黄珺珺 - 广州医科大学

个人简介

自2006年开始，为寻找抗前列腺增生疾病（BPH）的候选新药，以国家一类新药萘哌地尔（Naftopidil）为先导物，围绕着新型α1亚型受体拮抗剂的设计、合成与活性筛选工作开展了较系统的研究。近年来发表相关研究论文十余篇，申报专利两项，主持和参与多个国家、省部级项目。

研究领域

1) 受体药物分子设计、合成与活性筛选 2) 活性先导物的发现、作用机制与SAR研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Junjun Huang*, Zhihan Zhang, Fei He, Xiawen Liu, Xingjie Xu, Lijun Dai, Qimeng Liu, Mu Yuan*, Novel naftopidil derivatives containing methyl phenylacetate and their blocking effects on α1D/1A-adrenoreceptor subtypes, Bioorganic & Medicinal Chemistry Letters, Vol 28, No 4, PP. 547–551, February, 2018 2.Wei Xu, Junjun Huang, Renwang Jiang*, Mu Yuan*, Crystal structures, absolute configurations and molecular docking studies of naftopidil enantiomers as α1D-adrenoceptor antagonists, Acta Pharmaceutica Sinica B, Vol 7, No 4, pp. 496-501, March, 2017 3.Honggui Lv#, Jingjing Shi#, Junjun Huang, Chao Zhang, Wei Yi*, Rhodium(III)-catalyzed and meOH-involved regioselective mono-alkenylation of N-arylureas with acrylates, Organic&Biomolecular Chemistry, Vol 15, No 34, pp. 7088-7092, July, 2017 4.JunJun Huang*, Yi Cai, MinYi Huang, Liu Zhu, Fei He, XiaWen Liu, BiYun Huang, YanZhenYi, Mu Yuan*, Pharmaceutical evaluation of naftopidil enantiomers: Rat functional assays in vitro and estrogen/androgen induced rat benign prostatic hyperplasia model in vivo, European Journal of Pharmacology, Vol 791, No 15, pp. 473–481, September, 2016 5.Wei Xu#, Junjun Huang# (Co-first author), Binhao Shao, Xingjie Xu, Renwang Jiang*, Mu Yuan*, Design, synthesis, crystal structure, biological evaluation and molecular docking studies of carbazole-arylpiperazine derivatives, Bioorganic & Medicinal Chemistry, Vol 24, No 21, pp. 5565–5572, November, 2016 6.Junjun Huang#, Fei He#, Minyi Huang, Xiawen Liu, Yan Xiong, Yajian Huang, Liu Zhu, Ya Yang, Xingjie Xu, Mu Yuan*, Novel naftopidil-related derivatives and their biological effects as alpha1-adrenoceptors antagonists and antiproliferative agents, European Journal of Medicinal Chemistry, Vol 96, No 26, pp. 83-91, May, 2015 7.Wei Xu, Junjun Huang, Binhao Shao, Xingjie Xu, Renwang Jiang, Mu Yuan*, X-ray crystallography, DFT calculations and molecular docking of indole-arylpiperazine derivatives as α1A-adrenoceptor antagonists, Molecules, Vol 20, No 11, pp. 19674-19689, October, 2015 8.Junjun Huang, Yajian Huang, Liu Zhu, Mu Yuan*, Design, synthesis and α1-adrenoreceptor blocking activity of new arylpiperazine containing acetophenone substituents, Pharmazie, Vol 69, No 8, pp. 578-584, January, 2014