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个人简介

1988年毕业于中国医科大学临床医疗本科,1988-1991年在大连医科大学获得药理学硕士学位,留校工作至今。2001年获得生物化学专业博士学位。曾先后在泗川医学奖学金和国家教委留学基金的资助下,赴日本群马大学、美国俄亥俄州立大学作高级访问学者两年。现任大连医科大学药理教研室教授,博士生导师、药学院副院长。多年从事分子药理学的研究。五年来, 共计主持及参加国家及省市各级课题20余项。其中主持国家自然基金3项,国家863子课题1项,国家教育部课题1项,省科技厅项目2项,省教育厅重点实验室项目1项。研究成果申请国家发明专利三项,授权1项。在国内外知名杂志发表论文50余篇SCI收录论文,总影响因子达170。以责任作者发表影响因子5分以上文章7篇。获辽宁省科技进步二等奖2项(排名第二),大连市科技进步一等奖1项(主持人)。

研究领域

(1)急、慢性肝损伤和肝纤维化发生分子机制及药物防治靶点的研究(2)天然化合物对药物代谢酶的作用及其转录调控通路的研究(3) 消化器官缺血再灌注损伤及修复药物防治的分子机制研究。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1.Liu L, Yao J, Li Z, Zu G, Feng D, Li Y, Qasim W, Zhang S, Li T, Zeng H, Tian X.miR-381-3p knockdown improves intestinal epithelial proliferation and barrier function after intestinal ischemia/reperfusion injury by targeting nurr1.Cell Death Dis. 2018 Mar 14;9(3):411. (correspondence author,IF: 5.965) 2. Zhao H, Wang Z, Tang F, Zhao Y, Feng D, Li Y, Hu Y, Wang C, Zhou J, Tian X, Yao J.Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis.Pharmacol Res. 2018 Feb;128:327-337.(correspondence author,IF: 4.480) 3. Li Z, Wang G, Feng D, Zu G, Li Y, Shi X, Zhao Y, Jing H, Ning S, Le W, Yao J, Tian X.Targeting the miR-665-3p-ATG4B-autophagy axis relieves inflammation and apoptosis in intestinal ischemia/reperfusion.Cell Death Dis. 2018 May 1;9(5):483.(correspondence author,IF: 5.965) 4.Zhang S, Wang Z, Zhu J, Xu T, Zhao Y, Zhao H, Tang F, Li Z, Zhou J, Gao D, Tian X, Yao J.Carnosic Acid Alleviates BDL-Induced Liver Fibrosis through miR-29b-3p-Mediated Inhibition of the High-Mobility Group Box 1/Toll-Like Receptor 4 Signaling Pathway in Rats. Front Pharmacol. 2018 Jan 19;8:976.(correspondence author,IF:4.400) 5.Shi X, Zhao Y, Ding C, Wang Z, Ji A, Li Z, Feng D, Li Y, Gao D, Zhou J, Tian X, Yao J.Salvianolic acid A alleviates chronic ethanol-induced liver injury via promotion of β-catenin nuclear accumulation by restoring SIRT1 in rats.Toxicol Appl Pharmacol. 2018 Jul 1;350:21-31.(correspondence author,IF:3.791) 6. Zhao Y, Shi X, Ding C, Feng D, Li Y, Hu Y, Wang L, Gao D, Tian X, Yao J.Carnosic acid prevents COL1A2 transcription through the reduction of Smad3 acetylation via the AMPK alpha 1/SIRT1 pathway.Toxicol Appl Pharmacol. 2018 Jan 15;339:172-180.(correspondence author,IF:3.791) 7.Zhang N, Hu Y, Ding C, Zeng W, Shan W, Fan H, Zhao Y, Shi X, Gao L, Xu T, Wang R, Gao D, Yao J.Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats.Toxicol Lett. 2017 Feb 5;267:1-10.(correspondence author,IF:3.858) 8.P66shc promotes epithelial-to-mesenchymal transition in hepatic fibrosis.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY .2016 ; 31 : 398 - 398(IF:3.452)(SCI) 9.Shan W, Gao L, Zeng W, Hu Y, Wang G, Li M, Zhou J, Ma X, Tian X, Yao J.Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease.Cell Death Dis. 2015 Jul 23;6:e1833..(correspondence author,IF:5.378) 10.Wang G, Yao J, Li Z, Zu G, Feng D, Shan W, Li Y, Hu Y, Zhao Y, Tian X.miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling.Antioxid Redox Signal. 2016 Jun 10;24(17):961-73..(IF:6.337) 11.Gao L, Shan W, Zeng W, Hu Y, Wang G, Tian X, Zhang N, Shi X, Zhao Y, Ding C, Zhang F, Liu K, Yao J.Carnosic acid alleviates chronic alcoholic liver injury by regulating the SIRT1/ChREBP and SIRT1/p66shc pathways in rats.Mol Nutr Food Res. 2016 Sep;60(9):1902-11.(correspondence author,IF:4.323) 12.Ding C, Zhao Y, Shi X, Zhang N, Zu G, Li Z, Zhou J, Gao D, Lv L, Tian X, Yao J.New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.Sci Rep. 2016 Jun 27;6:28734.(correspondence author,IF:4.259) 13.Zeng W, Shan W, Gao L, Gao D, Hu Y, Wang G, Zhang N, Li Z, Tian X, Xu W, Peng J, Ma X, Yao J.Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease.Sci Rep. 2015 Nov 3;5:16013. (correspondence author,IF:5.228) 14.Fan Z, Yao J, Li Y, Hu X, Shao H, Tian X.Anti-inflammatory and antioxidant effects of curcumin on acute lung injury in a rodent model of intestinal ischemia reperfusion by inhibiting the pathway of NF-Kb.Int J Clin Exp Pathol. 2015 Apr 1;8(4):3451-9.(correspondence author,IF:1.706) 15.Hu Y, Zhang N, Fan Q, Lin M, Zhang C, Fan G, Zhai X, Zhang F, Chen Z, Yao J.Protective efficacy of carnosic acid against hydrogen peroxide induced oxidative injury in HepG2 cells through the SIRT1 pathway.Can J Physiol Pharmacol. 2015 Aug;93(8):625-31.(correspondence author,IF:1.822) 16. Lin M, Zhai X, Wang G, Tian X, Gao D, Shi L, Wu H, Fan Q, Peng J, Liu K, Yao J.Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways.J Pharmacol Sci. 2015 Feb;127(2):203-10.(correspondence author,IF:2.415) 17. 17.Yan H, Jihong Y, Feng Z, Xiaomei X, Xiaohan Z, Guangzhi W, Zhenhai M, Dongyan G, Xiaochi M, Qing F, Kexin L, Xiaofeng T.Sirtuin 1-Mediated Inhibition of p66shc Expression Alleviates Liver Ischemia/Reperfusion Injury.Crit Care Med. 2014 May;42(5):e373-81.(correspondence author,IF:6.312) 18.Wang G, Chen Z, Zhang F, Jing H, Xu W, Ning S, Li Z, Liu K, Yao J, Tian X.Blockade of PKC beta protects against remote organ injury induced by intestinal ischemia and reperfusion via a p66shc-mediated mitochondrial apoptotic pathway.Apoptosis. 2014 Sep;19(9):1342-53.(correspondence author,IF:3.833)

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