王大勇 - 东南大学 - 生命科学与技术研究院

个人简介

2001年，毕业于北京大学生命科学学院，获得博士学位。2002年，赴加拿大多伦多大学医学院从事博士后研究工作。2005年，入选东南大学优秀青年教师教学科研资助计划。2007年，入选教育部新世纪优秀人才支持计划。先后获得国家自然科学基金、国家重大科学研究计划项目等资助。研究上主要侧重于从遗传、代谢与环境等不同角度解析神经发育疾病的可能致病机理。为此，主要采用具有丰富神经发育研究背景的经典模式动物秀丽线虫（Caenorhabditis elegans）作为我们的研究体系，并围绕动物抉择与社会性行为的神经环路与分子调控机制开展相关研究工作。

研究领域

1. 动物抉择行为（decision-making）神经环路与分子调控机制 2. 动物社会性行为（social behavior）神经环路与分子调控机制 3. 基于模式动物秀丽线虫的纳米毒理学（nanotoxicology）研究

近期论文

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[1] Mingxia Ren, Li Zhao, Xuecheng Ding,Natalia Krasteva, Qi Rui, Dayong Wang. Developmentalbasis for intestinal barrier against the toxicity of graphene oxide. Particle and Fibre Toxicology, 2018,15: 26. [2] Guosheng Xiao, He Chen, Natalia Krasteva,Qizhan Liu, Dayong Wang.Identification of interneuronsrequired for the aversive response of Caenorhabditiselegans to graphene oxide.J.Nanobiotechnol. 2018, 16: 45. [3] Xuecheng Ding, Qi Rui, Yunli Zhao, HuiminShao, Yiping Yin, Qiuli Wu, Dayong Wang.Toxicity of graphene oxide in nematodes with deficit in epidermal barriercaused by RNA interference knockdown of unc-52.Environ. Sci. Technol. Lett. 2018,doi: 10.1021/acs.estlett.8b00473. [4] Huimin Shao, Zhongyu Han, Natalia Krasteva,Dayong Wang. Identification of signalingcascade in the insulin signaling pathway in response to nanopolystyrene particles. Nanotoxicology 2018, doi: 10.1080/17435390.2018.1530395. [5] Yonglin Yu, Lingtong Zhi, Qiuli Wu, LinaJing, Dayong Wang. NPR-9 regulatesinnate immune response in Caenorhabditiselegans by antagonizing activity of AIB interneurons. Cellular & Molecular Immunology 2018, 15: 27-37. [1] Lingtong Zhi, Man Qu, Mingxia Ren, Li Zhao, YunhuiLi, Dayong Wang. Graphene oxide induces canonical Wnt/β-catenin signaling-dependent toxicityin Caenorhabditis elegans. Carbon, 2017, 113: 122-131. [2] Man Qu, Yunhui Li, Qiuli Wu, Yankai Xia, Dayong Wang. Neuronal ERK signaling in response to graphene oxide innematode Caenorhabditis elegans. Nanotoxicology, 2017, 11(4): 520-533. [3] Mingxia Ren, Li Zhao, Xiao Lv, Dayong Wang. Antimicrobial proteins in the response to graphene oxidein Caenorhabditis elegans. Nanotoxicology, 2017, 11(4): 578-590. [4] Li Zhao, Hanxiao Wan, Qizhan Liu, Dayong Wang.Multi-walled carbon nanotubes-induced alterations in microRNA let-7 and itstargets activate a protection mechanism by conferring a developmental timingcontrol. Particle and Fibre Toxicology, 2017, 14: 27. [5] Lingtong Zhi, Yonglin Yu, Xueying Li, Daoyong Wang, Dayong Wang. Molecular control of innate immune response to Pseudomonas aeruginosa infection by intestinal let-7 in Caenorhabditis elegans. PLoS Pathogens, 2017, 13(1): e1006152.