研究领域

analytical chemistry biomolecules proteins and peptides instrumentation laser-based detectors

Professor Waldron’s group uses capillary electrophoresis with laser-based detection and mass spectrometry to identify proteins and peptides of biological importance. The group develops enzyme microreactors and methods for micro-scale sample preparation and separation for applications in environmental and biomolecule analyses.

近期论文

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N. Kaur, J-L. Cabral, A. Morin and K.C. Waldron*, "Headspace Stir Bar Sorptive Extraction–GC/MS Characterization of the Diluted Vapor Phase of Cigarette Smoke Delivered to an In Vitro Cell Exposure Chamber", J. Chromatography A, 1218, 2011, 324-333. (DOI: 10.1016/j.chroma.2010.11.035). N. Kaur, M. Lacasse, J-P. Roy, J-L. Cabral, J. Adamson, G. Errington, K.C. Waldron, M. Gaça and A. Morin*, "Evaluation of Precision and Accuracy of the Borgwaldt RM20S® Smoking Machine Designed for In Vitro Exposure", Inhalation Toxicology, 22(14), 2010, 1174-1183. C. Dartiguenave, H. Hamad and K.C. Waldron*, “Immobilization of Trypsin onto 1,4 Diisothiocyanatobenzene-Activated Porous Glass for Microreactor–Based Peptide Mapping by Capillary Electrophoresis: Effect of Calcium Ions on the Immobilization Procedure”, Analytica Chimica Acta, 663(2), 2010, 198-205. (DOI: 10.1016/j.aca.2010.01.042) G. Roman-Gusetu, K.C. Waldron* and D. Rochefort, “Development of an enzymatic microreactor based on microencapsulated laccase with off-line capillary electrophoresis for measurement of oxidation reactions”, Journal of Chromatography A, 1216, 2009, 8270-8276. N. Kaur, M. Lacasse, A. Fürtös, K.C. Waldron* and A. Morin*, “Sequential fractionation with concurrent chemical and toxicological characterization of the combustion products of chlorogenic acid”, Journal of Chromatography A, 1216, 2009, 4703-4712. I. Migneault, C. Dartiguenave, J. Vinh, M.J. Bertrand and K.C. Waldron*, “Two Glutaraldehyde-Immobilized Trypsin Preparations for Peptide Mapping by Capillary Zone Electrophoresis, Liquid Chromatography and Mass Spectrometry”, Journal of Liquid Chromatography and Related Techniques, 31, 2008, 789-806. M. Elsabahy, M. Zhang, S-M. Gan, K.C. Waldron and J-C. Leroux*, “Synthesis and Enzymatic Stability of PEGylated Oligonucleotide Duplexes and their Self-assemblies with Polyamidoamine Dendrimers”, Soft Matter, 4, 2008, 294-302. Funding: M. Schirm, I. Schoenhofen, S.M. Logan, K.C. Waldron and P. Thibault*, “Identification of Unusual Bacterial Glycosylation by Tandem Mass Spectrometry Analyses of Intact Proteins" Analytical Chemistry, 77(23), 2005, 7774-7782. M-E. Beaudoin, J. Gauthier, I. Boucher and K.C. Waldron* “Capillary Electrophoresis Separation of a mixture of Chitin and Chitosan Oligosaccharides Derivatized using a Modified Fluorophore Conjugation Procedure” Journal of Separation Science, 12, 2005, 1390-1398. M. Walles, Y. Gu, C. Dartiguenave , F. M. Musteata, K. Waldron, D. Lubda, J. Pawliszyn*, “Approaches for Coupling Solid-Phase Microexraction to Nanospray”, Journal of Chromatography A, 1067(1-2), 2005, 197-205. I. Migneault, C. Dartiguenave, M.J. Bertrand and K.C. Waldron*, “Glutaraldehyde: Behavior in Aqueous Solution, Reaction with Proteins, and Application to Enzyme Crosslinking (Review Article)”, BioTechniques, 37(5), 2004, 790-796, 798-802. I. Migneault, C. Dartiguenave, J. Vinh, M.J. Bertrand and K.C. Waldron*, “Comparison of two glutaraldehyde immobilization techniques for solid-phase tryptic peptide mapping of human hemoglobin by capillary zone electrophoresis and mass spectrometry”, Electrophoresis, 25, 2004, 1367-1378. M. Aouffen, J. Paquin, A. Fürtös, K.C. Waldron and M-A. Mateescu, “Oxidative Aggregation of Ceruloplasmin Induced by Hydrogen Peroxide is Prevented by Pyruvate” Free Radical Research, 38(1), 2004, 19-26. C. Hémond, A. Fürtös-Matei and K.C. Waldron*, “A Comparison between Electrokinetic Capillary Chromatography and Absorption Spectroscopy for the Analysis of Peptide-Micelle Association by Weak Hydrophobic Interactions”, Electrophoresis, 24(5), 2003, 816-823. I. Migneault, C. Dartiguenave, H. Hamad, K.C. Waldron*, M.J. Bertrand and J. Vinh, “Comparison of Trypsin Immobilization Techniques With and Without a Solid Support for Peptide Mapping”, ASMS-2003 (Proceedings of the 51st Annual Conference on Mass Spectrometry and Allied Topics, Montréal, Canada, June 8-12, 2003). J-L. Cabral, K.C. Waldron* and F. Monette, “Analysis of Total Phosphorous in Wastewater by Microwave Digestion-Capillary Electrophoresis with Indirect UV Detection”, in “EnviroAnalysis 2002 (Proceedings of the 4th Biennial International Conference on Monitoring and Measurement of the Environment, Toronto, Canada, May 27-30, 2002)”, Clement, R. and Burk, B. (Eds.), pp. 473-478. A. Fürtös-Matei, S.A. St-Pierre and K.C. Waldron*, “Capillary Electrophoresis Separation of Endogenous N-truncated Neuropeptide Y Fragments”, International Journal of Biochromatography 6(3), 2001, 219-230. É. Bonneil and K.C. Waldron*, “On-line System for Peptide Mapping by Capillary Electrophoresis at Submicromolar Concentrations”, Talanta 53(3), 2000, 687-699. A. Fürtös-Matei , R. Day, S.A. St-Pierre, L.G. St-Pierre and K.C. Waldron*, “Micellar Electrokinetic Chromatography Separations of Dynorphin Peptide Analogs” Electrophoresis, 21(4), 2000, 715-723. É. Bonneil, M. Mercier and K.C. Waldron*, “Reproducibility of a Solid-Phase Trypsin Microreactor for Peptide Mapping by Capillary Electrophoresis” Analytica Chimica Acta, 404, 2000, 29-45.