Baro, Deborah - Georgia State University

个人简介

Molecular Biology University of Illinois, Chicago 1989 Cellular, Molecular Biology and Physiology Research Group Monamine Signal Transduction Dopamine is a modified aromatic amino acid. This monoamine binds to a family of G-protein coupled receptors found on neurons and other cell types, called dopamine receptors. The binding of dopamine to a dopamine receptor can trigger a variety of intracellular signaling cascades that alter neuronal function over many time scales. Dopamine release can be synaptic, paracrine or endocrine. Dopamine signaling plays a key role in nervous system function, and disruption of this signaling system is thought to underpin many pathophysiological conditions including Parkinson’s disease, schizophrenia and cocaine addiction. Cocaine causes prolonged increases in dopamine in the extracellular space. Repeated use of cocaine can lead to persistent changes in neuronal circuits. Our lab focuses on how prolonged elevations in dopamine alter voltage dependent ionic currents and lead to changes in intrinsic neuronal firing properties and circuit output. We use a variety of cellular, molecular and electrophysiological techniques to examine the direct effects of dopamine on identified neurons and to discover the physiological correlates of long-term, dopamine-induced changes in ionic currents.

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SUMOylation of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Increases Surface Expression and the Maximal Conductance of the Hyperpolarization-Activated Current. Parker AR, Welch MA, Forster LA, Tasneem SM, Dubhashi JA, Baro DJ. Front Mol Neurosci. 2017 Jan 12;9:168. doi: 10.3389/fnmol.2016.00168. eCollection 2016. Monoaminergic tone supports conductance correlations and stabilizes activity features in pattern generating neurons of the lobster, Panulirus interruptus. Krenz WD, Parker AR, Rodgers E, Baro DJ. Front Neural Circuits. 2015 Oct 20;9:63. doi: 10.3389/fncir.2015.00063. eCollection 2015. Tonic 5nM DA stabilizes neuronal output by enabling bidirectional activity-dependent regulation of the hyperpolarization activated current via PKA and calcineurin. Krenz WD, Rodgers EW, Baro DJ. PLoS One. 2015 Feb 18;10(2):e0117965. doi: 10.1371/journal.pone.0117965. eCollection 2015. Dopaminergic tone persistently regulates voltage-gated ion current densities through the D1R-PKA axis, RNA polymerase II transcription, RNAi, mTORC1, and translation. Krenz WD, Parker AR, Rodgers EW, Baro DJ. Front Cell Neurosci. 2014 Feb 17;8:39. doi: 10.3389/fncel.2014.00039. eCollection 2014. Dopaminergic tone regulates transient potassium current maximal conductance through a translational mechanism requiring D1Rs, cAMP/PKA, Erk and mTOR. Rodgers EW, Krenz WD, Jiang X, Li L, Baro DJ. BMC Neurosci. 2013 Nov 13;14:143. doi: 10.1186/1471-2202-14-143. Activation of high and low affinity dopamine receptors generates a closed loop that maintains a conductance ratio and its activity correlate. Krenz WD, Hooper RM, Parker AR, Prinz AA, Baro DJ. Front Neural Circuits. 2013 Oct 22;7:169. doi: 10.3389/fncir.2013.00169. eCollection 2013. Regulation of ephrin-A expression in compressed retinocollicular maps. Tadesse T, Cheng Q, Xu M, Baro DJ, Young LJ, Pallas SL. Dev Neurobiol. 2013 Apr;73(4):274-96. doi: 10.1002/dneu.22059. Epub 2012 Nov 28. Tonic nanomolar dopamine enables an activity-dependent phase recovery mechanism that persistently alters the maximal conductance of the hyperpolarization-activated current in a rhythmically active neuron. Rodgers EW, Fu JJ, Krenz WD, Baro DJ. J Neurosci. 2011 Nov 9;31(45):16387-97. doi: 10.1523/JNEUROSCI.3770-11.2011.