个人简介

Ph.D., 1990 University of British Columbia B. Sc., 1985 University of British Columbia

研究领域

Physical Chemistry

Our group is interested in the application of nanotechnology to biomedicine. These applications include nanotoxicology, multiple biomolecular binding, membrane dynamics, pain transduction, and degenerative retinal disease. We utilize a wide variety of biophysical and spectroscopic techniques in our research, including: fluorescence correlation and cross-correlation spectroscopy (FCS/FCCS), confocal microscopy, atomic force microscopy (AFM), dynamic light scattering (DLS), and transmission electron microscopy/scanning electron microscopy (TEM/SEM).

近期论文

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"Designing a Better Theranostic Nanocarrier for Cancer Applications." T. Nguyen, A. Tekrony, K. Yaehne, D. Cramb. Nanomedicine. (2014) "Testing nanoparticles for angiogenesis-related disease: Charting the fastest route to the clinic." C. Sarsons, A. Tekrony, K. Yaehne, S. Childs, K. Rinker, D. Cramb. Journal of Biomedical Nanotechnology. 10: 1641-1676 (2014) “Nanoparticle accumulation in angiogenic tissues: Towards predictable pharmacokinetics."A. Tekrony, K. Yaehne, A. Clancy, Y. Gregoriou, J. Walker, T. Nguyen, A. Doiron, K. Rinker, S. Jiang, S. Childs, D. Cramb*, Small. 9: 3118-3127 (2013). “Three-Color Fluorescence Cross-Correlation Spectroscopy for Analyzing Complex Nanoparticle Mixtures”, M.L. Blades, E. Grekova, H. Wobma, K. Chun, W.C.W. Chan, and D.T. Cramb Anal. Chem. 84: 9623-9631 (2012). “Nonblinking Plasmonic Quantum Dot Assemblies for Multiplex Biological Detection”, F.Song, P.S. Tang, H.F. Durst, D.T. Cramb, W.C. Chan. Angewandte Chemie. 51: 8773-8777 (2012). “The development of direct multicolour fluorescence cross-correlation spectroscopy: Towards a new tool for tracking complex biomolecular events in real-time”, H.M. Wobma, M.L. Blades, E. Grekova, D.L. McGuire, K. Chen, W.C.W. Chan, and D.T. Cramb Phys. Chem. Chem. Phys. 14: 3290-3294 (2012). Inside Cover Article. “Photobleaching kinetics of verteporfin and lemuteporfin in cells and optically trapped multilamellar vesicles using two-photon excitation”, A.D. Tekrony, N.M. Kelly, B.A. Fage, and D.T. Cramb Photochem. Photobiol. 87: 853-861 (2011). “Measuring properties of nanoparticles in embryonic blood vessels: Towards physicochemical basis for nanotoxicity”, A. A. Clancy, Y. Gregoriou, K. Yaehne, D.T. Cramb*, Chem. Phys. Lett. 488: 99-111 (2010). “Effects of Various Small-Molecule Anesthetics on Vesicle Fusion: A Study Using Two-Photon Fluorescence Cross-Correlation Spectroscopy ”, T. T. Nguyen, J.L. Swift, M. Burger, D.T. Cramb*, J. Phys. Chem. B 113 (30): 10357-10366 (2009). “Nanoparticles as fluorescence labels: Is size all that matters? ”, J.L. Swift, D. T. Cramb*, Biophysical Journal 95 (2): 865-876 (2008). “Fluorescence correlation spectroscopy for diffusion of mobile quantum dots in dilute solutions’’, R.F. Heuff, D.T. Cramb, M. Marrocco*, Chem. Phys. Lett., 454: 257-261 (2008). “Mechanical Gas Capture and Release in a Network Solid via Multiple Single Crystalline Transformations”, Brett D.Chandler, Gary D. Enright, Konstantin A. Udachin, Shane Pawsey, John A. Ripmeester, David T. Cramb* and George K. H. Shimizu*, Nature Materials, 7: 229-235 (2008). Featured on websites of the Materials Research Society, CBC, National Post, Popular Mechanics among several. “Quantitative in vitro demonstration of two-photon photodynamic therapy using Photofrin® and Visudyne®”, Mamta Khurana, Hazel A. Collins, Aliaksandr Karotki, Harry L. Anderson, David T. Cramb, Brian C. Wilson*, Photochem. Photobiol., 83: 1441-1448 (2007). “Saturation of two-photon excitation provides insight into the effects of a quantum dot blinking suppressant: A fluorescence correlation spectroscopy study”, R. Heuff, M. Marrocco, D.T. Cramb*, J. Phys. Chem. C, 111: 18942-18949 (2007). “A Series of Luminescent Lanthanide-Alkali Metal-Organic Frameworks Exhibiting Permanent Microporosity”, Brett D. Chandler, Joanne O. Yu, David T. Cramb,* George K.H. Shimizu*, Chemistry of Materials, 19: 4467-4473 (2007). “Quenching of gramicidin D in model membranes by halothane”, A. Carnini, T. T. Nguyen, D.T. Cramb*, Can. J. Chem. 85: 513-519 (2007). “Two-photon excitation fluorescence cross-correlation assay for ligand-receptor binding: Cell membrane nanopatches containing the human mu-opioid receptor”, J.L. Swift, M. Burger, D. Massotte, T.E.S. Dahms, D.T. Cramb*, Analytical Chemistry 79: 6783-6791 (2007). “Complete Blood Vessel Occlusion in the Chick Chorioallantoic Membrane using Two-Photon Excitation Photodynamic Therapy: Implications for Treatment of Wet Age-Related Macular Degeneration”, K. S. Samkoe, A. L. Clancy, B. C. Wilson, D.T. Cramb*, J. Biomed. Optics. 12: 034025-(1-14) (2007). “Fluorescence Correlation Spectroscopy using quantum dots: Advances, Challenges and Opportunities”, R.F. Heuff, J.L. Swift, D.T. Cramb*, Phys Chem Chem Phys 9: 1870-1880 (2007). Invited; Cover art. “Microporous Metal-Organic Frameworks Formed in a Stepwise Manner from Luminescent Building Blocks”, B.D. Chandler, D.T. Cramb* and G .K. H. Shimizu*, JACS 128: 10403-10412 (2006).