张海宁 - 广州医科大学

个人简介

2004年毕业于中山大学基础医学院药理学专业，获医学博士学位。2006年于中山大学眼科中心结束博士后训练，期间主要从事F4/80+细胞参与前房相关免疫偏离（anterior chamber associated immune deviation, ACAID）诱导、形成机制及对葡萄膜炎的预防作用的研究。2006年于广州医学院药理教研室任职，担任教学和科研工作。承担研究生、留学生、本科生等药理学、机能实验学的教学。主要从事内源性肾上腺糖皮质激素参与心衰过程中炎症反应的调节的研究。2010年八月至2012年八月，于加拿大曼尼托巴大学从事博士后研究工作，主要研究方向为PPARs抑制心肌肥大的信号通路。目前主要研究方向为慢性心力衰竭的发病机制。主持或参与广东省自然科学、广州市教育局项目、国家自然科学基金等多项项目。发表研究论文数十篇，其中SCI收录论文11篇。

研究领域

慢性心力衰竭的发病机制

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Zhang H, Shao Z, Alibin CP, Acosta C, Anderson HD*. Liganded Peroxisome Proliferator-Activated Receptors (PPARs) Preserve Nuclear Histone Deacetylase 5 Levels in Endothelin-Treated Sprague-Dawley Rat Cardiac Myocytes.PLoS One. 2014 Dec 16;9(12):e115258. 2. Zhang HN#, He YH#, Zhang GS, Luo MS, Huang Y, Wu XQ, Liu SM, Luo JD*, Chen MS. Endogenous glucocorticoids inhibit myocardial inflammation induced by lipopolysaccharide: involvement of regulation of histone deacetylation. J Cardiovasc Pharmacol. 2012 Jul;60(1):33-41. 3. Zhang H, He Y, Zhang G, Li X, Yan S, Hou N, Xiao Q, Huang Y, Luo M, Zhang G, Yi Q, Chen M, Luo J.HDAC2 is required by the physiological concentration of glucocorticoid to inhibit inflammation in cardiac fibroblasts.Can J Physiol Pharmacol. 2017 Sep;95(9):1030-1038. 4. He YH#, Zhang HN#, Zhang GP, Hou N, Xiao Q, Huang Y, Wu JH, Luo MS, Zhang GS, Yi Q, Chen MS, Luo JD*. A physiological concentration of glucocorticoid inhibits the pro-inflammatory cytokine-induced proliferation of adult rat cardiac fibroblasts: roles of extracellular signal-regulated kinase 1/2 and nuclear factor-κB. Clin Exp Pharmacol Physiol. 2011，38（11）：739-46. 5. Huang Y, Zhang H, Shao Z, O'Hara KA, Kopilas MA, Yu L, Netticadan T, Anderson HD*. Suppression of endothelin-1-induced cardiac myocyte hypertrophy by PPAR agonists: role of diacylglycerol kinase zeta. Cardiovasc Res. 2011; 90(2): 267-275. 6. Zhang GS, Wang RJ, Zhang HN, Zhang GP, Luo MS, Luo JD*. Effects of chronic treatment with honokiol in spontaneously hypertensive rats. Biol Pharm Bull. 2010;33(3): 427-31. 7. Hou N, Luo MS, Liu SM, Zhang HN, Xiao Q, Sun P, Zhang GS, Luo JD*, Chen MS. Leptin induces hypertrophy through activating the peroxisome proliferator-activated receptor α pathway in cultured neonatal rat cardiomyocytes.Clin Exp Pharmacol Physiol. 2010 Nov;37(11):1087-95. 8. Zhang H, Yang P*, Zhou H, Meng Q, Huang X. Involvement of Foxp3-expressing CD4(+) CD25(+) regulatory T cells in the development of tolerance induced by transforming growth factor-beta(2)-treated antigen-presenting cells. IMMUNOLOGY. 2008;124(3): 304-314. 9. Hai-Ning Zhang#, Jia-Guo Zhou#, Qin-Ying Qiu, Jing-Li Ren, Yong-Yuan Guan*. ClC-3 chloride channel prevents apoptosis induced by thapsigargin in PC12 cells. Apoptosis. 2006;11：327-336 . 10. Hai-feng SONG, Xiu-wen LIU, Hai-ning ZHANG, Bao-zhen ZHU, Shou-jun YUAN, Shang-yi LIU, Zhong-ming TANG*. Pharmacokinetics of His-tag recombinant human endostatin in Rhesus monkeys. Acta Pharmacol Sin 2005 Feb; 26 (2): 124-128. 11. Qianli Meng, peizeng yang*, Haoli Jin, James T. Rosenbaum, Bing Li, Haining Zhang, Hongyan Zhou, Xiangkun Huang, and Stephen R. Planck. Phenotypes, Distribution, and Morphological Features of Antigen-presenting Cells in the Murine Cornea following Intravitreal Injection. Mol Vis 2007 Mar 28;13:475-486.