朱新建 - 东南大学

研究领域

癫痫是一种具有产生反复多次癫痫发作的持久倾向性的神经系统疾病。近年来我国癫痫的发病率仍呈上升趋势，然而迄今为止，癫痫疾病仍缺乏有效的药物预防和治疗措施，因此，癫痫疾病发病机制的深入研究将为寻找癫痫疾病的潜在药物靶点提供理论基础。关于癫痫的发病机制目前已有大量的研究，在分子水平，目前普遍认为癫痫相关基因表达紊乱可引起脑内兴奋性递质与抑制性递质失衡和离子通道功能异常，导致细胞内信号过度激活和神经元兴奋性异常增高，从而引发癫痫疾病的发生；在细胞水平，癫痫可引起脑内海马结构的损伤，如海马神经元丢失、星形胶质细胞活化、神经元再生、苔藓纤维发芽、炎症反应等的产生，而这些海马结构损伤是异常兴奋性突触环路形成的重要原因，可促进形成难治性癫痫。本课题组通过药理学、细胞生物学、分子生物学等实验技术，结合细胞与动物模型，致力于在细胞和分子水平阐明调控癫痫疾病发生的作用机制，旨在为癫痫疾病的药物治疗提供理论依据，并为癫痫疾病的治疗开拓新的视角。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Zhu X, Li X, Zhu M, Xu K, Yang L, Han B, Huang R, Zhang A, Yao H., Metalloprotease Adam10suppresses epilepsy through repression of hippocampal neuroinflammation. J Neuroinflammation. 2018;15 (1):221. 2. Zhu X, Dong J, HanB, Huang R, Zhang A, Xia Z, Chang H, Chao J, Yao H., Neuronal nitric oxidesynthase contributes to PTZ kindling epilepsy-induced hippocampal endoplasmic reticulum stress and oxidative damage.Front Cell Neurosci. 2017;11:377. 3. Zhu X, Dong J, HanB, Huang R, Zhang A, Xia Z, Chang H, Chao J, Yao H., Neuronal nitric oxidesynthase contributes to PTZ kindling-induced cognitive impairment and depressive-like behavior. Front Behav Neurosci. 2017;11:203. 4. Zhu X, Dong J, Xia Z,Zhang A,Chao J, Yao H., Repeatedrestraint stress increases seizure susceptibility by activation of hippocampalendoplasmic reticulum stress. Neurochem Int. 2017;110:25-37. 5.杨展能,姜靓婧，顾仕红，陈磊，黎虹薇，朱新建*. NMDA受体在匹罗卡品癫痫小鼠海马星形胶质细胞活化中的作用. 东南大学学报（医学版）. 2017,36(2):129-136. 6. Zhu X, Shen K, Bai Y,Zhang A, Xia Z, Chao J, Yao H., NADPHoxidase activation is required for pentylenetetrazole kindling-induced hippocampal autophagy. Free Radic BiolMed. 2016;94:230-42. 7. Zhu X, Dong J, ShenK, Bai Y, Chao J, Yao H., Neuronal nitric oxide synthase contributes topentylenetetrazole kindling -induced hippocampal neurogenesis. Brain Res Bull. 2016,24 (1), 33-42. 8. Zhu X, Dubey D, Bermudez C, Porter BE*., Suppressing cAMP response element binding protein transcription shortens the duration of statusepilepticus and decreases the number of spontaneous seizures in the pilocarpinemodel of epilepsy. Epilepsia. 2015, 56(12):1870-1078. 9. Zhu X, Dong J, Shen K, et al. NMDA receptor NR2B subunits contribute toPTZ-kindling induced hippocampal astrocytosis andoxidative stress. Brain Res Bull.2015, 114:70-78. 10. Bai Y, Zhu X, Chao J., et al. Pericytes contribute to the disruption of the cerebral endothelialbarrier via increasing VEGF expression: implications for stroke.PLoSOne. 2015,10(4):e0 124362. 11. Zhu X, Han X, Blendy JA, et al. Decreased CREB levelssuppress epilepsy. Neurobiol Dis. 2012, 45:253-263. 12. Varodayan FP, Zhu XJ,Cui XN, Porter BE. Seizures increase cell proliferation in the dentategyrus by shortening progenitor cell-cycle length. Epilepsia. 2009, 50: 2638-2647. 13. Xin Jian Zhu, You Ming Lu, Dong Ya Zhu.Neuronal selfrepair following ischemic insults.Central nervous system Agents in Medicinal Chemistry. 2007,7:79-84. 14. Luo CX, Zhu XJ, Zhou QG et al. Reduced neuronal nitric oxide synthase is involved inischemia-induced hippocampal neurogenesis by up- regulating inducible nitricoxide synthase expression. J Neurochem. 2007,103:1872-1882. 15. Luo CX, Jiang J, Zhou QG, Zhu XJ, Wang W et al. Voluntary exercise-induced neurogenesis in thepostischemic dentate gyrus is associated with spatial memory recovery fromstroke. J Neurosci Res. 2007, 85:1637-1646. 16. Lin X, Zhang Y, Dong J, Zhu X, Ye M et al. GM-CSF enhances neural differentiation of bone marrowstromal cells.Neuroreport. 2007, 16:1113-1117. 17. Zhou QG, Hu Y,Hua Y, Hu M, Luo CX, Han X, Zhu XJ et al. Neuronalnitric oxide synthase contributes to chronic stress-induced depression bysuppressing hippocampal neurogenesis.J Neurochem. 2007,103:1843-1854. 18. Zhu XJ, Hua Y, Jiang J et al. Neuronal NOS-derived NO inhibits neurogenesis in the adult DG bydown-regulating CREB phosphorylation. Neuroscience. 2006,141:827-836. 19. Luo CX, Zhu XJ, Zhang AX et al. Blockade of L-type voltage-gated Ca2+channel inhibits ischemia-induced neurogenesis by down-regulating iNOSexpression in adult mouse. J Neurochem. 2005, 94:1077-1086.