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个人简介

2000年在北京大学药学院获得药学学士;2003年在北京大学(天然药物与仿生药物国家重点实验室)获得生药学硕士学位;2003-2005年从事新药研究与开发;2008年在中山大学(华南肿瘤学国家重点实验室)获得肿瘤学博士;2012-2014年在香港浸会大学中医药学院进行两年的访问学者研究。兼任中国抗癌协会抗癌药物专业委员会委员,中国药理学会肿瘤药理专业委员会委员,世界中医药联合会精准医学专业委员会委员,世界中医药联合会中药化学专业委员会理事,世界中医药联合会中药新药创制专业委员会理事。广东省药理学会肿瘤药理专业委员会常委。担任国家、省市基金通讯评审。申请授权专利多项,发表多篇SCI文章。

研究领域

中药/天然药物的抗肿瘤研究,基于肿瘤标志物的抗癌新药及机制研究

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

[1] Wang K#, Li J#, Ji S*, Li L, Qiu Z, Pan C, Zhang J*, Huo Y*. Fluorescence probes based on AIE luminogen: application for sensing Hg2+ in aqueous media and cellular imaging. New Journal of Chemistry. 2018, DOI: 10.1039/c8nj02245c. [2] Zhang JY*, Huang WJ, Sun HM, Liu Y, Zhao XQ, Tang SL, Sun MN, Wang S, Li JJ, Zhang LL, Zhou JH, Pan QR, Chen HB*. Structure Identification and In Vitro Anticancer Activity of Lathyrol-3-phenylacetate-5,15-diacetate. Molecules. 2017, 22(9). pii: E1412. doi: 10.3390/molecules22091412. [3] Zhang J#, Lai Z#, Huang W, Ling H, Lin M, Tang S, Liu Y, Tao Y. Apicidin Inhibited Proliferation and Invasion and Induced Apoptosis via Mitochondrial Pathway in Non-small Cell Lung Cancer GLC-82 Cells. Anti-Cancer Agents in Medicinal Chemistry. 2017, 17(10): 1374-1382. [4] Lin M, Bi H, Yan Y, Huang W, Zhang G, Zhang G, Tang S, Liu Y, Zhang L, M J, Zhang J*. Parthenolide Suppresses Non-Small Cell Lung Cancer GLC-82 Cells Growth via B-Raf/MAPK/Erk Pathway. Oncotarget. 2017, 8(14): 23436-23447. [5] Lin M, Tang S, Zhang C, Chen H, Huang W, Liu Y, Zhang J*. Euphorbia factor L2 induces apoptosis in A549 cells through the mitochondrial pathway. Acta Pharmaceutica Sinica B. 2017, 7(1): 59-64. [6] Zhang JY, Lin MT, Tung HY, Tang SL, Yi T, Zhang YZ, Tang YN, Zhao ZZ, Chen HB*. Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway. American Journal of Cancer Research. 2016, 6(4): 819-826. [7] Tao YW, Lin YC, She ZG, Lin MT, Chen PX, Zhang JY*. Anticancer activity and mechanism investigation of beauvericin isolated from secondary metabolites of the mangrove endophytic fungi. Anti-Cancer Agents in Medicinal Chemistry. 2015, 15(2): 258-266. [8] Zhang JY, Lin MT, Zhou MJ, Yi T, Tang YN, Tang SL, Yang ZJ, Zhao ZZ, Chen HB. Combinational Treatment of Curcumin and Quercetin against Gastric Cancer MGC-803 Cells in Vitro. Molecules. 2015, 20(6): 11524-11534. [9] Zhang JY, Lin MT, Yi T, Tang YN, Fan LL, He XC, Zhao ZZ, Chen HB*. Apoptosis sensitization by Euphorbia factor L1 in ABCB1-mediated multidrug resistant K562/ADR cells. Molecules. 2013, 18(10): 12793-12808. [10] Zhang JY, Yi T, Liu J, Zhao ZZ, Chen HB*. Quercetin Induces Apoptosis via the Mitochondrial Pathway in KB and KBv200 Cells. Journal of Agricultural and Food Chemistry. 2013, 61(9): 2188–2195. [11] Zhang JY*, Liang YJ, Chen HB, Zheng LS, Mi YJ, Wang F, Zhao XQ, Wang XK, Zhang H, Fu LW*. Structure identification of Euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway. Molecules. 2011, 16(4): 3222-3231. [12] Zhang JY, Mi YJ, Chen SP, Wang F, Liang YJ, Zheng LS, Shi CJ, Tao LY, Chen LM, Chen HB, Fu LW*. Euphorbia factor L1 reverses ABCB1-mediated multidrug resistance involving interaction with ABCB1 independent of ABCB1 downregualtion. Journal of Cellular Biochemistry. 2011, 112(4): 1076-1083. [13] Zhang JY, Tao LY, Liang YJ, Chen LM, Mi YJ, Zheng LS, Wang F, She ZG, Lin YC, To KK, Fu LW*. Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi. Marine Drugs. 2010, 8(4): 1469-1481. [14] Zhang JY, Tao LY, Liang YJ, Yan YY, Dai CL, Xia XK, She ZG, Lin YC, Fu LW*. Secalonic acid D induced leukemia cell apoptosis and cell cycle arrest of G1 with involvement of GSK-3beta/beta-catenin/c-Myc pathway. Cell Cycle. 2009, 8(15): 2444-2450. [15] Zhang JY, Wu HY, Xia XK, Liang YJ, Yan YY, She ZG, Lin YC, Fu LW. Anthracenedione derivative 1403P-3 induces apoptosis in KB and KBv200 cells via reactive oxygen species-independent mitochondrial pathway and death receptor pathway. Cancer Biology & Therapy. 2007, 6(9): 1413-1421. [16] Zhu L, Liang ZT, Yi T, Ma Y, Zhao ZZ, Guo BL, Zhang JY, Chen HB. Comparison of chemical profiles between the root and aerial parts from three Bupleurum species based on a UHPLC-QTOF-MS metabolomics approach. BMC Complementary and Alternative Medicine. 2017, 17(1): 305. [17] Tang YN, Pang YX, He XC, Zhang YZ, Zhang JY, Zhao ZZ, Yi T, Chen HB. UPLC-QTOF-MS identification of metabolites in rat biosamples after oral administration of Dioscorea saponins: A comparative study. Journal of Ethnopharmacology. 2015 165: 127-40. [18] Fang JY, Zhu L, Yi T, Zhang JY, Yi L, Liang ZT, Xia L, Feng JF, Xu J, Tang YN, Zhao ZZ, Chen HB. Fingerprint analysis of processed Rhizoma Chuanxiong by high-performance liquid chromatography coupled with diode array detection. Chinese Medicine. 2015, 10: 2. doi: 10.1186/s13020-015-0031-3.

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