陈宝安 - 东南大学

个人简介

陈宝安，男，主任医师，教授，博士（后）导师，全国著名血液病和肿瘤学专家，江苏省科教兴卫工程（血液病）医学重点学科带头人。现任东南大学附属中大医院血液科学科带头人、骨髓增生异常综合征研究所所长、肿瘤学系主任。兼任中国抗癌协会临床肿瘤学协作专业委员会执行委员、江苏省抗癌协会理事、中华医学会江苏省血液学会副主任委员、中华医学会南京血液学会前主任委员。 1979年毕业于南京铁道医学院医疗系（今东南大学医学院），毕业后先后在南京铁道医学院完成硕士，上海医科大学（今复旦大学上海医学院）完成博士学位，在德国乌尔姆大学血液肿瘤科完成博士后研究工作，美国MD Aderson Cancer Center、加州大学伯克利分校、德国海德堡大学等多所世界著名大学高级访问学者。

研究领域

1.肿瘤耐药方面的研究：白血病治疗失败的主要原因之一为多药耐药，在国家自然科学基金资助下，研究发现汉防己甲素是一种非选择性钙离子通道阻滞剂，它能提高化疗药物对白血病细胞的抑制率，且对正常的骨髓细胞无抑制作用。心肌毒副作用低，实验用量临床可以接受；他莫西芬可通过改善膜结构，竟争性抑制膜糖蛋白对化疗药物的转运。二者单独应用均能逆转多药耐药。我们将二者联合应用，发现有明显的协同作用。经专家评定，此方面研究已达到国际先进水平。 2.基因芯片技术的研究：已完成了检测肿瘤微转移的基因芯片的研究，并获得了国家知识产权及发明专利；并进行了蛋白质芯片的研究。 3.阻断肿瘤新生血管的物理原理及生物效应：针对肿瘤血管生成的治疗措施可成为一个新颖抗癌途径。目前此方面的研究主要集中在对肿瘤血管生成因子，和抗内皮细胞增殖和迁移的方面。通过前期研究，发现通过超声空化及空化核的增强效应，直接损伤肿瘤新生血管，并已完成了低功率超声辐射二氧化碳微泡剂致使肿瘤血管栓塞的实验研究。将进一步对动物移植瘤做进一步的研究，并准备进行临床研究，以期建立无创诱导致肿瘤新生血管内皮细胞损伤及阻断肿瘤血液供应的新方法。 4.造血干细胞移植：近年来完成了造血干细胞移植百余例，费用较低，疗效满意，在群过范围内产生了巨大影响。

近期论文

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1.CaiX, Cai X, Wang C, Chen BA*, Hua W, Shen F et al. Antitumor efficacy of DMSA modified Fe3O4 magneticnanoparticles combined with arsenic trioxide and adriamycin in Raji cells. J Biomed Nanotech2014; 10(2): 251-261. 2.ChangH, Wang X, Shiu KK, Zhu Y, Wang J, Li Q, Chen BA* et al. Layer-by-layer assembly of graphene, Au andpoly(toluidine blue O) films sensor for evaluation of oxidative stress of tumorcells elicited by hydrogen peroxide. Biosensors& Bioelectronics 2013; 41: 789-794. 3.ChengJ, Cheng L, Chen BA*, Xia G, Gao C, Song H et al. Effect of magnetic nanoparticles of Fe3O4 and wogonin onthe reversal of multidrug resistance in K562/A02 cell line. Int J Nanomedicine2012; 7: 2843-2852. 4.FangL, Chen BA,Liu S, Wang R, Hu S, Xia G, Chen BA* et al.Synergistic effect of a combination of nanoparticulate Fe3O4 and gambogic acidon phosphatidylinositol 3-kinase/Akt/Bad pathway of LOVO cells. Int JNanomedicine2012; 7: 4109-4118. 5.JiangN, Zhu X, Zhang H, Wang X, Zhou X, Gu J, Chen BA* et al. The relationship between methylenetetrahydrofolatereductase polymorphism and hematological malignancy. Clin Lab2014; 60(5): 767-774. 6.JinN, Malcherek G, Mani J, Zurleit R, Schmitt A, Chen BA et al. Suppression of cytomegalovirus-specific CD8(+)T cells by everolimus. Leuk Lymphoma 2014; 55(5): 1144-1150. 7.LiK, Chen BA*,Xu L, Feng J, Xia G, Cheng J et al.Reversal of multidrug resistance by cisplatin-loaded magnetic Fe3O4nanoparticles in A549/DDP lung cancer cells in vitro and in vivo. Int J Nanomedicine 2013; 8: 1867-1877. 8.LiangG, Li J, Sun B, Li S, Lu L, Wang Y, Chen BA* et al. Deep sequencing reveals complex mechanisms ofmicroRNA deregulation in colorectal cancer. Int J Oncology 2014; 45(2): 603-610. 9.LuX, Zhu A, Cai X, Jia Z, Han W, Ma L, Chen BA* et al. Role of NKG2D in cytokine-induced killer cellsagainst multiple myeloma cells. CancerBio Therapy 2012; 13(8): 623-629. 10.MouY, Hou Y, Chen BA*, Hua Z, Zhang Y, Xie H et al. In vivo migration of dendritic cells labeled with syntheticsuperparamagnetic iron oxide. Int J Nanomedicine 2011; 6: 2633-2640. 11.RenY, Zhang H, Chen BA*, Cheng J, Cai X, Liu R et al. Multifunctional magnetic Fe3O4 nanoparticles combined withchemotherapy and hyperthermia to overcome multidrug resistance. Int J Nanomedicine2012; 7: 2261-2269. 12.SongG, Gu L, Li J, Tang Z, Liu H, Chen BA* et al. Serum microRNAexpression profiling predict response to R-CHOP treatment in diffuse large Bcell lymphoma patients. Ann Hematol 2014.e-pub ahead of print 2014/05/27 13.WangC, Cai X, Chen BA*, He Z, Chen Z, Cen J et al. Up-regulation of tissue inhibitor of metalloproteinase-2promotes SHI-1 cell invasion in nude mice. Leuk Lymphoma 2013; 54(12): 2707-2711. 14.WangC, Zhang H, Chen Y, Shi F, Chen BA*. Gambogic acid-loaded magnetic Fe(3)O(4)nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migrationby inactivating transcription factor ETS1. Int J Nanomedicine2012; 7: 781-787. 15.Wang F, Zhang W, Guo L, Bao W,Jin N, Liu R, Chen BA* et al. Gambogic acid suppresses hypoxia-inducedhypoxia-inducible factor-1alpha /vascular endothelial growth factor expressionvia inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target protein ofrapamycin pathway in multiple myeloma cells. Cancer Sci2014. e-pub ahead of print 2014/06/04. 16.WangL, Zhang H, Chen BA*, Xia G, Wang S, Cheng J et al. Effect of magnetic nanoparticleson apoptosis and cell cycle induced by wogonin in Raji cells. Int J Nanomedicine2012; 7: 789-798. 17.WangX, Wang X, Gao S, Zheng Y, Tang M, ChenBA*. A solid-state electrochemiluminescencesensing platform for detection of catechol based on novel luminescent compositenanofibers. Talanta 2013; 107: 127-132.