李颖博 - 北京大学

个人简介

2001.09 – 2005.07 北京大学医学部，药学专业，本科 2005.09 – 2007.07 北京大学医学部，药理专业，硕士 2007.09 – 2011.08 澳门大学，生物医药专业，博士 2011.11 – 今，北京大学医学部，天然药物及仿生药物国家重点实验室

研究领域

1. 肿瘤耐受相关基因及调节机制 2. 抗肿瘤药物筛选及作用机制的研究

近期论文

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Li Y, Wang J, Gao X, Han W, Zheng Y, Xu H, Zhang C, He Q, Zhang L, Zhou D. c-Met targeting enhances the effect of irradiation and chemical agents against malignant colon cells harboring a KRAS mutation. PlosOne. 2014,9(11):e113186. Li YB, Wang ZQ, Yan X, Chen MW, Bao JL, Wu GS, Ge ZM, Zhou DM, Wang YT, Li RT. IC-4, a new irreversible EGFR inhibitor, exhibits prominent anti-tumor and anti-angiogenesis activities. Cancer Lett. 2013, 28: 340(1):88-96. Li YB, Zhong ZF, Chen MW, Bao JL, Wu GS, Zhang QW, Lee SM, Hoi PM, Wang YT. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evid Based Complement Alternat Med. 2013:851714. Li YB, Gao JL, Zhong ZF, Hoi PM, Lee SM, Wang YT. Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways. Pharmacol Rep. 2013, 65(3):700-9. Li YB, Gao JL, Lee SM, Zhang QW, Hoi PM, Wang YT. Bisdemethoxycurcumin protects endothelial cells against t-BHP-induced cell damage by regulating the phosphorylation level of ERK1/2 and Akt. Int J Mol Med. 2011, 27(2):205-11. Li YB, Lin ZQ, Zhang ZJ, Wang MW, Zhang H, Zhang QW, Lee SM, Wang YT, Hoi PM. Protective, Antioxidative and Antiapoptotic Effects of 2-Methoxy-6-Acetyl-7-Methyljuglone from Polygonum cuspidatum in PC12 Cells. Planta Med. 2011, 77(4):354-61. Zhang J1, Li Y1, Fang X, Zhou D, Wang Y, Chen M. TPGS-g-PLGA/Pluronic F68 mixed micelles for tanshinone IIA delivery in cancer therapy. Int J Pharm. 2014, 476(1-2):185-198. Wang J, Li Y, Patel NG, Zhang G, Zhou D, Pang Y. A single molecular probe for multi-analyte (Cr³⁺, Al³⁺ and Fe³⁺) detection in aqueous medium and its biological application. Chem Commun (Camb). 2014, 50(82):12258-61. Zhang J, Li Y, Gao W, Repka MA, Wang Y, Chen M. Andrographolide-loaded PLGA-PEG-PLGA micelles to improve its bioavailability and anticancer efficacy. Expert Opin Drug Deliv. 2014, 11(9):1367-80. Wang JF, Li YB, Duah E, Paruchuri S, Zhou DM, Pang Y. A Selective NIR-Emitting Zinc Sensor by Using Schiff Base Binding to Turn-On Excited-State Intramolecular Proton Transfer. Journal of Materials Chemistry B. 2014, 2, 2008. Zhong ZF, Li YB, Wang SP, Tan W, Chen XP, Chen MW, Wang YT. Furanodiene enhances tamoxifen-induced growth inhibitory activity of ERa-positive breast cancer cells in a PPARγ independent manner. J Cell Biochem. 2012, 113(8):2643-51. Tan W, Li YB, Chen MW, Wang YT. Berberine Hydrochloride: Anticancer Activity and its Nanoparticulate Delivery Systems. Int J nanomed 2011, 6:1773-713. Gao JL, He TC, Li YB, Wang YT. A traditional Chinese medicine formulation consisting of Rhizoma Corydalis and Rhizoma Curcumae exerts synergistic anti-tumor activity. Oncol Rep. 2009, 22(5):1077-83. Li YB, Wang R, Wu HL, et al. Serum amyloid A mediates the inhibitory effect of Ganoderma lucidum polysaccharides on tumor cell adhesion to endothelial cells. Oncol Rep. 2008, 20(3):549-56. Li YB, Li YH, et al. Effect of Ganoderma lucidum polysaccharides (GlPS) on tumor-endothelium interactions, Chinese Pharmacological Bulletin, 2008, 24(2):250-3. Wang R, Li YB, Li YH, et al. Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB. Brain Res. 2008, 1210:84-91.