Jun, Wang - University at Albany-SUNY - Department of Chemistry

个人简介

Jun Wang is an Assistant Professor in the Department of Chemistry at SUNY Albany. Prior to joining SUNY Albany, he received postdoctoral training in the Department of Chemistry and the NanoSystems Biology Cancer Center at the California Institute of Technology. His research in Prof. James Heath's group includes one-step, self-powered blood chip and 2D barcode microarray for single-cell proteomics. He discovered that cell communications make cancer cells more heterogeneous and cause their resistance to targeted drug treatment. He obtained his Ph.D. in Biological Engineering from Purdue University where his research in Prof. Chang Lu's group was focused on single-cell microfluidics and gene delivery. He employed electroporation to differentially release intracellular proteins and invented the first flow cytometry that sorts cells according to the subcellular location of signaling proteins. He has received several top awards including Chorafas Foundation prize.

研究领域

Our group is focused on development of multiplex biotechnologies based on nanotechnology and microfluidics, particularly barcode microarray, for disease diagnostics and forensic investigation. This unique lab also aims to apply the multiplex tools and employ principles in systems biology and physics to tackle the major challenges in immunology and cancer therapeutics, and to offer new perspectives of multi-scale biosystem development.

近期论文

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Wang, J.*, Kravchenko-Balasha, N.*, Levine, R. D, Heath, J. R. Glioblastoma cellular architectures are predicted through knowledge of two-cell interactions. PNAS, 111(2014) 6521-6526. (IF=9.7; *co-first author) Nathanson, D., Gini, B., Mottahedeh, J., Visnyei, K., Koga, T., Gomez, G., Eskin, A., Hwang, K., Wang, J., et al. Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science, 343(2014) 72-76. (IF=31.0) Wei, W., Shin, Y. S., Ma, C., Wang, J., Elitas, M., Fan, R., Heath, J.R. Microchip platforms for multiplex single-cell functional proteomics with applications to immunology and cancer research. Genome Medicine, 5(2013) 75-81. (IF=3.9) Dooraghi, A. A., Vu, N. T., Silverman, R. W., Farrell, R., Shah, K. S., Wang, J., Heath, J. R. and Chatziioannou, A. F. Betabox: a beta particle imaging system based on a position sensitive avalanche photodiode. Physics in Medicine and Biology, 58(2013) 3739-3753. (IF=2.8) Wang, J., Tham, D., Ahmad, H., Ma, C., Yu, J.-K., Heath, J. R. Quantitating cell-cell interaction functions, with applications to glioblastoma multiforme cancer cells. Nano Letters, 12(2012) 6101-6106. (IF=13.1) Wang, J., Kwang, K.W., Brass, D., Radu, C., Christofk, H., Phelps, M., Heath, J. R. Fast metabolic response to drug intervention through analysis on a miniaturized, highly integrated molecular imaging system. Journal of Nuclear Medicine, 54(2013) 1820-1824. (IF=6.4) Zhan, Y., Cao, Z., Bao, N., Li, J., Wang, J., Geng, T., Lin, H., Lu, C. Low-frequency ac electroporation shows strong frequency dependence and yields comparable transfection results to dc electroporation. Journal of Controlled Release 160 (2012) 570-576. (IF=6.5) Wang, J.*, Zhan, Y.*, Bao, N., Lu, C. Quantitative measurement of quantum dot uptake at the cell population level using microfluidic evanescent-wave-based flow cytometry. Lab on a Chip, 12 (2012) 1441-1445. (IF=6.3; * co-first author) Geng, T., Zhan, Y., Wang, J., Lu, C. Transfection of cells using flow-through electroporation based on constant voltage. Nature Protocols 6 (2011) 1192-1208. (IF=9.9) Vermesh, U*., Vermesh, O.*, Wang, J., Kwong, G. A., Ma, C., Hwang, K., Heath, J. R. High-density, multiplexed patterning of cells at single-cell resolution for tissue engineering and other applications. Angewandte Chemie International Edition 32 (2011) 7378-7380. (IF=13.5) Wang, J., Ahmad, H., Ma, C., Shi, Q. -H., Vermesh, O., Vermesh, U. and Heath, J. R. A self-powered, one-step chip for rapid, quantitative and multiplexed detection of proteins from pinpricks of whole blood. Lab on a Chip 10 (2010) 3157-3162. (IF=6.3) Wang, J., Zhan, Y., Ugaz, V. M and Lu, C. Vortex-assisted DNA delivery. Lab on a Chip 10 (2010) 2057-2061. (IF=6.3) Wang, J., Fei, B., Zhan, Y., Geahlen, R. L. and Lu, C. Kinetics of NF-kappaB nucleocytoplasmic transport probed by single-cell screening without imaging. Lab on a Chip 10 (2010) 2911-2916. (IF=6.3) Wang, J., Fei, B., Geahlen, R. L. and Lu, C. Quantitative analysis of protein translocations by microfluidic total internal reflection fluorescence flow cytometry. Lab on a Chip 10 (2010) 2673-2679. (IF=6.3) Zhan, Y., Wang, J., Bao, N., and Lu, C. Electroporation of cells in microfluidic droplets. Analytical Chemistry 81 (2009) 2027-2031. (IF=5.8) Wang, J., Bao, N., Paris, L. L., Geahlen, R. L. and Lu, C. Total internal reflection fluorescence flow cytometry. Analytical Chemistry 80 (2008) 9840-9844. (IF=5.8) Wang, J., Bao, N., Paris, L. L., Wang, H. -Y., Geahlen, R. L. and Lu, C. Detection of kinase translocation using microfluidic electroporative flow cytometry. Analytical Chemistry 80 (2008) 1087-1093. (IF=5.8) Bao, N., Wang, J. and Lu, C. Recent advances in electric analysis of cells in microfluidic systems. (Invited review) Analytical and Bioanalytical Chemistry 391 (2008) 933-942. (IF=3.8) Bao, N., Wang, J. and Lu, C. Microfluidic electroporation for selective release of intracellular molecules at the single cell level. Electrophoresis 29 (2008) 2939-2944. (IF=3.3) Wang, F., Wang, H., Wang, J., Wang, H. Y., Rummel, P. L., Garimella, S. V. and Lu, C. Microfluidic delivery of small molecules into mammalian cells based on hydrodynamic focusing. Biotechnology and Bioengineering 100 (2008) 150-158. (IF=3.9)