刘夏雯 - 广州医科大学

个人简介

2013年7月于广州医科大学博士毕业，同年进入广州医科大学药物研发中心工作，方向为药物代谢。2007年起对系列抗BPH手性新药的质量研究，体内外手性分析方法开发验证，体内外吸收分布代谢排泄进行了系统研究。参与多个中药活性成分体内外代谢机制研究。目前主要研究方向为药物与内源分子与代谢酶相互作用。主持国家基金及市级基金各一项，参与国家及省市级多个项目。发表文章数十篇。

研究领域

1. 新药开发中药物的体内外药代动力学研究 2. 小分子与代谢酶的相互作用机制研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Xiawen Liu, Yi Rong, Xingfei Zhang, Junjun Huang, Yi Cai, Biyun Huang, Liu Zhu, Bo Wu, Ning Hou, Chengfeng Luo. Human UDP-Glucuronosyltransferase 2B4 and 2B7 are responsible for naftopidil glucuronidation in Vitro. Frontiers in Pharmacology. 2018, 8, doi: 10.3389/fphar.2017.00984. 2. Xiawen Liu, Lijun Zhu, Biyun Huang, Junjun Huang, Yi Cai, Liu Zhu, Bo Wu, Xiaojing Fu, Xingfei Zhang, Yi Rong, Qing Xiao, Jiewen Guo, Arong Li, Yifei Guo, Mu Yuan. Poor and enantioselective bioavailability of naftopidil enantiomers is due to extensive and stereoselective metabolism in rat liver. Journal of Pharmaceutical and Biomedical Analysis. 2017, 132, pp 165-172. 3. Yi Rong, Biyun Huang, Junjun Huang, Liu Zhu, Xiawen Liu(通讯). A rapid and simple ultraperformance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) method for the detection of glucuronic acid-conjugated steroid metabolites. Journal of Chinese Pharmaceutical Sciences. 2016, 25(4), pp 291-301. 4. Xiawen Liu, Xingfei Zhang, Junjun Huang, Yi Rong, Chengfeng Luo, Jiewen Guo, Liu Zhu, Biyun Huang, Mu Yuan*. Enantiospecific determination of naftopidil by RRLC-MS/MS reveals stereoselective pharmacokinetics and tissue distributions in rats. Journal of Pharmaceutical and Biomedical Analysis. 2015, 112: 147-154（IF: 2.979） 5. Lijun Zhu†, Xiawen Liu†, Liu Zhu, Xingfei Zhang, Xiaojing Fu, J unjun Huang, Mu Yuan*. Identification of human cytochrome P450 isozymes involved in the metabolism of naftopidil enantiomers in vitro. Journal of Pharmacy and Pharmacology. 2014, 66(11):1534-1551 (IF: 2.264) 6. Yunying Zhang†, Xiawen Liu†, Mu Yuan*, Lijun Zhu. Simultaneous stereoselective analysis of naftopidil and O-desmethyl naftopidil enantiomers in rat feces using an online column-switching high performance liquid chromatography method. Journal of Biomedical Chromatography. 2014, 28:1030-1035 (IF: 1.723) 7. Xiawen Liu, Yunying Zhang, Mu Yuan*, Yinxiang Sun. Determination of Naftopidil enantiomers in rat plasma using chiral solid phases and pre-column derivatization high performance Liquid Chromatography. Journal of Chromatography B. 2012 (907) 140-145. (IF: 2.694) 8. Xiawen Liu, Hong Ji, Mu Yuan*. Comparison of different polysaccharide-based chiral stationary phases for enantioselective resolution of naftopidil and its derivatives by HPLC. Journal of Chinese Pharmaceutical Scienses. 2010 (19) 293-299.