易伟 - 广州医科大学

个人简介

中山大学-法国格勒一大联合培养博士毕业；2011年7月，加入中国科学院上海药物研究所，历任博士后、助理研究员、副研究员、徐华强课题组药物化学部负责人。2016年11月以“高水平研究型”引进人才身份加入广州医科大学，现为广州医科大学药学院特聘教授、中科院青年创新促进会会员、中国药学会会员、中国药理学会会员、中国化学会会员，2015年度赛诺菲·安万特-中国科学院上海生命科学研究院优秀青年科学家奖及2017年广东省杰出青年基金获得者。其主要研究方向为以结构为基础、功能为导向的创新药物设计与发现。至今，易伟博士已在Nature、Cell Res.、ACS Catal.、Org. Lett.、Chem. Commun.等国际权威杂志发表SCI收录研究论文50余篇，其中第一作者及通讯作者近40篇，被引用率超过1500次，H指数为25；申请国内外发明专利10余项-其中，其负责的以GR为靶点的抗炎症、哮喘新药开发项目（PCT专利：WO/2015/048361 A1）已成功实施转让，总金额达5100万余元（人民币）；作为负责人或学术骨干承担了多项国家或省部级项目如国家科技部“973”计划、广东省杰出青年基金、国家自然基金重点项目和青年基金、国家博士后基金面上项目及特别资助、上海市自然基金面上项目。

研究领域

1) 基于结构的药物设计与发现 2) 基于过渡金属催化C-H活化策略的药物及活性分子导向合成

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1) X. Xu, R. Sun, S. Zhang, X. Zhang* and W. Yi*. Divergent Synthesis of Quinolones and Dihydroepindolidiones via Cu(I)-Catalyzed Cyclization of Anilines with Alkynes. Org Lett., 2018, DOI: 10.1021/acs.orglett.8b00436. (IF = 6.579，一区) 2) W. Wu#, Y. Guo#, F. X. Xu#, Z. Zhou, X. Zhang*, B. Wu* and W. Yi*. One-pot regioselective synthesis of 2,4-disubstituted quinolines via copper(II)-catalyzed cascade annulation. Org. Chem. Front., 2018, DOI: 10.1039/C8QO00052B. (IF = 4.955，二区) 3) W. Gong#, Z.Zhou#, J. Shi#, B. Wu, B. Huang and W. Yi*. Catalyst-Controlled [3 + 2] and [4 + 2] Annulations of Oximes with Propargyl Alcohols: Divergent Access to Indenamines and Isoquinolines. Org. Lett., 2018, 20, 182-185. (IF = 6.579，一区) 4) X. Xu, Y. Yang, X. Zhang* and W. Yi*. Direct Synthesis of Quinolines via Co(III)-Catalyzed and DMSOInvolved C−H Activation/Cyclization of Anilines with Alkynes. Org. Lett., 2018, 20, 566-569. (IF = 6.579，一区) 5) S. Song, A. You, Z. Chen*, G. Zhu, H. Wen, H. Song* and W. Yi*. Study on the design, synthesis and structure-activity relationships of new thiosemicarbazone compounds as tyrosinase inhibitors. Eur. J. Med. Chem., 2017, 139, 815-825. (IF = 4.519，二区) 6) W. Yi*,#, J. Shi#, G. Zhao#, X. E. Zhou, K. Suino-Powell, K. Melcher and H. E. Xu*. Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro. Sci. Rep., 2017, 7, 41487. (IF = 4.257，二区) 7) X. Xu, Y. Yang, X. Chen, X. Zhang* and W. Yi*. The one-pot synthesis of quinolines via Co(III)-catalyzed C–H activation/carbonylation/cyclization of anilines. Org. Biomol. Chem., 2017, 15, 9061-9065. (IF = 3.564，二区) 8) H. Lv#, J. Shi#, B. Wu, Y. Guo, J. Huang and W. Yi. One-pot synthesis of 2,3-difunctionalized indoles via Rh(III)-catalyzed carbenoid insertion C–H activation/cyclization. Org. Biomol. Chem., 2017, 15, 8054-8058. (IF = 3.564，二区) 9) H. Lv#, J. Shi#, J. Huang, C. Zhang and W. Yi. Rhodium(III)-catalyzed and MeOH-involved regioselective mono-alkenylation of N-arylureas with acrylates. Org. Biomol. Chem., 2017,15, 7088-7092. (IF = 3.564，二区) u 以前代表性论文： 1) C. Chen#, J. Ke#, X. E. Zhou, W. Yi, et al. Structural basis for molecular recognition of folic acid by folate receptors. Nature, 2013, 500, 486-9. (IF = 40.137，一区) 2) L. Jiang#, X. Liu#, G. Xiong#, H. Liu#, F. Chen, L. Wang, X. Meng, G. Liu, H. Yu, Y. Yuan, W. Yi, et al. DWARF 53 acts as a repressor of strigolactone signaling in rice. Nature, 2013, 504, 401-5. (IF = 40.137, 一区) 3) L.-H. Zhao#, X. E. Zhou#, W. Yi#, et al. Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3. Cell Res., 2015, 25, 1219-36. (IF = 14.812，一区) 4) Y. He*, W. Yi*, et al. Structures and mechanism for the design of highly potent glucocorticoids. Cell Res., 2014, 24, 713-726. (IF = 14.812，一区) 5) J. Zhou, J. Shi, Z. Qi, X. Li*, H. E. Xu and W. Yi*. Mild and efficient Ir(III)-catalyzed direct C-H alkynylation of N-phenoxyacetamides with terminal alkyne. ACS Catal., 2015, 5, 6999-7003. (IF = 10.614，一区) 6) X. Zhang*, Z. Wang, K. Xu, Y. Feng, W. Zhao, X. Xu, Y. Yan and W. Yi*. HOTf-catalyzed sustainable one-pot synthesis of benzene and pyridine derivatives under solvent-free conditions. Green Chem., 2016, 18, 2313-2316. (IF = 9.125，一区) 7) X. Zhang, X. Xu, G. Chen and W. Yi*. Regioselective Synthesis of 2,3,4-Trisubstituted Pyrroles via Pd(II)-Catalyzed Three-Component Cascade Reactions of Amines, Alkyne Esters, and Alkenes. Org Lett., 2016, 18, 4864-4867. (IF = 6.579，一区) 8) J. Shi, J. Zhou, Y. Yan, J. Jia, X. Liu, H. Song, H. E. Xu* and W. Yi*. One-pot cascade synthesis of N-methoxyisoquinolinediones via Rh(III)-catalyzed carbenoid insertion C–H activation/cyclization. Chem. Commun., 2015, 51, 668-671. (IF = 6.32，一区) 9) J. Jia, J. Shi, J. Zhou, X. Liu, Y. Song, H. E. Xu* and W. Yi*. Rhodium(III)-catalyzed C–H activation and intermolecular annulation with terminal alkynes: from indoles to carbazoles. Chem. Commun., 2015, 51, 2925-2928. (IF = 6.32，一区) 10) J. Zhou, J. Shi, X. Liu, J. Jia, H. Song, H. E. Xu* and W. Yi*. Rh(III)-catalyzed and alcohol-involved carbenoid C–H insertion into N-phenoxyacetamides using α-diazomalonates. Chem. Commun., 2015, 51, 5868-5871. (IF = 6.32，一区) 11) J. Shi, Y. Yan, Q. Li, H. E. Xu* and W. Yi*. Rhodium(III)-catalyzed C2-selective carbenoid functionalization and subsequent C7-alkenylation of indoles. Chem. Commun., 2014, 50, 6483-6486. (IF = 6.32，一区)