武秋立 - 东南大学

研究领域

1.模式生物纳米毒理研究武秋立课题组近年来一直在致力于利用秀丽线虫动物模型围绕纳米毒理学效应中的关键科学问题，针对重要工程纳米材料的安全性评价及其致毒效应机制研究开展了系统性研究工作，并已取得了一系列研究成果。以秀丽线虫作为毒性测试生物，构建了完整系统的急性、慢性、神经、生殖毒性等毒理学评价与研究的替代模型，并应用于常用工程纳米材料毒理学评价与研究；证明该评价体系在环境相关剂量ENMs毒效应评价的重要价值，并为如何降低和预防ENMs毒性提出有效的策略；同时明确界定了纳米材料动物体内初级与次级靶器官，建立了秀丽线虫靶器官毒理学研究体系，为系统揭示了纳米材料致毒效应系统细胞与分子作用机制鉴定基础。该研究工作可极大地丰富纳米技术安全评估技术，有助于评价与解决现实环境纳米材料暴露毒效应，为纳米材料在医学领域和环境修复等领域的进一步开发和利用提供重要参考。2. 模式生物免疫调控研究秀丽线虫因其基因背景研究清楚，信号通路与哺乳动物具有保守性，并且只有固有免疫，已经成为免疫研究广泛使用的模式生物。武秋立课题组针对免疫调控在具体生物学事件中的作用机制，利用秀丽线虫开展系统基础研究。

近期论文

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1.Qiuli Wu, et al. Genome-wide identification and functional analysis of long noncoding RNAs involved in the response to grapheneoxide. Biomaterials. 2016, 102: 277-291.(IF:8.387) 2.Qiuli Wu, et al. Quantum dots increased fat storage in intestine of Caenorhabditiselegansby influencing molecular basis for fatty acid metabolism. Nanomedicine: Nanotechnology, Biology, and Medicine. 2016;12 1175–84.(IF:5.978) 3.Qiuli Wu, et al. Genetic Screen Reveals Link between the Maternal Effect Sterile Gene mes-1 andPseudomonas aeruginosa-inducedNeurodegenerationin Caenorhabditis elegans.The Journal of biological chemistry. 2015, 290(49): 29231-29239. (IF:4.258) 4.Qiuli Wu, et al.microRNAscontrol of invivotoxicity from grapheneoxide in Caenorhabditiselegans.Nanomedicine:Nanotechnology, Biology, and Medicine. 2014, 10(7):1401-1410.(IF:5.978) 5.Qiuli Wu, et al. Molecular signals regulating translocation and toxicity of grapheneoxide in the nematode Caenorhabditiselegans.Nanoscale.2014, 6(19):11204-11212. (IF:6.739) 6.Qiuli Wu, et al. Immune response is required for the control of in vivo translocation andchronic toxicity of grapheneoxide. Nanoscale.2014, 6(11):5894-5906. (IF:6.739) 7.Qiuli Wu,et al.Susceptible genes regulate the adverse effects of TiO2-NPs at predictedenvironmental relevant concentrations on nematode Caenorhabditiselegans. Nanomedicine:Nanotechnology, Biology, and Medicine. 2014, 10(6):1263-1271.(IF:5.978) 8.Qiuli Wu,et al. Contributions of altered permeability of intestinal barrier anddefecation behavior to toxicity formation from grapheneoxide in nematode Caenorhabditiselegans.Nanoscale,2013, 5(20): 9934-9943. (IF:6.739) 9.Qiuli Wu, et al.Crucial role of biological barrier at the primary targeted organs incontrolling translocation and toxicity of multi-walled carbon nanotubesin nematode Caenorhabditiselegans. Nanoscale,2013, 5: 11166-11178. (IF:6.739) 10.Qiuli Wu, et al. Comparison of toxicities from three metal oxide nanoparticlesat environmental relevant concentrations in nematode Caenorhabditiselegans.Chemosphere, 2013, 90: 1123-1131. (IF:3.499)