Musah, Rabi - University at Albany-SUNY

个人简介

Associate Professor, Department of Chemistry Director: Center for Achievement, Retention and Student Success (CARSS) Postdoc: The Scripps Research Institute Ph.D.: University of Arkansas, Fayetteville

研究领域

The underlying theme of studies in the Musah research lab is in the mechanisms by which the redox versatility of sulfur is exploited by Nature to solve challenging issues in the chemical biology of plants and some viruses. The development of spectroscopic and mass spectrometric tools and methods that can be used to probe reactions involving organosulfur species are also of interest, as the tracking of organosulfur reaction intermediates presents unique challenges not often encountered with other elements. Our investigations have led to advances in the understanding of: the enzymes involved in the biosynthesis of organosulfur natural products; the importance of organosulfur secondary metabolites in the preservation of plant safety and health; the possible utility of organosulfur natural products as potential drugs, or in agriculture as environmentally benign allelopathic or pest control agents; how sulfur-metal coordination imparts high levels of specificity in protein-nucleic acid binding, as observed in the binding of zinc finger proteins to nucleic acids. We have recently expanded our program to include studies on the impact of plant derived organosulfur compounds on the environment. Additionally, we have discovered that some of the mass spectrometric methods that we have developed for the study of organosulfur chemistry have applications in the examination of plant-based forensics evidence as well as plant metabolome profiling and secondary metabolite biosynthesis. More information on various facets of our work can be found within the subheadings below:

近期论文

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Kasper, S., Samarian, D., Jadhav, A., Rickard, A., Musah, R., Cady, N. (2014), S-Aryl-L-Cysteine Sulfoxides and Related Organosulfur Compounds Alter Oral Biofilm Development and AI-2 Based Cell-Cell Communication. J. Appl. Microbiol., in press. Lesiak, A.D., Cody, R.B., Dane, A.J., and Musah, R.A. (2014), Rapid Detection by Direct Analysis in Real Time-Mass Spectrometry (DART-MS) of Psychoactive Plant Drugs of Abuse: The Case of Mitragyna speciosa aka “Kratom". Forensic Sci. Int., 24: 210-218, doi: 10.1016/j.forsciint.2014.07.005. Musah, R. A., Cody, R.B., Domin, M. A., Lesiak, A.D., Dane, A.J., and Shepard, J. R. E., (2014), DART-MS In-source Collision Induced Dissociation and High Mass Accuracy for New Psychoactive Substance Determinations. Forensic Sci. Int., 244:42-49. Lesiak, A. D., Musah, R. A., Domin, M. A. and Shepard, J. R. E. (2014), DART-MS as a Preliminary Screening Method for “Herbal Incense”: Chemical Analysis of Synthetic Cannabinoids. J. Forensic Sci., 59: 337–343. doi: 10.1111/1556-4029.12354. Lesiak A.D., Musah R.A., Cody R.B., Domin M.A., Dane A.J., Shepard J.R.E., (2013), Direct Analysis in Real Time Mass Spectrometry (DART-MS) of "Bath Salt" Cathinone Drug Mixtures. Analyst, 138:3424-32, doi:10.1039/C3AN00360D. Musah, R. A., Domin, M. A., Cody, R. B., Lesiak, A. D., John Dane, A. and Shepard, J. R. E. (2012), Direct Analysis in Real Time Mass Spectrometry with Collision-Induced Dissociation for Structural Analysis of Synthetic Cannabinoids. Rapid Commun. Mass Spectrom., 26: 2335–2342. doi: 10.1002/rcm.6354 Musah, R. A., Domin, M. A., Walling, M. A. and Shepard, J. R. E. (2012), Rapid Identification of Synthetic Cannabinoids in Herbal Samples via Direct Analysis in Real Time Mass Spectrometry. Rapid Commun. Mass Spectrom., 26: 1109–1114. doi: 10.1002/rcm.6205. Musah R.A., Vuong A.L., Henck C., Shepard J.R., (2012), Detection of the Spermicide Nonoxynol-9 via GC-MS. J Am Soc Mass Spectrom., 23 (5): 996-9. doi: 10.1007/s13361-012-0353-7 Musah R.A., Cody R.B., Dane A.J., Vuong A.L., Shepard J.R., (2012), Direct Analysis in Real Time Mass Spectrometry for Analysis of Sexual Assault Evidence. Rapid Commun Mass Spectrom., 26(9): 1039-46. doi: 10.1002/rcm.6198. Cady, N. C., McKean, K. A., Behnke, J., Kubec, R., Mosier, A. P., Kasper, S. H., & ... Musah, R. A. (2012), Inhibition of Biofilm Formation, Quorum Sensing and Infection in Pseudomonas aeruginosa by Natural Products-Inspired Organosulfur Compounds. Plos ONE, 7 (6): 1-12. doi:10.1371/journal.pone.0038492. He Q., Kubec R., Jadhav A.P., Musah R.A., (2011), First Insights into the Mode of Action of a "Lachrymatory Factor Synthase"--Implications for the Mechanism of Lachrymator Formation in Petiveria alliacea, Allium cepa and Nectaroscordum Species. Phytochemistry, 72(16):1 939-46. doi: 10.1016/j.phytochem.2011.07.013. Kubec R., Cody R.B., Dane A.J., Musah R.A., Schraml J., Vattekkatte A., et al. (2010), Applications of Direct Analysis in Real Time−Mass Spectrometry (DART-MS) in Allium Chemistry. (Z)-Butanethial S-Oxide and 1-Butenyl Thiosulfinates and Their S-(E)-1-Butenylcysteine S-Oxide Precursor from Allium siculum. Journal of Agricultural and Food Chemistry, 58:1121-8, doi: 10.1021/jf903733e. Musah, R. A., He, Q., Kubec, R., Jadhav, A., (2009), Studies of a Novel Cysteine Sulfoxide Lyase from Petiveria alliacea: The First Heteromeric Alliinase. Plant Physiol., 151: 1304-1316. doi: 10.1104/pp.109.142430. Musah, R. A., He, Q., Kubec, R., (2009) Discovery and Characterization of a Novel Lachrymatory Factor Synthase in Petiveria alliacea and Its Influence on Alliinase-Mediated Formation of Biologically Active Organosulfur Compounds. Plant Physiol., 151(3): 1294-1303, doi: 10.1104/pp.109.142539. Kubec, R., Musah, R.A., (2005), γ-Glutamyl dipeptides in Petiveria alliacea. Phytochemistry, 66:2494-2497, doi: 10.1016/j.phytochem.2005.06.029. Kubec, R., Hrbáčová, M., Musah, R. A., Velíšek, J., (2004), Allium Discoloration: Precursors Involved in Onion Pinking and Garlic Greening. J. Agric. Food Chem., 52 (16): 5089-5094, doi: 10.1021/jf0497455 Musah, R. A., (2004), The HIV-1 Nucleocapsid Zinc Finger Protein as a Target of Antiretroviral Therapy. Curr. Top. Med. Chem., 4: 1605-1622, doi: 10.2174/1568026043387331. Kubec, R., Kim, S., Musah, R.A., (2003), The Lachrymatory Principle of Petiveria alliacea. Phytochemistry, 63 (1): 37-40, doi: 10.1016/S0031-9422(02)00759-8. Kubec, R., Velı́šek, J., Musah, Rabi A., (2002), The Amino Acid Precursors and Odor Formation in Society Garlic (Tulbaghia violacea Harv.). Phytochemistry, 60 (1):21-25, doi: 10.1016/S0031-9422(02)00065-1.