个人简介
广州市首批“羊城学者”科研资助计划青年科研骨干、广东省首批广东省高等学校优秀青年教师培养计划培养对象、广东省“特支计划”百千万人才工程青年拔尖人才、南山学者骨干人才。2004年—2009年在中山大学攻读硕博连读研究生获医学博士学位。2006年—2008年赴美国贝勒医学院医学系进修。2009年进入广州医科大学省重点学科药理学教研室至今。主要从事心血管药理学研究。目前,作为项目负责人主持国家自然科学基金2项及省市级课题多项。近五年发表SCI论文十余篇,其中以第一作者发表10篇。代表作发表在心血管病权威杂志Arterioscler Thromb Vasc Biol。
研究领域
自噬与心脏、血管病理性重构的发病机制及传统中药单体和小分子化合物的药物干预治疗研究
近期论文
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1. Wu XQ# ,Zheng D, Qin Y, Liu Z, Zhang G, Zhu X, Zeng L, Liang Z. Nobiletin attenuates adverse cardiac remodeling after acute myocardial infarction in rats via restoring autophagy flux. Biochem Biophys Res Commun. 2017 Oct 14;492(2):262-268. 2. Wu XQ#, He LS#, Chen FJ, He XE, Cai Y, Zhang GP, Yi Q, He MX, Luo JD. Impaired autophagy contributes to adverse cardiac remodeling in acute myocardial infarction. PLoS One. 2014;9(11):e112891. 3. Wu XQ#,He LS#,Cai Y, Zhang GP, He YL, Zhang ZJ, He XE, He YH, Zhang GS, Luo JD. Induction of Autophagy Contributes to the Myocardial Protection of Valsartan against Ischemia-Reperfusion Injury. Molecular Medicine Report,2013;8(6):1824-30 4. Cai Y, Zhao L, Qin Y, Wu XQ(co-corresponding) . EGCG Blocked Phenylephrin-Induced Hypertrophy in H9C2 Cardiomyocytes, by Activating AMPK-Dependent Pathway. Korean J Physiol Pharmacol. 2015 May; 19(3): 203–210. 5. Wu XQ, Cheng JZ, Li P, Yang M, Qiu SL, Liu PQ, Du J. Mechano-sensitive transcriptional factor Egr-1 regulates insulin-like growth factor-1 receptor expression and contributes to neointima formation in vein grafts. Arterioscler Thromb Vasc Biol. 2010;30(3):471-6. 6. Wu XQ, Huang HQ, Tang FT, Le K, Xu SW, Liu PQ. Regulated expression of endothelial lipase in atherosclerosis. Mol Cell Endocrinol. 2010; 315(1-2):233-8. 7. Wang P#, Wu XQ#, Bao YX, Fang J, Zhou SG, Gao J, Pi R, Mou YG, Liu PQ. Tanshinone IIA prevents cardiac remodeling through attenuating NAD (P)H oxidase- derived reactive oxygen species production in hypertensive rats. Pharmazie 2011;66(7):517-24. 8. Cheng J, Truong LD, Wu XQ, Kuhl D, Lang F, Du J. Serum- and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition. Kidney Int. 2010;78(7):668-78 9. Jiang Q, Liu P, Wu XQ, Liu W, Shen X, Lan T, Xu S, Peng J, Xie X, Huang H. Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: Involvement of NF-kappaB signaling pathway. Mol Cell Endocrinol. 2011 1;331(1):34-40 10. Le K, Li R, Xu S, Wu XQ, Huang H, Bao Y, Cai Y, Lan T, Moss J, Li C, Zou J, Shen X, Liu P PPARα activation inhibits endothelin-1-induced cardiomyocyte hypertrophy by prevention of NFATc4 binding to GATA-4. Arch Biochem Biophys. 2012 Feb 1;518(1):71-8. 11. Xu S, Little PJ, Lan T, Huang Y, Le K, Wu XQ, Shen X, Huang H, Cai Y, Tang F, Wang H, Liu P.Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in apolipoprotein-E knockout mice fed a high cholesterol diet. Arch Biochem Biophys. 2011 Nov;515(1-2):72-9 12. Zhang HN, He YH, Zhang GS, Luo MS, Huang Y, Wu XQ, Liu SM, Luo JD, Chen MS. Endogenous glucocorticoids inhibit myocardial inflammation induced by lipopolysaccharide: involvement of regulation of histone deacetylation. J Cardiovasc Pharmacol. 2012 Jul;60(1):33-41