个人简介
胡文辉博士，现任广州医科大学药学院特聘教授，药物化学专业博士生导师，兼学术委员会主任，广东省分子靶标与临床药理重点实验室副主任,呼吸病国家重点实验室研究员。胡博士于2002年毕业于中国协和医科大学药物研究所，师从郭宗儒教授，开展抗炎药物的研究，获得博士学位。2002年-2006年在美国西北大学医学院从事博士后研究,开展神经退行性疾病的药物研究。2006年-2016年在中国科学院广州生物医药与健康研究院历任副研究员、研究员、新药开发室主任。
近期论文
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1. Hui Xie, Shaogao Zeng, Yuwen He, Guicheng Zhang, Pengjiu Yu, Guifa Zhong, Hongjiang Xu, Ling Yang, Shanchun Wang, Xin Zhao*, Wenhui Hu*. Rapid generation of a novel DPP-4 inhibitor with long-acting properties: SAR study and PK/PD evaluation. European Journal of Medicinal Chemistry, 2017, 141, 519-529. (IF=4.5) 2. Yunlong Zhao, Qingxin Zhao, LS Wang, Wen Hui Hu*, Jun Ling Zhao*. Organocatalytic Friedel-Crafts Alkylation /Lactonization Reaction of Naphthols with 3-Trifluoroethylidene Oxindoles: The Asymmetric Synthesis of Dihydrocoumarins. Angewandte Chemie International Edition. 2017, 56, 338 –342. (IF =12.0) 3. Wei Zhou, Guifa Zhong, Sihai Fu, Hui Xie, Tianyan Chi, Luyi Li, Xiurong Rao，Shaogao Zeng, Dengfeng Xu, Hao Wang, Guoqing Sheng, Xing Ji, Xiaorong Liu, Xuefei Ji, Donghai Wu, Libo Zou, Micky Tortorella, Kejian Zhang, and Wenhui Hu*. Microglia-based phenotypic screening identifies a novel inhibitor of neuroinflammation effective in Alzheimer's Disease Models. ACS Chemical Neuroscience. 2016, Nov 16;7 (11):1499-1507. (IF =3.9) 4. Jianghong Dong, Shengwei Chen, Runfeng Li, Wei Cui, Haiming Jiang, Yixia Ling, Zifeng Yang, Wenhui Hu*. Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus. European Journal of Medicinal Chemistry. 2016, 108, 605-615. (IF=4.5) 5. Shengwei Chen, Qinxin Lou, Yuyang Ding, Shasha Zhang, Wenhui Hu* and Junling Zhao* Organocatalytic enantioselective Michael reaction of malononitrile to b,b-disubstituted nitroalkenes. Advanced Synthesis & Catalysis. 2015, 357, 2437-2441. (Front Cover and Very Important Publication). (IF =5.6) 6. Shengwei Chen, Guicheng Zhang, Qxinxin Lou, Wei Cui, Shasha Zhang, Wenhui Hu* and Junling Zhao*. Organocatalytic enantioselective aza-Michael reaction of benzotriazole to β,β-disubstituted nitroalkenes. ChemCatChem. 2015, 7, 1935-1938. (Inside Back Cover). (IF =4.8) 7. Yuyang Ding, Liufeng Mao, Dengfeng Xu, Hui Xie, Ling Yang, Hongjiang Xu, Wenjun Geng, Yong Gao, Chunguang Xia, Xiquan Zhang, Qingyi Meng, Donghai Wu, Junling Zhao * and Wenhui Hu*. C-aryl glucoside SGLT2 inhibitors containing a biphenyl motif as potential anti-diabetic agents. Bioorganic Medinal Chemistry letter. 2015, 25, 2744-2748. (IF =2.8) 8. Bo Bi, Qin-Xin Lou, Yu-Yang Ding, Sheng-Wei Chen, Sha-Sha Zhang, Wen-Hui Hu* and Jun-Ling Zhao* Chiral phosphoric acid-catalyzed highly enantioselective Friedel-Crafts alkylation reaction of C3-substituted indoles to unsaturated ketimino esters. Organic Letters, 2015, 17, 540−543. (IF =6.6) 9. Wei Cui, Shengwei Chen, JiaQiang Wu, Xin Zhao*,Wenhui Hu*, and Honggen Wang*, Palladium-Catalyzed Remote C(sp3)−H Arylation of 3‑Pinanamine. Organic Letters. 2014, 16, 4288−4291. (IF =6.6) 10. 周渭, 胡文辉*. 神经炎症抑制剂用于阿尔茨海默症的药物研发. 科学通报. 2014. 59(3): 232 - 237. （封面文章） 11. Wei Zhou, Wenhui Hu*. Anti-neuroinflammatory agents for the treament of Alzheimer’s disease. Future Medicinal Chemistry. 2013.5 (13): 1-13. (IF =3.6) 12. Hui Xie, Lili Zeng, Shaogao Zeng, Xin Lu, Xin Zhao, Guicheng Zhang, Zhengchao Tu, Hongjiang Xu, Ling Yang, Xiquan Zhang, Shanchun Wang*, Wenhui Hu*. Highly potent dipeptidyl peptidase IV inhibitors derived from Alogliptin through pharmacophore hybridization and lead optimization. European Journal of Medicinal Chemistry. 2013, 68, 312-320. (IF=4.5) 13. Shaogao Zeng, Hui Xie, L-li Zeng, Xin Lu, Xin Zhao, Gui-cheng Zhang, Zhengchao Tu, Hongjiang Xu, Ling Yang, Xiquan Zhang, Wenhui Hu*. Discovery of potent dipeptidyl peptidase IV inhibitors through pharmacophore hybridization and hit-to-lead optimization. Bioorganic & Medicinal Chemistry. 2013. 21(7):1749-55. (IF=2.9) 14. Xin Zhao, Yanling Jie, Matthew R. Rosenberg, Junting Wan, Shaogao Zeng, Wei Cui, Yiping Xiao, Zhiyuan Li, Zhengchao Tu, Marco G. Casarotto, Wenhui Hu*. Design and Synthesis of Pinanamine Derivatives as Anti-Influenza A M2 Ion Channel Inhibitors. Antiviral Research. 2012, 96(2):91-99. (IF=4.3) 15.Wei Zhou, Guifa Zhong, Xiurong Rao, Hui Xie, Shaogao Zeng, Tianyan Chi, Libo Zou, Donghai Wu, Wenhui Hu*. Identification of aminopyridazine-derived anti-neuroinflammatory agents effective in an alzheimer’s mouse model. ACS Medicinal Chemistry Letters. 2012, 3 (11): 903–907. (IF=3.7)
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