Liu, Yuan - Georgia State University

个人简介

MD, Beijing Medical University PhD, Biochemistry & Molecular Biology, University of South Alabama Post-doctoral, Intestinal Inflammation & Leukocyte Biology, Emory University

研究领域

Research area: Cancer immunotherapy, acute and chronic inflammation, cell interactions and signaling Current projects: Macrophage phagocytic mechanisms toward cancer cells, cancer immunotherapy strategies. Neutrophil and macrophage biology and plasticity, acute and chronic inflammation and tissue neoplasia. Leukocyte cell surface protein interactions, integrins, CD47 and SIRPa

近期论文

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Bian Z, Shi L, Guo YL, Lv Z, Tang C, Niu S, Tremblay A, Venkataramani M, Culpepper C, Li L, Zhou Z, Mansour A, Zhang Y, Gewirtz A, Kidder K, Zen K and Liu Y (2016) Cd47-Sirpα interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells. Proc Natl Acad Sci USA. 2016 Sep 13;113(37):E5434-43. doi: 10.1073/pnas.1521069113. Niu S, Bian Z, Tremblay A, Luo Y, Kidder K, Mansour A, Zen K and Liu Y (2016) Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic J. Immunol. pii: 1502494. Lee YT, Ko EJ, Lee Y, Lee YN, Bian Z, Liu Y, Kang SM (2016) CD47 plays a role as a negative regulator in inducing protective immune responses to vaccination against influenza virus. Virology Jul 11;90(15):6746-58. doi: 10.1128/JVI.00605-16. Zhang Y, Li L, Liu Y, Liu ZR (2016) PKM2 Released by Neutrophils at Wound Site Facilitates Early Wound Healing by Promoting Angiogenesis. Wound Repair Regen. Jan 25. doi: 10.1111/wrr.12411. Shi L, Bian Z, Chen CX, Guo YN, Lv Z, Zeng C, Liu Z, Zen K and Liu Y (2015) CD47 deficiency ameliorates autoimmune nephritis in Fas mice by suppressing IgG autoantibody production. Pathol. Jun 12. doi: 10.1002/path.4574 Lv Z, Bian Z, Shi L, Niu S, Ha B, Tremblay A, Li L, Zhang X, Paluszynski J, Liu M, Zen K and Liu Y (2015) Loss of Cell Surface CD47 Clustering Formation and Binding Avidity to SIRPalpha Facilitate Apoptotic Cell Clearance by Macrophages. Immunol. 195:661-71. Ha B, Lv Z, Bian Z, Zhang X, Mishra A and Liu Y (2014) ‘Clustering’ SIRPα into the plasma membrane lipid microdomains is required for activated monocytes and macrophages to mediate effective cell surface interactions with CD47. PLoS One. 15;8(10). Zen K, Guo Y, Bian Z, Lv Z, Zhu D, Ohnishi H, Matozaki T and Liu Y (2013) Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory Nature Commun. 12;4:2436. doi: 10.1038/ncomms3436. Zhu D, Pan C, Li L, Bian Z, Lv Z, Shi L, Zhang J, Li D, Gu H, Zhang CY, Liu Y and Zen K (2013) MicroRNA-17/20a/106a modulate macrophage inflammatory responses through targeting signal-regulatory protein α. J Allergy Clin Immunol. 132(2):426-36. Bian Z, Guo Y, Luo Y, Tremblay A, Dharma S, Mishra A and Liu Y (2012-13) CD47 deficiency does not impede polymorphonuclear neutrophil transmigration but attenuates granulopoiesis at the postacute stage of colitis.Immunol. 2013 Jan 1;190(1):411-7. Bian Z, Guo YL, Ha B and Liu Y (2012) Regulation of the Inflammatory Response: Enhancing Neutrophil Infiltration under Chronic Inflammatory Conditions. Immunol. 188(2):844-53. Zen K, Guo YL, Li LM, Bian Z, Zhang CY and Liu Y (2011) Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis. Blood 117(18):4885-94. Chen C., Soto I. Guo YL. and Liu Y. (2011) Control of secondary granule release in neutrophils by Ral GTPase. Biol. Chem. 286(13):11724-33 Zen K, Liu DQ, Li LM, Chen CX, Guo YL, Ha B, Chen X, Zhang ZY, Liu Y. (2009) The heparan sulfate proteoglycan form of epithelial CD44V3 serves as a CD11b/CD18 counter-receptor during PMN transepithelial migration. Biol. Chem. 284(6):3768-76. Liu, Y., Tong, Q., Zhou, Y., Lee, H-W., Yang, J.J., Bühring, H-J., Chen,Y-T., Ha, B., Chen, X-J. C. Yang Y. (2007) Functional elements on SIRPa IgV domain mediate cell surface binding to CD47. Mol. Biol. 365(3):680-93. Liu, Y., O’Connor, M.B., Mandell, K.L., Burst, S.F., Ullrich, A., Bühing, Hans-Jörg and Parkos, C.A. (2004) Peptide-mediated inhibition of neutrophil transmigration by blocking CD47 interactions with SIRPa. Immunol. 172(4): 2578-2585 Shaw S.K., Ma S., Kim M.B., Rao R.M., Hartman C.U., Froio R.M., Yang L., Jones T., Liu Y., Nusrat A., Parkos C.A., Luscinskas F.W. (2004) Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration. Exp. Med. 200(12):1571-80. Zen, K., Liu, Y., McCall, I.C., Wu, T., Lee, W., Babbin, B.A., Nusrat, A., Parkos, C.A. (2005) Neutrophil Migration across Tight Junctions Is Mediated by Adhesive Interactions between Epithelial Coxsackie and Adenovirus Receptor and a Junctional Adhesion Molecule-like Protein on Neutrophils. Biol. Cell. 16(6):2694-703. Liu, Y., Soto, I., Tong, Q., Chin, A., Bühing, H-, Wu, T., Zen, K. and Parkos, C.A. (2005) SIRPb1 is expressed as a disulfide linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration. J. Biol. Chem. 280(43):36132-40. Liu, Y., Bühring, Hans-Jörg, Zen K., Schnell F.J., Williams I.R., and Parkos, C.A. (2002) Signal regulatory protein (SIRPa), a cellular ligand for CD47, regulates neutrophil transmigration. Biol. Chem. 277(12):10028-36 Liu, Y., Merlin, D., Schnell, F.J., Pochet, M. Madara J.L. and Parkos, C.A. (2001) The role of CD47 inneutrophil transmigration: Increased rate of migration correlates with increased cell surface expression of CD47. Biol. Chem. 276(43), 40156-66. Liu, Y., Nusrat, A., Schnell, F.J., Reaves, T.A., Walsh, S., Pochet, M., and Parkos, C.A. (2000) Human junction adhesion molecule regulates tight junction resealing in epithelia. Cell Sci. 113:2363-74.