Pande, Jayanti - University at Albany-SUNY

个人简介

Ph.D., University at Albany, SUNY, 1980

研究领域

Our goal is to determine the molecular mechanisms by which genetic mutations and aging alter the proteins in the human eye and lead to eye diseases such as cataract, glaucoma and macular degeneration. Using a number of biophysical and biochemical methods we investigate how soluble proteins and other molecules form insoluble materials that impede normal function and lead to pathology. We expect our findings to lead to the development of novel therapeutic strategies.

近期论文

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Banerjee, P. R., Puttamadappa, S. S., Pande, A., Shekhtman, A. and Pande, J. (2011) Increased Hydrophobicity and Decreased Backbone Flexibility Explain the Lower Solubility of a Cataract-Linked Mutant of γD-Crystallin. J. Mol. Biol. 412,647-659. (http://www.sciencedirect.com/science/article/pii/S0022283611008369) Ghosh KS, Pande A, Pande J. (2011) Binding of γ-crystallin substrate prevents the binding of copper and zinc ions to the molecular chaperone α-crystallin. Biochemistry. 50, 3279-81. (http://pubs.acs.org/doi/abs/10.1021/bi200091q) Banerjee, P. R., Pande, A., Patrosz, J., Thurston, G. and Pande, J. (2010) Cataract-associated mutant E107A of human gammaD-crystallin shows increased attraction to alpha-crystallin and enhanced light scattering. Proc. Natl. Acad. Sci. U.S.A., 50, 3279-3281.(Cover article, Epub. December 20, 2010), Pande A, Ghosh KS, Banerjee PR, Pande J. (2010)Increase in surface hydrophobicity of the cataract-associated P23T mutant of human gammaD-crystallin is responsible for its dramatically lower, retrograde solubility. Biochemistry, 49, 6122-9. (http://pubs.acs.org/doi/abs/10.1021/bi100664s) Danysh BP, Patel TP, Czymmek KJ, Edwards DA, Wang L, Pande J, Duncan MK.(2010) Characterizing molecular diffusion in the lens capsule. Matrix Biol., 29, 228-36. (http://www.ncbi.nlm.nih.gov/pubmed/20026402) Xie,L., Chou, S.-G., Pande, A., Pande, J., Zhang, J., Dresselhaus, M. S., Kong, J. and Liu, Z. (2010) Single-Walled Carbon Nanotubes Probing the Denaturation of Lysozyme. J. Phys. Chem. C, 114,7717–7720. Pande A, Gillot D, Pande J. (2009) The cataract-associated R14C mutant of human gamma D-crystallin shows a variety of intermolecular disulfide cross-links: a Raman spectroscopic study. Biochemistry, 48, 4937-45. (http://pubs.acs.org/doi/abs/10.1021/bi9004182) Pande A, Zhang J, Banerjee PR, Puttamadappa SS, Shekhtman A, Pande J. (2009) NMR study of the cataract-linked P23T mutant of human gammaD-crystallin shows minor changes in hydrophobic patches that reflect its retrograde solubility. Biochem Biophys Res Commun. 382, 196-9. Wu,Y., Fishkin, N. E., Pande, A., Pande, J. and Sparrow, J. R. (2009)Novel Lipofuscin Bisretinoids Prominent in Human Retina and in a Model of Recessive Stargardt Disease, J. Biol. Chem. 284, 20155-20166. McManus, J., Lomakin, A., Ogun, O., Pande, A., Basan, M., Pande, J. and Benedek,G. B. (2007) "Altered Phase Diagram Due to a Single Point Mutation in Human Gamma-D Crystallin", Proc Natl. Acad. Sci., U.S.A., 104, 16856-61, (Referenced on the cover, Epub. Oct 8, 2007).