Gong, Bing - University at Buffalo, the State University of New York

个人简介

Education Damon Runyon-Walter Winchell Cancer Fund Postdoctoral Fellow, University of California at Berkeley, 1991-1994 PhD, The University of Chicago, 1990 BS, Sichuan University, 1984 Awards and Honors Jacob F. Schoellkopf Medal by the American Chemical Society Western New York Section, 2022 UB Distinguished Professor Award, SUNY at Buffalo 2022 Exceptional Scholar Award, SUNY at Buffalo 2019 Top 100 Federal Grantee, SUNY at Buffalo 2002 Damon Runyon-Walter Winchell Fund Postdoctoral Fellowship 1991–1994

研究领域

Research in our laboratory involves the creation of bioinspired, biomimetic, and biocompatible structures based on the combination of design, synthesis, characterization, and functional studies. The major areas of research include: protein-like folding molecules (foldamers); cavity-containing macrocycles; molecular and self-assembling nanotubes; ion and molecular channels; intramolecular delivery of ions and molecules; information-storing molecules, and the interaction of these structures, as functional molecular and supramolecular devices, with biological targets. Folding structures (porous foldamers) Pore-containing macrocyclic structures Ion and molecular channels Intracellular delivery of ions and molecules Information-storing double-stranded molecules

近期论文

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Thomas A. Sobiech, Yulong Zhong, Daniel P. Miller, Jillian K. McGrath, Christina T. Scalzo, Morgan C. Redington, Eva Zurek, Bing Gong. Ultra-Tight Host-Guest Binding with Exceptionally Strong Positive Cooperativity. Angew. Chem. Int. Ed. 2022, 61, DOI: 10.1002/anie.202213467. Sobiech, T. A.; Zhong Y. L.; Gong, B. Cavity-containing aromatic oligoamide foldamers and macrocycles: progress and future perspectives. Org. & Biomol. Chem. 2022, 20, 6962-6978. Shen, Y.; Fei, F.; Zhong, Y. L.; Fan, C. H.; Sun, J. L.; Hu, J.; Gong, B.; Czajkowsky, D.; Shao, Z. F. Controlling water flow through a synthetic nanopore with permeable cations. ACS Cent. Sci. 2021, 7, 2092-2098. Zhong, Y. L.; McGrath, J. K.; Gong B. Dipropinonates of sugar alcohols as water-soluble, nontoxic CPAs for DMSO-free cell cryopreservation. ACS Biomater. Sci. Eng. 2021, 7, 4757-4762. Sobiech, T. A.; Zhong, Y. L.; Sánchez B., L. S.; Kauffmann, B.; McGrath, J. K.; Scalzo, C.; Miller, D. P.; Huc, I.; Zurek, E.; Ferrand, Y.; Gong, B. Stable pseudo[3]rotaxanes with strong positive binding cooperativity based on shape-persistent aromatic oligoamide macrocycles. Chem Commun. 2021, 57, 11645-11648. Wang, Q. H.; Zhong, Y. L.; Miller, D. P.; Lu, X. X.; Tang, Q.; Lu, Z. L.; Zurek, E.; Liu, R.; Gong, B. Self-assembly and molecular recognition in water: Tubular stacking and guest-templated discrete assembly of water-soluble, shape-persistent macrocycles. J. Am. Chem. Soc. 2020, 142, 2915-2924. Cao, R. K.; Rossdeutcher, R. B.; Wu, X. X.; Gong, B. Oligo(5-amino-N-acylanthranilic acids): Amide Bond Formation without Coupling Reagent and Folding upon Binding Anions. Org. Lett. 2020, 22, 7496-7501. Zhong, Y. L.; Tang, Q.; Miller, D. P.; Zurek, E. D.; Liu, R.; Lu, Z. L.; Gong, B. Major Factors for the Persistent Folding of Hybrid α, β, γ-Hybrid Peptides into Hairpins. Front. Chem. 2020, 8, Article 530083. DOI: 10.3389/fchem.2020.530083.. Zhong, Y. L.; Kauffmann, B.; Xu, W. W.; Lu, Z. L.; Ferand, Y.; Huc, I.; Zeng, X. C.; Liu, R.; Gong, B. Multiturn Hollow Helices: Synthesis and Folding of Long Aromatic Oligoamides. Org. Lett. 2020, 22, 6938-6942. Tang, Q.; Zhong, Y. L.; Miller, D. P.; Liu, R.; Eva Zurek, E.; Lu, Z. L.; Gong, B. Reverse Turn Foldamers: An expanded β-turn motif reinforced by double hydrogen bonds. Org. Lett. 2020, 22, 1003-1007. Zhang, Y. K.; Zhong, Y. L.; Connor, A. L.; Miller, D. P.; Cao, R. K.; Shen, J.; Song, B.; Baker, E. S.; Tang, Q.; Pulavarti, S. V. S. R. K.; Liu, R.; Q. W.; Lu, Z. L.; Szyperski, T.; Zeng, H. Q.; Li, X. P.; Smith, R. D.; Zurek, E.; Zhu, J.; Gong, B. Folding and assembly of short α, β, γ-hybrid peptides: Minor variations in sequence and drastic differences in higher-level structures. J. Am. Chem. Soc. 2019, 141, 14239−14248. Zhao, Y. Y.; Connor, A. L.; Sobiech, T. A.; Gong, B. Effects of Oligomer Length, Solvents, and Temperature on the Self-Association of Aromatic Oligoamide Foldamers. Org. Lett. 2018, 20, 5486-5489. Shi, Y. D.; Tang, Q.; Jiang, Y. F.; Pei, Q.; Tan, H. W.; Lu, Z. L.; Gong, B. Effective formation of stable and versatile double-stranded beta-sheets templated by a hydrogen-bonded duplex. Chem. Commun. 2018, 54, 3719-3722. Zhang, Y. K.; Cao, R. K.; Shen, J.; Detchou, C. S. F.; Zhong, Y. L.; Wang, H.; Zou, S.; Huang, Q. F.; Lian, C. X.; Wang, W.; Zhu, J.; Gong, B. Hydrogen-Bonded Duplexes with Lengthened Linkers. Org. Lett. 2018, 20, 1555-1558. Zhong, Y. L.; Yang, Y.; Shen, Y.; Xu, W. W.; Wang, Q. H.; Connor, A. L.; Zhou, X. B.; He, L.; Zeng, X. C.; Shao, Z. F.; Lu, Z. L.; Gong, B. Enforced Tubular Assembly of Electronically Different Hexakis(m-phenylene ethynylene) Macrocycles: Persistent Columnar Stacking Driven by Multiple Hydrogen Bonding Interactions. J. Am. Chem. Soc. 2017, 139, 15950-15957. Hu, T.; Connor, A. L.; Miller, D. P.; Wang, X.; Pei, Q.; Liu, R.; He, L.; Zheng, C.; Zurek, E.; Lu, Z. L.; Gong, B. Helical Folding of meta-Connected Aromatic Oligoureas. Org. Lett. 2017, 19, 2666-2669. Li, X. W.; Yuan, X. Y.; Deng, P. C.; Chen, L. X.; Ren, Y.; Wang, C. Y.; Wu, L. X.; Feng, W.; Gong, B.; Yuan, L. H. Macrocyclic shape-persistency of cyclo[6]aramide results in enhanced multipoint recognition for highly efficient template-directed synthesis of rotaxanes. Chem. Sci. 2017, 8, 2091-2100. Connor, A. L.; Hu, T.; Detchou, C. S. F.; Liu, R.; Pulavarti, S. V. S. R. K.; Szyperski, T.; Lu, Z. L.; Gong, B. Aromatic Oligoureas as Hosts for Anions and Cations. Chem. Commun. 2016, 52, 9905-9908. Wei, X. X.; Zhang, G. Q.; Shen, Y.; Zhong, Y. L.; Liu, R.; Yang, N.; Al-mkhaizim, F. Y.; Kline, M.; He, L.; Li, M. F.; Lu, Z. L.; Shao, Z. F.; Gong, B. Persistent Organic Nanopores Amenable to Structural and Functional Tuning. J. Am. Chem. Soc. 2016, 138, 2749–2754. Liu, R.; Cheng, S.; Baker, E. S.; Smith, R. D.; Zeng, X. C.; Gong, B. Surprising impact of remote groups on the folding–unfolding and dimer-chain equilibria of bifunctional H-bonding unimers. Chem. Commun. 2016, 52, 3773-3776. Li, X. W.; Li, B.; Chen, L.; Hu, J. C.; Wen, C. D. Y.; Zheng, Q. D.; Wu, L. X.; Zeng, H. Q.; Gong, B.; Yuan, L. H. Liquid-Crystalline Mesogens Based on Cyclo[6]aramides: Distinctive Phase Transitions in Response to Macrocyclic Host–Guest Interactions. Angew. Chem. Int. Ed. 2015, 54, 11147–11152. Wu, X. X.; Rui Liu, R.; Sathyamoorthy, B.; Yamato, K.; Liang, G. X.; Shen, L.; Ma, S. F.; Sukumaran, D. K.; Szyperski, T.; Fang, W. H.; He, L.; Chen, X. B.; Gong, B. Discrete Stacking of Aromatic Oligoamide Macrocycles. J. Am. Chem. Soc. 2015, 137, 5879–5882. Kline, M. A.; Wei, X. X.; Horner, I. J.; Liu, R.; Chen, S.; Chen, S.; Yung, K. Y.; Yamato,K.; Cai, Z. H.; Bright, F. V.; Zeng, X. C.; Gong, B. Extremely Strong Tubular Stacking of Aromatic Oligoamide Macrocycles. Chem. Sci. 2015, 6, 152-157. Gong, B.; Shao, Z. F. Self-Assembling Organic Nanotubes with Precisely Defined, Sub-nanometer Pores: Formation and Mass Transport Characteristics. Acc. Chem. Res 2013, 46, 2856–2866.