张建琼 - 东南大学 - 生命科学与技术研究院

个人简介

1983年毕业于南京铁道医学院医学系获学士学位并留校任教，1999年毕业于南京师范大学生物系获理学博士学位。2001年任教授，主持国家自然基金4项。曾获省部级科技进步二、三、四等奖各1项。被评为铁道部科技拔尖人才、江苏省“青蓝工程”优秀青年骨干教师。多年来，承担《医学免疫学》、《医学微生物学》、《免疫学基础与技术》、《分子生物学》、《病毒学》等专业基础课和专业课的教学，主编和副主编教材3部。2001年赴德国ULM大学高级访问学者。2003年获准建设“发育与疾病相关基因”教育部重点实验室，任副主任；2000年4月至2009年11月任东南大学基础医学院副院长，2009年12月起任东南大学医学院副院长。

研究领域

消化道肿瘤HLA表达异常的分子机制研究乙型肝炎病毒遗传易感性研究 MHC在CNS发育过程中功能及作用机制的研究用于肿瘤诊治的基因工程抗体及肿瘤标志物的研究

近期论文

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Fanyan Meng, Chuanlai Shen, Fengqin Miao Yong He, Yuqing Shen, Wei Xie, Jianqiong Zhang*. A novel one-step strategy for the preparation of HLA/HBc18–27 and HLA/CEA694–702 complexes with ion exchange chromatography. Biotechnol Lett.2010, July (Online). F. Miao, H. Sun, N. Pan, Y. Shen, W. Xie & J. Zhang*. Identification of a novel HLA class I allele, HLA-Cw*0134 in a Chinese individual. Tissue Antigens. 2010, 75(6):737-784. Q. Ye, Y. Shen, X. Wang, J. Yang, F. Miao, C. Shen & J. Zhang*. Hypermethylation of HLA class I gene is associated with HLA class I down-regulation in human gastric cancer. Tissue Antigens. 2010, 75(1):30-39. Qiusha Tang, Jianqiong Zhang, Bing Qi, Chuanlai Shen and Wei Xie*. Downregulation of HLA Class I Molecules in Primary Oral Squamous Cell Carcinomas and Cell Lines. Archives of Medical Research. 2009, 40:256-263. Fanyan Meng, Chuanlai Shen, Yong He, Fengqin Miao, Jianqiong Zhang*. Cloning and expression of three peptide-linked beta 2-microglobulin molecules in Escherichia coli with an isocaudamer technique. Biotechnol Lett. 2009, 31(6):831-836. Shen Y, Xia M, Zhang J, Xu L, Yang J, Chen A, Miao F, Ferrone S, Xie W*. IRF-1 and p65 mediate upregulation of constitutive HLA-A antigen expression by hepatocellular carcinoma cells. Mol Immunol. 2009, 46(10):2045-2053. Y. Yang, J. Zhang, F. Miao1, J. Wei, C. Shen, Y. Shen & W. Xie*. Loss of heterozygosity at 6p21 underlying HLA class I downregulation in Chinese primary esophageal squamous cell carcinomas. Tissue Antigens. 2008, 72: 105-114. W. Jiang, J. Q. Zhang, N. Pan, J. H. Xu & W. Xie*. Identification of a novel HLA-A allele, HLA-A*9216. Tissue Antigens. 2008, 71:478-494. Chuanlai Shen, Ting Hu, Ling Shen, Lei Gao, Wei Xie, Jianqiong Zhang*. Mutations in ISDR of NS5A gene influence interferon efficacy in Chinese patients with chronic hepatitis C virus genotype 1b infection. Journal of Gastroenterology and Hepatology. 2007, 22(11):1898-1903. Yu-Qing Shen, Jian-Qiong Zhang, Mei-Xia, Feng-Qing Miao, Xiang-Nian Shan, Wei Xie*. LMP2/LMP7 Molecules Abnormality Underline the Downregulation of HLA Class I Antigen in a Hepatocellular Carcinoma Cell Line. Journal of Gastroenterology and Hepatology. 2007, 22(7):1155-1161. M. Xia, J. Q. Zhang, Y. Q. Shen, L. H. Xu, A. Q. Chen, F. Q. Miao & W. Xie*. Concordant expression of proto-oncogene promyelocytic leukemia and major histocompatibility antigen HLA class I in human hepatocellular carcinoma. Tissue Antigens. 2007, 70:272-282. Chuanlai Shen, Jianqiong Zhang, Lingzhi Xia, Fanyan Meng, Wei Xie*. Induction of tumor antigen-specific cytotoxic T cell responses in naïve mice by microspheres-based artificial antigen-presenting cell constructs. Cellular Immunology. 2007, 247(1):28-35. Chuanlai Shen*, Chien-Chung Chang, Jianqiong Zhang, Wei Guo, Fanyan Meng, Wei Xie. Structural and functional characterization of peptide-β2m fused HLA-A2/MART127-35 complexes. Biochem Biophys Res Commun. 2006, 342(1):57-65. X.C Wang, J.Q Zhang, Y.Q Shen, F.Q Miao, Wei Xie*. Loss of heterozygosity at 6p21.3 underlying HLA class I downregulation in gastric cancer. J Exp Clin Cancer Res. 2006, 25(9):115-119.