng S.Y., Xu Q.H., Xiao H.N., Lv S.R., Song C.W., Cheng Y., Martin L., Zhu Z.Y., Zhang S.N., Sun B., Li D., Xiang S.Q.*, Tan L.*, Liu C.* J Am Chem Soc., 2024. RPA transforms RNase H1 to a bidirectional exoribonuclease for processive RNA-DNA hybrid cleavage Li Y.N.¶, Liu C.¶, Jia X.S., Bi L.L., Ren Z.Y., Zhao Y.L., Zhang X., Guo L.J., Bao Y.L., Liu C., Li W.*, Sun B.* Nat Commun., 2024. Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency Wang P.P.¶, Shao Y.P., Murad A.N., Zhang J., Yang H.J., Yang Y.T., Kim K., Li S.,Liu C., Cai H.B., Le W.D.* Mol Neurodegener., 2024. Binding adaptability of chemical ligands to polymorphic α-synuclein amyloid fibrils Liu K.E.¶, Tao Y.Q.¶, Zhao Q.Y., Xia W.C., Li X., Zhang S.Q., Yao Y.X., Xiang H.J., Han C., Tan L., Sun B., Li D., Li A., Liu C.* Proc Natl Acad Sci U S A., 2024. Fecal microbiota from patients with Parkinson's disease intensifies inflammation and neurodegeneration in A53T mice Yang H.J.¶, Shao Y.P., Hu Y.Y., Qian J., Wang P.P., Tian L.L., Ni Y., Li S.,Murad Al-Nusaif., Liu C., Le W.D.* CNS Neurosci Ther., 2024. Ultrasensitive detection of aggregated α-synuclein using quiescent seed amplification assay for the diagnosis of Parkinson's disease Mao H.X.¶, Kuang Y.Y.¶, Feng D.¶, Chen X.¶, Lu L., Xia W.C., Gan T.T., Huang W.M.,Guo W.Y., Yi H.C., Yang Y.R., Wu Z.H., Dai W., Sun H., Wu J.Y., Zhang R., Zhang S.Q.,Lin X.L., Yong Y.X., Yang X.L., Li H.Y., Wu W.J., Huang X.Y., Bian Z.X., Wong.H.L.X.,Wang X.L., Michael P., Ren Y., Liu C., Zou W.Q., Chen S.D., Xu P.Y.* Transl Neurodegener., 2024. VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates Wang C.C.¶, Zhang K., Cai B., Jillian E.H., Kathryn E.C., Hu J.J., Zhao C.Y., Tian Z.Q., Hu X., Daniel Hall., Qiang J.L., Hou S.Q., Liu Z.Y., Gu J.G., Zhang Y.Y., Kim B.S., Jacqueline B., Fang Y.S., Liu C., Axel T.B., Li Dan.*, Diao J.J.* Nat Cell Biol., 2024. Phase-separated ParB enforces diverse DNA compaction modes and stabilizes the parS-centered partition complex Zhao Y.L.¶, Guo L.J.¶, Hu J.J.¶, Ren Z.Y., Li Y.N., Hu M., Zhang X., Bi L.L., Li D.,Ma H.H., Liu C.*, Sun Bo.* Nucleic Acids Res., 2024. Hsp90α forms condensate engaging client proteins with RG motif repeats Hu J.J.*¶, Dong H., Li Y.C., Gu J.G., Yang L., Si C.F., Zhang Y.Y., Li T.T., Li D.*, Liu C.* Chem Sci., 2024. Lysophosphatidylcholine binds α-synuclein and prevents its pathological aggregation Zhao C.Y.¶, Tu J.¶, Wang C.C.¶, Liu W.B., Gu J.G., Yin Y.D., Zhang S.N., Li D., Diao J.J.*, Zhu Z.J.*, Liu C.* Natl Sci Rev., 2024. Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein Mao X.¶, Gu H.¶, Kim D.¶, Kimura Y., Wang N., Xu E., Kumbhar R., Ming X., Wang H., Chen C., Zhang S., Jia C., Liu Y., Bian H., Karuppagounder SS., Akkentli F., Chen Q., Jia L., Hwang H., Lee SH., Ke X., Chang M., Li A., Yang J., Rastegar C., Sriparna M., Ge P., Brahmachari S., Kim S., Zhang S., Shimoda Y., Saar M., Liu H., Kweon SH., Ying M., Workman CJ., Vignali DAA., Muller UC., Liu C., Ko HS.*, Dawson VL.*, Dawson TM.* Nat Commun., 2024. (¶co-first author, *corresponding author) A Tau PET tracer PBB3 binds to TMEM106B amyloid fibril in brain Zhao Q.Y.¶, Fan Y.¶, Zhao W.B., Ni Y., Tao Y.Q., Bian J., Xia W.C., Yu W.B., Fan Z.,Liu C., Sun B., Le W.D., Li W.S., Wang J.*, Li D.* Cell Discov., 2024. A phase-separated protein hub modulates resistance to Fusarium head blight in wheat He Y.¶, Yang X.J.¶, Xia X.B.¶, Wang Y.H., Dong Y.F., Wu L., Jiang P., Zhang X., Jiang C., Ma H.X., Ma W.J., Liu C., Ryan W., Matthew R.T., Zhang Z.G., Li G.* Cell Host Microbe., 2024. Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures Hu J.J.¶, Xia W.C.¶, Zeng S.Y.¶, Lim Y.J.¶, Tao Y.Q., Sun Y.P., Zhao L., Wang H.S.,Le W.D., Li D., Zhang S.N., Liu C.*, Li Y.M.* Nat Commun., 2024. Halogen doped graphene quantum dots modulate TDP-43 phase separation and aggregation in the nucleus Zhang H.¶, Guo H.Z., Li D.N., Zhang Y.L., Zhang S.Q., Kang W.Y., Liu C., Le W.D., Wang L.*, Li D.*, Dai B.* Nat Commun., 2024. N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine Wang C.¶, Zhao C.¶, Hu X., Qiang J., Liu Z., Gu J., Zhang S., Li D., Zhang Y., Burré J., Diao J.*, Liu C.* bioRxiv., 2024. Machine learning predictor PSPire screens for phase-separating proteins lacking intrinsically disordered regions Hou S.¶, Hu J.J.¶, Yu Z.W., Li D, Liu C.*, Zhang Y.* Nat Commun., 2024. Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies Zhao W.B.¶, Liu K.E.¶, Fan Y.¶, Zhao Q.Y., Tao Y.Q., Zhang M.W., Gan L.H., Yu W.B., Sun B., Li D., Liu C.*, Wang J.* Cell Discov., 2024. Phosphorylation-Regulated Dynamic Phase Separation of HIP-55 Protects Against Heart Failure Jiang Y.Q.¶, Gu J.G.¶, Niu X.D.¶, Hu J.J., Zhang Y.Z., Li D., Tang Y.D., Liu C.*, Li Z.J.* Circulation., 2024. Advanced Techniques for Detecting Protein Misfolding and Aggregation in Cellular Environments Bai Y.L.¶, Zhang S.N.¶, Dong H.¶, Liu Y.,Liu C.*, Zhang X.* Chem Rev., 2023. Molecular rules governing the structural polymorphism of amyloid fibrils in neurodegenerative diseases Li D.*, Liu C.* Structure., 2023. Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering Lai Y.¶, Zhao C.Y.¶, Tian Z.Q.¶, Wang C.C.¶, Fan J.Q.¶, Hu X., Tu J., Li T.H.,Leitz Jeremy., Pfuetzne R.A., Liu Z.T., Zhang S.N., Su Z.M., Burré J., Li D.,Südhof Thomas.C., Zhu Z.J., Liu C.*, Brunger Axel.T.*, Diao J.J.* Proc Natl Acad Sci U S A., 2023. Creating an Amyloid 'Kaleidoscope' Using Short Iodinated Peptides Li D.N.¶, Ma Y.Y.¶, Xia W.C., Tao Y.Q., Zhang Y.L., Zhang H., Li D., Dai B.*, Liu C.*Angew Chem Int Ed Engl., 2023. Engineering of antimicrobial peptide fibrils with feedback degradation of bacterial-secreted enzymes Wang F.H.¶, Xia W.C.¶, Zhang M.M., Wu R.R., Song X.L., Hao Y., Feng Y.H., Zhang L.W., Li D., Kang W.Y., Liu C.*, Liu L.* Chem Sci., 2023. Rational design of functional amyloid fibrillar assemblies Wang X.Y.¶, Zhang S.N.¶, Zhang J.C., Wang Y.M., Jiang X.Y., Tao Y.Q., Li D., Zhong C.*, Liu C.*Chem Soc Rev., 2023. Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies Xiang J.¶, Tao Y.Q.¶, Xia Y.Y.¶, Luo S.L., Zhao Q.Y., Li B.W., Zhang X.Q., Sun Y.P., Xia W.C., Zhang M.M., Kang S.S., Ahn E.H., Liu X., Xie F., Guan Y.H., Yang J.J., Bu L,H., Wu S.X., Wang X.C., Cao X.B., Liu C., Zhang Z.T.*, Li D.*, Ye K.Q.* Cell., 2023. Structural mechanism for specific binding of chemical compounds to amyloid fibrils Tao Y.Q.¶, Xia W.C.¶, Zhao Q.Y.¶, Xiang H.J., Han C., Zhang S.Q., Gu W., Tang W.J, Li Y., Tan L., Li D.*, Liu C.*Nat Chem Biol., 2023. β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice Zhao Y.N.¶, Zheng Q.Y., Hong Y.J., Gao Y., Hu J.J., Lang M.J., Zhang H.F., Zhou Y., Luo H., Zhang X., Sun H., Yan X.X., Huang T., Wang Y.J., Xu H., Liu C., Wang X.*Nat Neurosci., 2023. Protein amyloid aggregate: Structure and function Xu Q.H.¶, Ma Y.Y.¶, Sun Y.P.¶, Li D., Zhang X., Liu C.* Aggregate., 2023. Modular characterization of SARS-CoV-2 nucleocapsid protein domain functions in nucleocapsid-like assembly Wang Y.¶, Ling X.B.¶, Zhang C., Zou J., Luo B.N., Luo Y.B., Jia X.Y., Jia G.W., Zhang M.H., Hu J.C., Liu T., Wang Y.F.Y., Lu K.F., Li D., Ma J.B.*, Liu C.*, Su Z.M.*Mol Biomed., 2023. Graphene Quantum Dots Modulate Stress Granule Assembly and Prevent Abnormal Phase Transition of Fused in Sarcoma Protein Zhang H.¶, Gu J.G., Zhang Y.L., Guo H.Z., Zhang S.N., Song J., Liu C., Wang L.*, Li D.*, Dai B.*ACS Nano., 2023. Emerging roles of O-glycosylation in regulating protein aggregation, phase separation, and functions Li X.¶, Lv P.¶, Du Y.F.¶, Xing C.*, Liu C.*Curr Opin Chem Biol., 2023. Conformational Dynamics of an α-Synuclein Fibril upon Receptor Binding Revealed by Insensitive Nuclei Enhanced by Polarization Transfer-Based Solid-State Nuclear Magnetic Resonance and Cryo-Electron Microscopy Zhang S.N.¶, Li J.¶, Xu Q.H.¶, Xia W.C., Tao Y.Q., Shi C.W., Li D., Xiang S.Q.*, Liu C.*J Am Chem Soc., 2023. Cannabidivarin alleviates α-synuclein aggregation via DAF-16 in Caenorhabditis elegans Wang F.R.¶, Jin T.¶, Li H.Y.¶, Long H.F., Liu Y., Jin S., Lu Y.Y., Peng Y.H., Liu C., Zhao L.H.*, Wang X.H.* FASEB J., 2023. Intrastriatal injection of Parkinson's disease intestine and vagus lysates initiates α-synucleinopathy in rat brain Yang Z.F.¶, Wang Y.¶, Wei M., Li S., Jia C.C., Cheng C., Nusaif M., Zhang J., Liu C., Le W.D.*Cell Death Dis., 2023. Targeting amyloid proteins for clinical diagnosis of neurodegenerative diseases Zhang S.Q.¶, Dong H.¶, Bian J.¶, Li D., Liu C.* Fundamental Research., 2022. Conformational change of α-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson’s disease Fan Y.¶, Sun Y.P.¶, Yu W.B., Tao Y.Q., Xia W.C., Liu Y.Q., Zhao Y.Q., Tang Y.L., Sun Y.M., Liu F.T., Cao Q., Wu J.J., Liu C., Wang J.*, Li D.*Structure., 2022. Subtle change of fibrillation condition leads to substantial alteration of recombinant Tau fibril structure Li X.¶, Zhang S.Q.¶, Liu Z.T.¶, Tao Y.Q., Xia W.C., Sun Y.P., Liu C., Le W.D., Sun B., Li D.*iScience., 2022. Activating NO-sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury He H.¶, Yang W.¶, Su N.¶, Zhang C.K., Dai J.N., Han F., Singhai M., Bai W.J., Zhu X.L., Zhu J., Liu Z., Xia W.C., Liu X.T., Zhang C.H., Jiang K., Huang W.H., Chen D., Wang Z.Y., He X.Y., Kirchhoff F., Li Z.Y., Liu C., Huan J.N., Wang X.H., Wei W., Wang J., Augustin H.G., Hu J.H.*J Exp Med., 2023. Global profiling of arginine dimethylation in regulating protein phase separation by a steric effect-based chemical-enrichment method Wang Q.¶, Li Z.X.¶, Zhang S.Q.¶, Li Y.C., Wang Y., Fang Z., Ma Y.N., Liu Z., Li D., Liu C.*, Ye M.L.*Proc. Natl. Acad. Sci. U S A., 2022. A High-Throughput Method to Profile Protein Liquid-Liquid Phase Separation Li Y.C., Gu J.G., Liu C., Li D.*Methods in Molecular Biology., 2022 Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia Long H.F.¶, Zhang S.N.¶, Zeng S.Y., Tong Y.L., Liu J., Liu C.*, Li D.*Cell Rep., 2022. Non-ergodicity of a globular protein extending beyond its functional timescale Li J.¶, Xie J.F., Godec A., Weninger K.R., Liu C., Smith J.C., Hong L.*Chem Sci., 2022. Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition Lu S.¶, Hu J.J., Arogundade O.A., Goginashvili A., Vazquez-Sanchez S., Diedrich J.K., Gu J.G., Blum J., Oung S., Ye Q.Z., Yu H.Y., Ravits J., Liu C., Yates J.R., Cleveland D.W.*Nat Cell Biol. 2022. Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology Zhang S.N.¶, Zhu Y.¶, Lu J.X.¶, Liu Z.Y., Lobato A.G., Zeng W., Liu J.Q., Zeng S.Y., Liu C., Liu J., He Z.H., Zhai R.G.*, Li D.*Elife., 2022. Bloom Syndrome Helicase Compresses Single‐Stranded DNA into Phase‐Separated Condensates Teng W.¶, Hu J.J.¶, Li Y.N., Bi L.L., Guo X.S., Zhang X., Li D., Hou X.M., Modesti M.,Xi X.G., Liu C.*, Sun B.*Angew Chem Int Ed Engl., 2022. Stochastically multimerized ParB orchestrates DNA assembly as unveiled by single-molecule analysis Guo J.L.¶, Zhao Y.L.¶, Zhang Q., Feng Y., Zhang X., Wang T., Liu C., Ma H.H., Sun B.*Nucleic Acids Res., 2022. Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology Tao Y.Q.¶, Sun Y.P.¶, Lv S.R., Xia W.C., Zhao K., Xu Q.H., Zhao Q.Y., He L., Wang Y., Liu C.*, Li D.*Nat Commun., 2022. Hyperosmotic-stress-induced liquid-liquid phase separation of ALS-related proteins in the nucleus Gao C.¶, Gu J.G., Zhang H., Jiang K., Tang L.L., Liu R., Zhang L., Zhang P.F., Liu C.*, Dai B.*, Song H.*Cell Reports., 2022. Structural insights of Fe 3+ induced α-synuclein fibrillation in Parkinson's disease Zhao Q.Y.¶, Tao Y.Q.¶, Zhao K., Ma Y.Y., Xu Q.H., Liu C., Zhang S.N., Li D.*J Mol Biol., 2022. Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion Wang L.Q.¶, Ma Y.Y.¶, Yuan H.Y.¶, Zhao K., Zhang M.Y., Wang Q., Huang X., Dai B., Chen J., Li D., Zhang D.L., Wang Z.Z., Zou L.Y., Yin P., Liu C.*, Liang Y.*Nat. Commun., 2022. Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation Li Y.C.¶, Gu J.G., Wang C., Hu J.J., Zhang S.Q., Liu C., Zhang S.N., Fang Y.S., Li D.*iScience., 2022. Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases Li D.*, Liu C.*Nat Rev Neurosci., 2022. Biochemical and biophysical characterization of pathological aggregation of amyloid proteins Long H.F., Zeng S.Y., Sun Y.P., Liu C.*Biophysics Reports., 2022. Identifying Heterozipper β-Sheet in Twisted Amyloid Aggregation Song Y.X., Dai B., Wang Y., Wang Y., Liu C., Gourdon P., Liu L.*, Wang K.T.*, Dong M.D.*Nano Lett., 2022. Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis Zhu S.B.¶, Gu J.G.¶, Yao J.J., Li Y.C., Zhang Z.T., Xia W.C., Wang Z., Gui X.R., Li L.T., Li D., Zhang H.*, Liu C.*Developmental Cell., 2022.