Shi, Hang - Georgia State University

个人简介

Ph.D. Nutrition University of Tennessee at Knoxville, 2001 We are part of a new center “Center for Diagnostics and Therapeutics” with researchers that have My research interests have been focused on the molecular and cellular mechanisms of obesity and insulin resistance, with a great interest in the causative link between inflammation and insulin resistance. Specifically, I am currently interested in (a) identifying inflammatory pathways that mediate lipid/obesity-induced insulin resistance and novel endogenous anti-inflammatory mechanisms that antagonize lipid/obesity-induced insulin resistance and (b) Utilizing these insights to develop therapeutic strategies. I have a broad research background in obesity and diabetes, with specific training and expertise in key research areas such as adipocyte biology, insulin signaling, inflammatory signaling, and creation and characterization of transgenic/knockout mouse models of obesity and diabetes. I have established a variety of physiological and molecular systems for assessment of inflammatory signaling and insulin signaling in in vitro cell models and in vivo mouse models to delineate the mechanisms of obesity-induced insulin resistance. I currently study the roles of AMP-activated protein kinase (AMPK) and SIRT1 and their interaction in regulating inflammation and insulin resistance in obesity. Using in vitro cell models and various transgenic and knockout mouse models, we investigate whether AMPK and SIRT1, two classic nutrient sensors that play key roles in regulating lipid and glucose metabolism, also function as negative regulators for nutrient-induced chronic inflammation in macrophages and whether the alterations of macrophage inflammation further affect the development of insulin resistance and type 2 diabetes. A related focus of my lab is centered on epigenetic regulation of macrophage inflammation in obesity, insulin resistance and type 2 diabetes.

研究领域

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Cellular, and Molecular Biology and Physiology Group Neurobiology and Behavior Group Obesity, Insulin Resistance and Diabetes