研究领域

bioanalytical chemistry mass spectrometry proteins protein modifications cell signaling

Professor Thibault’s research is primarily focused on the development and application of new technologies in proteomics and bioanalytical mass spectrometry to the identification of proteins and their post-translational modifications. In multidisciplinary research, these tools provide a deeper understanding of molecular mechanisms and post-translational modifications, which regulate the function and translocation of proteins involved in immunity and signaling of cancer cells.

近期论文

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E4F1 Is a Master Regulator of CHK1-Mediated Functions.Grote D, Moison C, Duhamel S, Chagraoui J, Girard S, Yang J, Mayotte N, Coulombe Y, Masson JY, Brown GW, Meloche S, Sauvageau .Cell Rep 2015-03-31. Investigating the Regulation of Stem and Progenitor Cell Mitotic Progression by In Situ Imaging.Gerhold AR, Ryan J, Vallée-Trudeau JN, Dorn JF, Labbé JC, Maddox P.Curr. Biol. 2015-03-25. Molecular Pathways: GLI1-Induced Drug Glucuronidation in Resistant Cancer Cells.Zahreddine HA, Borden K.Clin. Cancer Res. 2015-03-25. Effect of the transient pharmacological inhibition of mapk3/1 pathway on ovulation in mice.Siddappa D, Beaulieu É, Gévry N, Roux PP, Bordignon V, Duggavathi .PLoS ONE 2015-03-24;10(3):e0119387. The Perlecan Fragment LG3 Regulates Homing of Mesenchymal Stem Cells and Neointima Formation During Vascular Rejection.Pilon EA, Dieudé M, Qi S, Hamelin K, Pomerleau L, Beillevaire D, Durocher Y, Zutter M, Coutu D, Perreault C, Hébert M.Am. J. Transplant. 2015-03-23. Interplay Between Histone H3 Lysine 56 Deacetylation and Chromatin Modifiers in Response to DNA Damage.Simoneau A, Delgoshaie N, Celic I, Dai J, Abshiru N, Costantino S, Thibault P, Boeke JD, Verreault A, Wurtele .Genetics 2015-03-18. The expanding role of mTOR in cancer cell growth and proliferation.Cargnello M, Tcherkezian J, Roux P.Mutagenesis 2015-03-01;30(2):169-176. Defective repair of uracil causes telomere defects in mouse hematopoietic cells.Vallabhaneni H, Zhou F, Maul RW, Sarkar J, Yin J, Lei M, Harrington L, Gearhart PJ, Liu .J. Biol. Chem. 2015-02-27;290(9):5502-11. A Cell-Signaling Network Temporally Resolves Specific versus Promiscuous Phosphorylation.Kanshin E, Bergeron-Sandoval LP, Isik SS, Thibault P, Michnick S.Cell Rep 2015-02-24;10(7):1202-14. Haploinsufficiency screen highlights two distinct groups of ribosomal protein genes essential for embryonic stem cell fate.Fortier S, MacRae T, Bilodeau M, Sargeant T, Sauvageau .Proc. Natl. Acad. Sci. U.S.A. 2015-02-17;112(7):2127-32. A high-sensitivity phospho-switch triggered by Cdk1 governs chromosome morphogenesis during cell division.Robellet X, Thattikota Y, Wang F, Wee TL, Pascariu M, Shankar S, Bonneil É, Brown CM, D'Amours .Genes Dev. 2015-02-15;29(4):426-39. Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing.Castonguay E, White SA, Kagansky A, St-Cyr DJ, Castillo AG, Brugger C, White R, Bonilla C, Spitzer M, Earnshaw WC, Schalch T, Ekwall K, Tyers M, Allshire R.Mol. Cell. Biol. 2015-02-15;35(4):662-74. CDK-1 and Two B-Type Cyclins Promote PAR-6 Stabilization during Polarization of the Early C. elegans Embryo.Rabilotta A, Desrosiers M, Labbé J.PLoS ONE 2015-02-06;10(2):e0117656. The BioGRID interaction database: 2015 update.Chatr-Aryamontri A, Breitkreutz BJ, Oughtred R, Boucher L, Heinicke S, Chen D, Stark C, Breitkreutz A, Kolas N, O'Donnell L, Reguly T, Nixon J, Ramage L, Winter A, Sellam A, Chang C, Hirschman J, Theesfeld C, Rust J, Livstone MS, Dolinski K, Tyers .Nucleic Acids Res. 2015-01-28;43(Database issue):D470-8. Understanding the Polo Kinase machine.Archambault V, Lépine G, Kachaner .Oncogene 2015-01-26. Sentinel Node Biopsy After Neoadjuvant Chemotherapy in Biopsy-Proven Node-Positive Breast Cancer: The SN FNAC Study.Boileau JF, Poirier B, Basik M, Holloway CM, Gaboury L, Sideris L, Meterissian S, Arnaout A, Brackstone M, McCready DR, Karp SE, Trop I, Lisbona A, Wright FC, Younan RJ, Provencher L, Patocskai E, Omeroglu A, Robidoux .J. Clin. Oncol. 2015-01-20;33(3):258-64. CDC28 phosphorylates Cac1p and regulates the association of chromatin assembly factor i with chromatin.Jeffery DC, Kakusho N, You Z, Gharib M, Wyse B, Drury E, Weinreich M, Thibault P, Verreault A, Masai H, Yankulov .Cell Cycle 2015-01-02;14(1):74-85. In Vitro and In Vivo Characterization of the Rab11-GAP Activity of Drosophila Evi5.Laflamme C, Emery .Methods Mol. Biol. 2015-01-01;1298:187-94. The eukaryotic translation initiation factor eIF4E in the nucleus: taking the road less traveled.Osborne MJ, Borden K.Immunol. Rev. 2015-01-01;263(1):210-23. Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.Thevakumaran N, Lavoie H, Critton DA, Tebben A, Marinier A, Sicheri F, Therrien .Nat. Struct. Mol. Biol. 2015-01-01;22(1):37-43.