个人简介

B.A. Harvard College (1994) Research Fellow, Johannes Gutenberg Universitaet, Mainz, DE (1994-1995) Ph.D. California Institute of Technology (2000) Caltech Herbert Newby McCoy Award (2000) Helen Hay Whitney Postdoctoral Fellow, Biophysics, Caltech (2000-2002) Camille and Henry Dreyfus New Faculty Award (2003) National Science Foundation CAREER Award (2005) Camille and Henry Dreyfus Teacher-Scholar Award (2007)

研究领域

Biological/Chemical Biology/Chemical Physics and Physical Chemistry/Inorganic/Materials Chemistry

Our lab is developing chemical and biophysical tools to study and manipulate complex biological systems. Projects span many areas of synthetic organic, inorganic, and biophysical chemistry; molecular, cell, and developmental biology; and bioengineering. We are particularly interested in developing new technologies for biomolecular imaging and the fabrication of functional bio-nanomaterials

近期论文

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Ruble, B. K.; Richards, J. L.; Cheung-Lau, J. C.; Dmochowski, I. J., Mismatch discrimination and efficient photomodulation with split 10-23 DNAzymes. Inorganica Chimica Acta 2012, 380 (1), 386-391. http://dx.doi.org/10.1016/j.ica.2011.10.068 Liao, Z.; Lampe, J. W.; Ayyaswamy, P. S.; Eckmann, D. M.; Dmochowski, I. J., Protein assembly at the air-water interface studied by fluorescence microscopy. Langmuir 2011, 27 (21), 12775-12781. http://dx.doi.org/10.1021/la203053g Kamat, N. P.; Liao, Z.; Moses, L. E.; Rawson, J.; Therien, M. J.; Dmochowski, I. J.; Hamme, D. A., Sensing membrane stress with near IR-emissive porphyrins. Proceedings of the National Academy of Sciences of the United States of America 2011, 108 (34), 13984-13989. http://dx.doi.org/10.1073/pnas.1102125108 Jacobson, D. R.; Khan, N. S.; Colle, R.; Fitzgerald, R.; Laureano-Perez, L.; Bai, Y.; Dmochowski, I. J., Measurement of radon and xenon binding to a cryptophane molecular host. Proceedings of the National Academy of Sciences of the United States of America 2011, 108 (27), 10969-10973. http://dx.doi.org/10.1073/pnas.1105227108 Seward, G. K.; Bai, Y.; Khan, N. S.; Dmochowski, I. J., Cell-compatible, integrin-targeted cryptophane- 129Xe NMR biosensors. Chemical Science 2011, 2 (6), 1103-1110. http://dx.doi.org/10.1039/c1sc00041a Taratula, O.; Hill, P. A.; Bai, Y.; Khan, N. S.; Dmochowski, I. J., Shorter synthesis of trifunctionalized cryptophane - A derivatives. Organic Letters 2011, 13 (6), 1414-1417. http://dx.doi.org/10.1021/ol200088f Khan, N. S.; Perez-Aguilar, J. M.; Kaufmann, T.; Hill, P. A.; Taratula, O.; Lee, O. S.; Carroll, P. J.; Saven, J. G.; Dmochowski, I. J., Multiple hindered rotators in a gyroscope-inspired tribenzylamine hemicryptophane. Journal of Organic Chemistry 2011, 76 (5), 1418-1424. http://dx.doi.org/10.1021/jo102480s Taratula, O.; Hill, P. A.; Khan, N. S.; Carroll, P. J.; Dmochowski, I. J., Crystallographic observation of 'induced fit' in a cryptophane host-guest model system. Nature Communications 2010, 1 (9). http://dx.doi.org/10.1038/ncomms1151 Kamat, N. P.; Robbins, G. P.; Rawson, J.; Therien, M. J.; Dmochowski, I. J.; Hammer, D. A., A generalized system for photoresponsive membrane rupture in polymersomes. Advanced Functional Materials 2010, 20 (16), 2588-2596. http://dx.doi/org/10.1002/adfm.201000659 Lampe, J. W.; Liao, Z.; Dmochowski, I. J.; Ayyaswamy, P. S.; Eckmann, D. M., Imaging macromolecular interactions at an interface. Langmuir 2010, 26 (4), 2452-2459. http://dx.doi.org/10.1021/la903703u Richards, J. L.; Seward, G. K.; Wang, Y. H.; Dmochowski, I. J., Turning the 10-23 DNAzyme on and off with light. ChemBioChem 2010, 11 (3), 320-324. http://dx.doi.org/10.1002/cbic.200900702 Taratula, O.; Dmochowski, I. J., Functionalized 129Xe contrast agents for magnetic resonance imaging. Current Opinion in Chemical Biology 2010, 14 (1), 97-104. http://dx.doi.org/10.1016/j.cbpa.2009.10.009 Dmochowski, I., Xenon out of its shell. Nature chemistry 2009, 1 (3), 250. http://dx.doi.org/10.1038/nchem.230 Swift, J.; Butts, C. A.; Cheung-Lau, J.; Yerubandi, V.; Dmochowski, I. J., Efficient Self-Assembly of Archaeoglobus fulgidus ferritin around metallic cores. Langmuir 2009, 25 (9), 5219-5225. http://dx.doi.org/10.1021/la8040743 Butts, C. A.; Xi, J.; Brannigan, G.; Saad, A. A.; Venkatachalan, S. P.; Pearce, R. A.; Klein, M. L.; Eckenhoff, R. G.; Dmochowski, I. J., Identification of a fluorescent general anesthetic, 1-aminoanthracene. Proceedings of the National Academy of Sciences of the United States of America 2009, 106 (16), 6501-6506. http://dx.doi.org/10.1073/pnas.0810590106 Robbins, G. P.; Jimbo, M.; Swift, J.; Therien, M. J.; Hammer, D. A.; Dmochowski, I. J., Photoinitiated destruction of composite Porphyrin-Protein polymersomes. Journal of the American Chemical Society 2009, 131 (11), 3872-3874. http://dx.doi.org/10.1021/ja808586q Aru Hill, P.; Wei, Q.; Troxler, T.; Dmochowski, I. J., Substituent effects on xenon binding affinity and solution behaviour of water-soluble cryptophanes. Journal of the American Chemical Society 2009, 131 (8), 3069-3077. http://dx.doi.org/10.1021/ja8100566 Chambers, J. M.; Hill, P. A.; Aaron, J. A.; Han, Z.; Christiansen, D. W.; Kuzma, N. N.; Dmochowski, I. J., Cryptophane xenon-129 nuclear magnetic resonance biosensors targeting human carbonic anhydrase. Journal of the American Chemical Society 2009, 131 (2), 563-569. http://dx.doi.org/10.1021/ja806092w Butts, C. A.; Swift, J.; Kang, S. G.; Di Costanzo, L.; Christiansen, D. W.; Saven, J. G.; Dmochowski, I. J., Directing noble metal ion chemistry within a designed ferritin protein. Biochemistry 2008, 47 (48), 12729-12739. http://dx.doi.org/10.1021/bi8016735 Richards, J. L.; Tang, X.; Turetsky, A.; Dmochowski, I. J., RNA bandages for photoregulating in vitro protein synthesis. Bioorganic and Medicinal Chemistry Letters 2008, 18 (23), 6255-6258. http://dx.doi.org/10.1016/j.bmcl.2008.09.093