Grober, Matthew - Georgia State University

研究领域

Our lab utilizes an integrative approach to study vertebrate reproductive behavior. By approaching the study of behavior at the neural, endocrine and ecological levels of analysis, we have been able to gain an understanding of the present functions, underlying mechanisms, and evolutionary history of specific behavioral traits. Our ongoing research addresses the development of sexual plasticity in teleost fishes and mammals, including species with multiple male morphs and sex change. We are interested in the integration of extrinsic cues (environmental and social) with intrinsic neuroendocrine processes. The lab employs a range of techniques, including field observations, experimental neuroanatomy, immunocytochemistry, in situ hybridization, and hormone manipulations. The current focus is on the preoptic area, a brain region involved in the early development and life-long control of reproductive behavior in all vertebrates. The goal of this work is to establish a general neuroendocrine mechanism for the development of reproductive variability as an aid in understanding the evolution and maintenance of sexual polymorphism in vertebrates.

近期论文

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Sex differences in neuromuscular androgen receptor expression and sociosexual behavior in a sex changing fish. Schuppe ER, Pradhan DS, Thonkulpitak K, Drilling C, Black M, Grober MS. PLoS One. 2017 May 16;12(5):e0177711. doi: 10.1371/journal.pone.0177711. eCollection 2017. Ancestral androgenic differentiation pathways are repurposed during the evolution of adult sexual plasticity. Schuppe ER, Solomon-Lane TK, Pradhan DS, Thonkulpitak K, Grober MS. Evol Dev. 2016 Dec;18(5-6):285-296. doi: 10.1111/ede.12207. Juvenile social status predicts primary sex allocation in a sex changing fish. Solomon-Lane TK, Shvidkaya P, Thomas A, Williams MM, Rhyne A, Rogers L, Grober MS. Evol Dev. 2016 Jul;18(4):245-53. doi: 10.1111/ede.12195. Fetuin-A is related to infarct size, left ventricular function and remodelling after acute STEMI. Feistritzer HJ, Klug G, Reinstadler SJ, Gröber MT, Mair J, Kirchmair R, Henninger B, Franz WM, Metzler B. Open Heart. 2015 Jun 26;2(1):e000244. doi: 10.1136/openhrt-2015-000244. eCollection 2015. Agonistic reciprocity is associated with reduced male reproductive success within haremic social networks. Solomon-Lane TK, Pradhan DS, Willis MC, Grober MS. Proc Biol Sci. 2015 Jul 22;282(1811). pii: 20150914. doi: 10.1098/rspb.2015.0914. Contextual modulation of social and endocrine correlates of fitness: insights from the life history of a sex changing fish. Pradhan DS, Solomon-Lane TK, Grober MS. Front Neurosci. 2015 Feb 3;9:8. doi: 10.3389/fnins.2015.00008. eCollection 2015. Review. A mechanism for rapid neurosteroidal regulation of parenting behaviour. Pradhan DS, Solomon-Lane TK, Willis MC, Grober MS. Proc Biol Sci. 2014 Jul 7;281(1786). pii: 20140239. doi: 10.1098/rspb.2014.0239. Contextual modulation of androgen effects on agonistic interactions. Pradhan DS, Connor KR, Pritchett EM, Grober MS. Horm Behav. 2014 Jan;65(1):47-56. doi: 10.1016/j.yhbeh.2013.11.006. Epub 2013 Dec 5.