余细勇 - 广州医科大学

个人简介

医学博士、二级教授（药理学）、南山学者杰出人才，硕士生导师（1997年起）、博士生导师（2002年起）和博士后合作导师（2005年起），曾先后留学于香港大学医学院和美国贝勒医学院从事博士后研究工作。1989-2014年在广东省人民医院（广东省医学科学院）工作，2015年5月调到广州医科大学。现任广州医科大学药学院院长，广州分子与临床药理研究所所长，呼吸疾病国家重点实验室PI及药理学组组长、广东省分子靶标与临床药理学重点实验室主任，广东艾贝珐生物医药研究院院长，华南药物临床评价中心主任，广东省临床药物分析测试工程技术研究中心主任，粤港澳大湾区国家级医药研发平台项目负责人主要社会兼职中国病理生理学会心血管专业委员会主任委员、中国病理生理学会常务理事、国际心脏研究会中国分会副主席、ISHR中国转化医学工作委员会共同名誉主任委员；中华医学会心血管分会基础学组委员、中国医师协会心血管医师分会转化医学组委员；中国药理学会表观遗传药理学专业委员会主任委员、中国药理学会常务理事、中国药理学会临床药理专业委员会常委、中国药理学会心血管药理专业委员会常委、中国药理学会分子与生化药理专业委员会常委、广东省药理学会理事长/名誉理事长，中国GCP联盟早期临床/BE试验专委会副主任委员，华南生物医药创新研发技术服务联盟理事长；广东省中西医结合学会副会长、中国中西医结合学会理事；国家973计划第四届健康科学领域咨询组专家，国家自然科学基金二审专家。

研究领域

分子临床药理学、表观遗传药理学、干细胞药理学、肿瘤心脏病学

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Wang J, Jiang X, Zhao L, Zuo S, Chen X, Zhang L, Lin Z, Zhao X, Qin Y, Zhou X, Yu XY*. Lineage reprogramming of fibroblasts into induced cardiac progenitor cells by CRISPR/Cas9-based transcriptional activators. Acta Pharmaceutica Sinica B, 2019, doi: 10.1016/j.apsb.2019.09.003 Zhang LM, Wang P, Xie YZY, Wang L, Deng S, Qin AP, Yu XY*, Zheng WF*, and Jiang XY. Triple Targeting Delivery of CRISRP/Cas9 to Reduce the Risk of Cardiovascular Diseases. Angew Chem Int Edit. 2019；58(36):12404-12408 Zhou Z, Bian MY, Zhao LX, Hui Gao H, Huang JJ, Liu XW, Yu XY*, Li XW, Yi W*. 2H‑Chromene-3-carboxylic Acid Synthesis via Solvent-Controlled and Rhodium(III)-Catalyzed Redox-Neutral C−H Activation/[3+3] Annulation Cascade. Org Lett. 2018, 20(13): 3892-3896. Shao LB, Zhang Y, Pan XB, Liu B, Liang C, Zhang YQ, Wang YL, Yan B, Xie WP, Sun Y, Shen ZY, Yu XY, Li Y. Knockout of beta‑2 microglobulin enhances cardiac repair by modulating exosome imprinting and inhibiting stem cell‑induced mmune rejection. Cell Mol Life Sci. 2019; doi: 10.1007/s00018-019-03220-3 Cheng H, Fan JH, Zhao LP, Fan GL, Zheng RR, Qiu XZ, Yu XY, Li SY, Zhang XZ. Chimeric peptide engineered exosomes for dual-stage light guided plasma membrane and nucleus targeted photodynamic therapy. Biomaterials. 2019; 211: 14-24. Han CS, Zhou J, Liu B, Liang C, Pan XB, Zhang Y, Zhang YQ, Wang YL, Shao LB, Zhu B, Wang JJ, Yin Q, Yu XY, Li Y*. Delivery of miR-675 by stem cell-derived exosomes encapsulated in silk fibroin hydrogel prevents aging- induced vascular dysfunction in mouse hindlimb. Mater Sci Eng C Mater Biol Appl. 2019; 99: 322–332. Zhu B, Zhang LL, Liang C, Liu B, Pan XB, Wang YL, Zhang YQ, Zhang Y, Xie WP, Yan B, Liu F, Yip HK, Yu XY, Li Y*. Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF-κB/TNF-α Signaling Pathway. Oxid Med Cell Longev. 2019; 2019:9739258 Han C., Zhou J., Liang C., Liu B., Pan X., Zhang Y., Wang Y., Yan B., Xie W., Liu F., Yu XY, Li Y, Human umbilical cord mesenchymal stem cell derived exosomes encapsulated in functional peptide hydrogel promote cardiac repair. Biomater. Sci., 2019;7(7):2920-2933 Cheng H, Fan GL, Fan JH, Zhao LP, Zheng RR, Yu XY*, Li SY*. Ratiometric theranostic nanoprobe for pH imaging-guided photodynamic therapy. Nanoscale. 2019;11(18):9008-9014. Cheng H, Fan GL, Fan JH, Zheng RR, Zhao LP, Yuan P, Zhao XY, Yu XY, Li SY. A Self-Delivery Chimeric Peptide for Photodynamic Therapy Amplified Immunotherapy. Macromol Biosci. 2019;19(4):e1800410. Cheng H, Zheng RR, Fan GL, Fan JH, Zhao LP, Jiang XY, Yang B, Yu XY*, Li SY*, Zhang XZ. Mitochondria and plasma membrane dual-targeted chimeric peptide for single-agent synergistic photodynamic therapy. Biomaterials. 2019; 188:1-11. Cheng H, Jiang XY, Zheng RR, Zuo SJ, Zhao LP, Fan GL, Xie BR, Yu XY, Li SY*, Zhang XZ. A biomimetic cascade nanoreactor for tumor targeted starvation therapy-amplified chemotherapy. Biomaterials. 2019;195:75-85. Ruan Z, Huang Z, Xu Z, Mo G, Tian X, Yu XY, Ackermann L. Catalyst-Free, Direct Electrochemical Tri- and Difluoroalkylation/Cyclization: Access to Functionalized Oxindoles and Quinolinones. Org Lett. 2019;21(4):1237-1240. Zheng GD, Hu PJ, Chao YX, Zhou Y, Yang XJ, Chen BZ, Yu XY*, Cai Y*. Nobiletin induces growth inhibition and apoptosis in human nasopharyngeal carcinoma C666-1 cells through regulating PARP-2/SIRT1/AMPK signaling pathway. Food Sci Nutr. 2019;7(3):1104-1112. Huang W, Fen YL, Liang JL, Yu H, Jiang L, Paul C, Yu XY*, Wang Y*. Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration. Nat Commun. 2018; 9:700. Yu XY, Song P, Zou MH. Obesity Paradox and Smoking Gun: A Mystery of Statistical Confounding. Circ Res. 2018; 122:1642-1644. Fu JJ, Zhang JY, Li SP, Zhang LM, Lin ZX, Liang L, Qin AP*, Yu XY*. CuS nanodot-loaded thermosensitive hydrogel for anticancer photothermal therapy. Molecular Pharmaceutics. 2018; 15(10):4621-4631. Zhou Z, Bian MY, Zhao LX, Hui Gao H, Huang JJ, Liu XW, Yu XY*, Li XW, Yi W*. 2H‑Chromene-3-carboxylic Acid Synthesis via Solvent-Controlled and Rhodium(III)-Catalyzed Redox-Neutral C−H Activation/[3+3] Annulation Cascade. Org Lett. 2018, 20(13):3892-3896. Li SY, Jiang XY, Zheng RR, Zuo SJ, Zhao LP, Fan GL, Fan JH, Liao YH, Yu XY*，Cheng H*. An azobenzene-based heteromeric prodrug for hypoxia-activated chemotherapy by regulating subcellular localization. Chem Commun. 2018; 54(57):7983-7986. IF 6.319 Bao M, Liu S, Yu XY, Wu C, Chen Q, Ding H, Shen C, Wang B, Wang S, Song YH, Li Y. Runx1 promotes satellite cell proliferation during ischemia - Induced muscle regeneration. Biochem Biophys Res Commun. 2018;503(4):2993-2997. IF 2.559 Zhang Y, Pan X, Sun Y, Geng YJ, Yu XY, Li Y. The Molecular Mechanisms and Prevention Principles of Muscle Atrophy in Aging. Adv Exp Med Biol. 2018; 1088:347-368. IF1.76 Li SP, Lin ZX, Jiang XY, Yu XY*. Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools. Acta Pharmacol Sin. 2018; 39:1–7.