马坤岭 - 东南大学

个人简介

英国伦敦大学（UCL）医学博士，教授，博士生导师，副主任医师，东南大学附属中大医院肾科副主任，肾脏病研究所副所长，中华医学会肾脏病专科分会全国青年委员，中国药理学会肾脏病药理学分会全国常务委员，中国病理生理学会肾脏病理生理专委会全国委员，中国生物化学与分子生物学会脂质与脂蛋白专业委员会全国委员，江苏省医学重点人才，江苏省“333工程”培养人选，江苏省“六大人才高峰”培养人选，江苏省优秀硕士生论文指导老师。国家自然科学基金通讯评议专家，教育部学位论文评审专家，科技部项目评审专家库成员，拉萨市专家服务团成员。1997-2000年在东南大学医学院攻读硕士学位，毕业论文被评为江苏省高校第二届优秀硕士论文，以优异成绩毕业留校工作。2003-2004年赴英国伦敦大学学院（UniversityCollege London， UCL）皇家自由医学院肾脏病研究中心做访问学者，2005-2008年再次赴该中心攻读博士学位，读博期间，以第一作者发表SCI收录论文4篇，先后发表在Am J Physiol HeartCirc Physiol、Transplantation、Hepatology（IF=14.079）等国际权威杂志上，因成绩突出，被国家留学基金委授予2007年度优秀留学生奖学金，由驻英大使傅莹亲自颁奖。在顺利获得伦敦大学博士学位后，2009年初被东南大学作为人才引进回国。

研究领域

（1）糖、脂代谢紊乱的基础与临床研究（糖尿病肾病、动脉粥样硬化等）；（2）肾小球疾病分子机制研究；

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Liu J, *Ma KL, Zhang Y, Wu Y, Hu ZB, LvLL, Tang RN, Liu H, Ruan XZ, Liu BC. Activation of mTORC1 disruptedLDL receptor pathway: a potential new mechanism for the progression ofnon-alcoholic fatty liver disease. Int J Biochem Cell Biol. 2015 Jan 23;61C:8-19. doi: 10.1016/j.biocel.2015.01.011. [Epub ahead of print]. (IF=4.24, 通讯作者) 2. *Ma KL, Zhang Y, Liu J, Wu Y, Hu ZB, Ruan XZ, Liu BC.Establishment of an Inflamed Animal Model of Diabetic Nephropathy. Int J Biol Sci 2014; 10(2):149-159.(IF=4.372, 通讯作者) 3. Ma KL,LiuJ, Gao M, Wang CX, Ni J, Zhang Y,Zhang XL, Liu H, Wang YL, Liu BC. Activation of mTORcontributes to foam cell formation in the radial arteries of patients withend-stage renal disease.Clin Nephrol. 2014;81(6)：396-404.（IF=1.232，通讯作者） 4. Ma KL, Ni J, WangCX, Liu J, Zhang Y, Wu Y, Lv LL, Ruan XZ, Liu BC. Interaction of RAS Activationand Lipid Disorders Accelerates the Progression of Glomerulosclerosis. Int J Med Sci 2013;10(12):1615-24. (IF=1.552, 第一作者) 5. Ma KL, Liu J, WangCX, Ni J, Zhang Y, Wu Y, Lv LL, Ruan XZ, Liu BC. Activation of mTOR modulatesSREBP-2 to induce foam cell formation through increased retinoblastoma proteinphosphorylation. CardiovascRes 2013; 100(3):450-60. (IF=5.808, 第一作者). 6. Ni J, *Ma KL, WangCX, Liu J, Zhang Y, Lv LL, Ni HF, Chen YX, Ruan XZ, Liu BC. Activation ofrenin-angiotensin system is involved in dyslipidemia-mediated renal injuries inapolipoprotein E knockout mice and HK-2 cells. Lipids Health Dis 2013; 12(1):49. (IF=2.31, 通讯作者). 7. Ma KL, Liu J, NiJ, Zhang Y, Lv LL, Tang RN, Ni HF, Ruan XZ, Liu BC. Inflammatory stressexacerbates the progression of cardiac fibrosis in high-fat-fed apolipoproteinE knockout mice via endothelial-mesenchymal transition. Int JMed Sci 2013; 10(4):420-6. (IF=1.552, 第一作者). 8. *Ma KL, Wang CX.Analysis of the spectrum and antibiotic resistance of uropathogens in vitro:results based on a retrospective study from a tertiary hospital. Am J Infect Control2013; 41(7):601-6. (IF=2.326, 通讯作者) 9. Liu J, *Ma KL, GaoM, Wang CX, Ni J, Zhang Y, Zhang XL, Liu H, Wang YL, Liu BC. Inflammationdisrupts the LDL receptor pathway and accelerates the progression of vascularcalcification in ESRD patients. PLoS One 2012;7(10):e47217.(IF=3.534, 通讯作者). 10. Ma KL, VargheseZ, Ku Y, Powis SH, Chen Y, Moorhead JF, Ruan XZ. Sirolimus inhibits endogenouscholesterol synthesis induced by inflammatory stress in human vascular smoothmuscle cells. Am J Physiol Heart Circ Physiol 2010; 298(6):H1646-51.(IF=4.012,第一作者). 11.Xu M, Liu D, Ding LH, Ma KL, Wu M, Lv LL, Wen Y, Liu H, Tang RN, Liu BC.FTY720 inhibits tubulointerstitial inflammation in albumin overload-inducednephropathy of rats via the Sphk1 pathway. Acta Pharmacol Sin 2014;35(12):1537-45. (IF=2.496) 12.Liu D, Xu M, Ding LH, Lv LL, Liu H, Ma KL, Zhang AH, Crowley SD, Liu BC.Activation of the Nlrp3 inflammasome by mitochondrial reactive oxygen species:A novel mechanism of albumin-induced tubulointerstitial inflammation. Int JBiochem Cell Biol 2014; 57:7-19. (IF=4.24) 13.Ding LH, Liu D, Xu M, Liu H, Wu M, Tang RN, Lv LL, Ma KL, Liu BC.Enalapril inhibits tubulointerstitial inflammation and NLRP3 inflammasomeexpression in BSA-overload nephropathy of rats. Acta Pharmacol Sin 2014;35(10):1293-301. (IF=2.496) 14.Wu M, Tang RN, Liu H, Ma KL, Lv LL, Liu BC. Nuclear translocation ofβ-catenin mediates the parathyroid hormone-induced ndothelial-to-mesenchymaltransition in human renal glomerular endothelial cells. J Cell Biochem 2014;115(10):1692-701.(IF=3.368). 15. Lv LL, Cao YH, Pan MM, Liu H, Tang RN, Ma KL, Chen PS, Liu BC. CD2AP mRNA in urinary exosome as biomarker of kidneydisease. ClinChim Acta 2014; 428: 26-31. (IF=2.764) 16. Lv LL, CaoY, Liu D, Xu M, Liu H, Tang RN, Ma KL, Liu BC. Isolation andQuantification of MicroRNAs from Urinary Exosomes/Microvesicles for BiomarkerDiscovery. Int J Biol Sci 2013; 9(10):1021-31.(IF=4.372)