周毅 - 广州医科大学

个人简介

广州医科大学，药学院药剂学教研室主任，副教授；广州医科大学优秀教师；中国药理学会委员，广东省制药委员会委员，广东省肿瘤委员会委员，广东省药事管理委员会常委；广东省科技特派员；Molecular Pharmaceutics，Biochemical Pharmacology，International Journal of Pharmaceutics等杂志的特邀评委。本人2012.1-2012.6在美国艾奥瓦大学药学院从事博士后工作。到目前为止，发表SCI论文20余篇，影响因子达110分。主持参加多项国家及省市级课题。申请专利2项，授权1项。副主编药学本科实验教材1部；与无限极（中国）有限公司及广药集团保持常年合作关系。开发并完成SYZ胶囊；保济片，东风桔口服液，益妇宁软胶囊，格列齐特缓释片等产品。

研究领域

1.智能给药；2.肿瘤耐药性的治疗机制研究；3.中药六类新药的开发。

近期论文

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① Yi Zhou#, Huaying Wen#, Liang Gu, Jijun Fu, Jiayi Guo, Lingran Du, Xiaoqin Zhou, Xiyong Yu, Yugang Huang, He Wang*. Aminoglucose-Functionalized and Redox-Responsive Polymer Nanomicelles for Overcoming Chemoresistance in Lung Cancer Cells. Journal of Nanobiotechnology, 11, 28 ;15(1) , 2017 (IF=4.95, 生物工程技术二区) ②Junwei Huang#, Yi Zhou#, Gregory S Thomas, Zhimin Gu, Ye Yang, Hongwei Xu, Guido Tricot*, Fenghuang Zhang*. NEDD8 inhibition overcomes CKS1B induced drug resistance by upregulation of p21 in prostate cancer. Clinical Cancer Research, 21: 5532-42, 2015 (IF=9.52，肿瘤二区) ③ Yi Zhou, He Wang, Chengxi Wang, YongNan Jiang, Wenfen Lu, Shuifang Chen, Jianbing Zhao, Le Lai, Yuan Ping, Jianhai Chen*. Receptor–mediated, tumor-targeted gene delivery using folate-terminated polyrotaxanes. Mol. Pharmaceutics, 9, 1067-1076, 2012 (IF=4.52, 药学二区) ④ Yi Zhou, Jian-hai Chen，He Wang, Jian-ye Zhang, Cheng-xi Wang, Yi-wen Tao, Guo-dong Zheng, Hong-yan Xie, Yi Zhou*. Synthesis and characterization of folate-poly(ethylene glycol) chitosan graft-polyethylenimine as a non-viral carrier for tumor-targeted gene delivery. African Journal of Biotechnology, 4: 6120-6129. 2011 (IF=0.6) ⑤ Yi Zhou，He Wang, Lei Liang, Wenchan Zhao, Yan Chen, Hongzhu Deng*. Total alkaloid of Sophora Alopecuroides increases the expression of CD4+CD25+ Tregs and IL-10 in rats of experimental colitis. The American Journal of Chinese Medicine, 38(2): 251-263. 2010 (IF=3.5) ①Yazhong Ge, Qing Gao, Fengjiao Yan, Xiaona Zhang, Yurong Liu, Yi Zhou*.Su Yang Decoction Induces Human Colon Carcinoma Cell Apoptosis by Activating Caspases. Oncology letters, 2018, 5 ②He Wang#, Mingna Sun#, Jiayi Guo, Lei Ma, Hui Jiang, Liang Gu, Huaying Wen, Siyan Liao, Jingqi Chen, Bohang Zeng, Yongmei Li, Yueshan Li, Xiyong Yu, Yinghong Feng*, Yi Zhou*. 3-O-(Z)-coumaroyloleanolic acid overcomes Cks1b-induced chemoresistance in lung cancer by inhibiting Hsp90 and MEK pathways. Biochemical Pharmacology, 7, 135-145, 2017 (IF=4.72, 药学一区) ③He Wang#, Henghui Yin, Fengjiao Yan, Mingna Sun, Lingran Du, Wei Peng, Qiuli Li , Yinghong Feng, Yi Zhou*. Folate-mediated mitochondrial targeting with doxorubicin polyrotaxane nanoparticles overcomes multidrug resistance. Oncotarget, 6, 2827-42, 2015. (IF=5.12，肿瘤二区) ④He Wang#, Shu Yang#, Hong Zhou, Mingna Sun, Lingran Du, Minyan Wei, Meixia Luo, Jingzhu Huang, Hongzhu Deng, Yinghong Feng, Jun Huang, Yi Zhou*. Aloperine executes antitumor effects against multiple myeloma through dual apoptotic mechanisms. Journal of Hematology and Oncology, 8:26, 2015. (IF=6.32，肿瘤二区) ⑤He Wang#, Hong Zhou#, Cheng-Xi Wang, Yue-Shan Li, Hong-Yan Xie, Jian-Dong Luo, Yi Zhou*. Paeoniﬂorin inhibits growth of human colorectal carcinoma HT 29 cells in vitro and in vivo. Food and Chemical Toxicology, 50, 1560–1567, 2012. (IF=3.77，毒理二区)