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研究领域

1、噪声暴露对听觉系统及非听觉系统的损伤效应及机制研究 2、认知/情绪行为异常的神经机制研究

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[1] LiuLJ, Huang Y, Fang C, Zhang HY, Yang J, Xuan CY, Wang FF, Lu HY, Cao SF, WangYF, Li SW, Sha J, Zha MM, Guo M, Wang J: Chronic noise-exposure exacerbatesinsulin resistance and promotes the manifestations of the type 2 diabetes in ahigh-fat diet mouse model. PloS one 2018, 13:16. [2] Liu LJ, Fang C, Yang J, Zhang HY, Huang Y, XuanCY, Wang YF, Li SW, Sha J, Zha MM, Guo M: The effect of noise exposure oninsulin sensitivity in mice may be mediated by the JNK/IRS1 pathway.Environmental health and preventive medicine 2018, 23:8. [3] Liu L, Xuan C, Shen P, He T, Chang Y, Shi L,Tao S, Yu Z, Brown RE, Wang J: Hippocampal Mechanisms Underlying Impairment inSpatial Learning Long After Establishment of Noise-Induced Hearing Loss in CBAMice. Frontiers in systems neuroscience 2018, 12:35. [4] Liu L, Fang C, Yang J, Zhang H, Huang Y, XuanC, Wang Y, Li S, Sha J, Zha M, Guo M: The effect of noise exposure on insulinsensitivity in mice may be mediated by the JNK/IRS1 pathway. Environmentalhealth and preventive medicine 2018, 23:6. [5] Chen H, Shi L, Liu L, Yin S, Aiken S, Wang J:Noise-induced Cochlear Synaptopathy and Signal Processing Disorders.Neuroscience 2018. [6] Zhang GY, Yang M, Liu B, Huang ZC, Li J, ChenJY, Chen H, Zhang PP, Liu LJ, Wang J, Teng GJ: Changes of the directional brainnetworks related with brain plasticity in patients with long-term unilateralsensorineural hearing loss. Neuroscience 2016, 313:149-61. [7] Song Q, Shen P, Li X, Shi L, Liu L, Wang J, YuZ, Stephen K, Aiken S, Yin S: Coding deficits in hidden hearing loss induced bynoise: the nature and impacts. Scientific reports 2016, 6:25200. [8] Shi LJ, Chang Y, Li XW, Aiken SJ, Liu LJ, WangJ: Coding Deficits in Noise-Induced Hidden Hearing Loss May Stem fromIncomplete Repair of Ribbon Synapses in the Cochlea. Frontiers in neuroscience2016, 10:6. [9] Shi L, Chang Y, Li X, Aiken S, Liu L, Wang J:Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss. Neural plasticity2016, 2016:6143164. [10] Liu LJ, Wang FF, Lu HY, Cao SF, Du ZW, WangYF, Feng X, Gao Y, Zha MM, Guo M, Sun ZL, Wang J: Effects of Noise Exposure onSystemic and Tissue-Level Markers of Glucose Homeostasis and Insulin Resistancein Male Mice. Environ Health Perspect 2016, 124:1390-8. [11] Liu LJ, Shen P, He TT, Chang Y, Shi LJ, Tao S,Li XW, Xun QY, Guo XJ, Yu ZP, Wang J: Noise induced hearing loss impairsspatial learning/memory and hippocampal neurogenesis in mice. Scientificreports 2016, 6:9. [12] Zhang GY, Yang M, Liu B, Huang ZC, Chen H,Zhang PP, Li J, Chen JY, Liu LJ, Wang J, Teng GJ: Changes in the default modenetworks of individuals with long-term unilateral sensorineural hearing loss.Neuroscience 2015, 285:333-42. [13] Shi L, Guo X, Shen P, Liu L, Tao S, Li X, SongQ, Yu Z, Yin S, Wang J: Noise-induced damage to ribbon synapses withoutpermanent threshold shifts in neonatal mice. Neuroscience 2015, 304:368-77. [14] Jie H, Tao S, Liu L, Xia L, Charko A, Yu Z,Bance M, Yin S, Robertson GS, Wang J: Cochlear protection against cisplatin byviral transfection of X-linked inhibitor of apoptosis protein across roundwindow membrane. Gene therapy 2015, 22:546-52. [15] Chen YC, Li X, Liu L, Wang J, Lu CQ, Yang M,Jiao Y, Zang FC, Radziwon K, Chen GD, Sun W, Krishnan Muthaiah VP, Salvi R,Teng GJ: Tinnitus and hyperacusis involve hyperactivity and enhancedconnectivity in auditory-limbic-arousal-cerebellar network. eLife 2015,4:e06576. [16] Liu LJ, Wang FF, Lu HY, Ren XM, Zou JH:Chromanol 293B, an inhibitor of KCNQ1 channels, enhances glucose-stimulatedinsulin secretion and increases glucagon-like peptide-1 level in mice. Islets2014, 6:8. [17] Shi L, Liu L, He T, Guo X, Yu Z, Yin S, WangJ: Ribbon synapse plasticity in the cochleae of Guinea pigs after noise-inducedsilent damage. PloS one 2013, 8:e81566. [18] Liu LJ, Wang H, Shi LJ, Almuklass A, He TT,Aiken S, Bance M, Yin SK, Wang J: Silent Damage of Noise on Cochlear AfferentInnervation in Guinea Pigs and the Impact on Temporal Processing. PloS one2012, 7:11.

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