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个人简介

2009年进入北京大学医学部,师从著名心血管专家王宪教授攻读博士学位。2012年博士毕业后前往美国奥克拉荷马大学医学部和佐治亚州立大学分子和转化医学中心,跟随美国医学科学院院士、国际心血管及代谢疾病领域知名专家邹明辉教授从事博士后研究。

研究领域

长期致力于从巨噬细胞及炎症因子角度研究血管性疾病的病理机制,包括①动脉粥样硬化(Atherosclerosis, As)、②血管钙化、③胰岛素抵抗、④脓毒症的免疫及炎性机制。

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1.Dai X, Okon I, Liu Z, Bedarida T, Wang Q, Ramprasath T, Zhang M, Song P, Zou MH (*). Ablation of Neuropilin 1 in Myeloid Cells Exacerbates High-Fat Diet-Induced Insulin Resistance Through Nlrp3 Inflammasome In Vivo. Diabetes. 2017 Sep; 66(9):2424-2435. 2.Dai X, Okon I, Liu Z, Wu Y, Zhu H, Song P, Zou MH (*). A novel role for myeloid cell-specific neuropilin 1 in mitigating sepsis. FASEB J. 2017 Jul; 31(7):2881-2892. 3.Dai X, Ding Y, Liu Z, Zhang W, Zou MH (*). Phosphorylation of CHOP (C/EBP Homologous Protein) by the AMP-Activated Protein Kinase Alpha 1 in Macrophages Promotes CHOP Degradation and Reduces Injury-Induced Neointimal Disruption In Vivo. Circ Res. 2016 Oct 28; 119(10):1089-1100. 4.Dai XY, Cai Y, Sun W, Ding Y, Wang W, Kong W, Tang C, Zhu Y, Xu MJ (*), Wang X. Intermedin inhibits macrophage foam-cell formation via tristetraprolin-mediated decay of CD36 mRNA. Cardiovasc Res. 2014 Feb 1; 101(2):297-305. 5.Dai XY (#), Zhao MM (#), Cai Y, Guan QC, Zhao Y, Guan Y, Kong W, Zhu WG, Xu MJ (*), Wang X. Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release. Kidney Int. 2013 Jun;83(6):1042-51. 6.Dai XY, Cai Y, Mao DD, Qi YF, Tang C, Xu Q, Zhu Y, Xu MJ (*), Wang X (*). Increased stability of phosphatase and tensin homolog by intermedin leading to scavenger receptor A inhibition of macrophages reduces atherosclerosis in apolipoprotein E-deficient mice. J Mol Cell Cardiol. 2012 Oct; 53(4):509-20. 7.Zhao Y (#), Dai XY (#), Zhou Z, Zhao GX, Wang X, Xu MJ (*). Leucine supplementation via drinking water reduces atherosclerotic lesions in apoE null mice. Acta Pharmacol Sin. 2016 Feb; 37(2):196-203. 8.Liu Z, Zhu H, Dai X, Wang C, Ding Y, Song P, Zou MH (*). Macrophage Liver Kinase B1 Inhibits Foam Cell Formation and Atherosclerosis. Circ Res. 2017 Oct 13; 121(9):1047-1057. 9.Wang Q, Wu S, Zhu H, Ding Y, Dai X, Ouyang C, Han YM, Xie Z (*), Zou MH (*). Deletion of PRKAA triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of DNM1L. Autophagy. 2017 Jan; 13:1-19. 10.Zhu H, Zhang M, Liu Z, Xing J, Moriasi C, Dai X, Zou MH (*). AMP-Activated Protein Kinase α1 in Macrophages Promotes Collateral Remodeling and Arteriogenesis in Mice In Vivo. Arterioscler Thromb Vasc Biol. 2016 Sep; 36(9):1868-78. 11.Liu Z, Dai X, Zhu H, Zhang M, Zou MH (*). Lipopolysaccharides Promote S-Nitrosylation and Proteasomal Degradation of Liver Kinase B1 (LKB1) in Macrophages in Vivo. J Biol Chem. 2015 Jul 31; 290(31):19011-7. 12.Wu Y, Song P, Zhang W, Liu J, Dai X, Liu Z, Lu Q, Ouyang C, Xie Z, Zhao Z, Zhuo X, Viollet B, Foretz M, Wu J, Yuan Z (*), Zou MH (*). Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo. Nat Med. 2015 Apr; 21(4):373-82. 13.Zhang W, Wang Q, Wu Y, Moriasi C, Liu Z, Dai X, Wang Q, Liu W, Yuan ZY, Zou MH (*). Endothelial cell-specific liver kinase B1 deletion causes endothelial dysfunction and hypertension in mice in vivo. Circulation. 2014 Apr 1; 129(13):1428-39. 14.Song P, Zhou Y, Coughlan KA, Dai X, Xu H, Viollet B, Zou MH (*). Adenosine monophosphate-activated protein kinase-α2 deficiency promotes vascular smooth muscle cell migration via S-phase kinase-associated protein 2 upregulation and E-cadherin downregulation. Arterioscler Thromb Vasc Biol. 2013 Dec; 33(12):2800-9. 15.Zhao G (#), Xu MJ (#), Zhao MM, Dai XY, Kong W, Wilson GM, Guan Y, Wang CY (*), Wang X (*). Activation of nuclear factor-kappa B accelerates vascular calcification by inhibiting ankylosis protein homolog expression. Kidney Int. 2012 Jul; 82(1):34-44. 16.Dai XY, Ou X, Hao XR, Cao DL, Tang YL, Hu YW, Li XX, Tang CK*. The effect of T0901317 on ATP-binding cassette transporter A1 and Niemann-Pick typeC1 in apoE-/- mice. J Cardiovasc Pharmacol. 2008 May; 51(5):467-75. 17.Ou X#, Dai X#, Long Z, Tang Y, Cao D, Hao X, Hu Y, Li X, Tang C*. Liver X receptor agonist T0901317 reduces atherosclerotic lesions in apoE-/- mice by up-regulating NPC1 expression. Sci China C Life Sci. 2008 May; 51(5):418-29. 18.Dai X, Ou X, Hao X, Cao D, Tang Y, Hu Y, Li X, Tang C (*). Synthetic liver X receptor agonist T0901317 inhibits semicarbazide-sensitive amine oxidase gene expression and activity in apolipoprotein E knockout mice. Acta Biochim Biophys Sin (Shanghai). 2008 Mar; 40(3):261-8. 19.Dai X, Ou X, Hao X, Cao D, Tang Y, Hu Y, Li X, Tang C (*). Effect of T0901317 on hepatic proinflammatory gene expression in apoE-/- mice fed a high-fat/high-cholesterol diet. Inflammation. 2007 Aug;30(3-4):105-17. 20.Dai X, Okon I, Zou MH. Myeloid cell neuropilin 1 ameliorates high-fat diet-induced insulin resistance via suppression of Nlrp3 inflammasome. Macrophage (Houst). 2017;4. pii: e1594.

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