熊德彩 - 北京大学

个人简介

2001.8-2005.7 理学学士，兰州大学化学化工学院化学基地班 2005.8-2010.7 理学博士，北京大学药学院化学生物学系，导师：叶新山教授 2010.8-至今助理研究员、副研究员、研究员、博士生导师，北京大学药学院、天然药物及仿生药物国家重点实验室

研究领域

光/电驱动的糖化学反应研究糖基化新方法和新策略生物活性寡(聚)糖和糖模拟物的合成及活性评价

近期论文

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1. Kai-Meng Liu, Peng-Yu Wang, Zhen-Yan Guo, De-Cai Xiong*, Xian-Jin Qin, Miao Liu, Meng Liu, Wan-Ying Xue, and Xin-Shan Ye*, “Iterative Synthesis of 2-Deoxyoligosaccharides Enabled by Stereoselective Photoredox-catalyzed Glycosylation”, Angew. Chem. Int. Ed., 2022, 61, e202114726. 2. Xia Wu, Biao Wu, Chen-Fei Gao, Xin-Shan Ye, De-Cai Xiong*, “Additive-controlled synthesis of 1- and 2-deoxysugars from thioglycosides”, J. Carbohydr. Chem., 2021, 40(7-9), 479-500. 3. Yafei Cao+, Minmin Zhou+, Run-Ze Mao, You Zou, Feng Xia, Da-Ke Liu, Jianhui Liu, Qin Li, De-Cai Xiong*, Xin-Shan Ye*, “Visible-light-promoted 3,5-dimethoxyphenyl glycoside activation and glycosylation”, Chem. Commun., 2021, 57, 10899-10902. 4. Miao Liu, Zhao-Xiang Luo, Tian Li, De-Cai Xiong*, Xin-Shan Ye*, “Electrochemical Trifluoromethylation of Glycals”, J. Org. Chem., 2021, 86(22), 16187-16194. 5. Zhao-Xiang Luo+, Miao Liu+, Tian Li, De-Cai Xiong*, Xin-Shan Ye*, “Electrochemical Bromination of Glycals”, Front. Chem., 2021, 9, 796690. 6. Miao Liu, Kai-Meng Liu, De-Cai Xiong,* Hanyu Zhang, Tian Li, Bo-Han Li, Xianjin Qin, Jinhe Bai, Xin-Shan Ye,* “Stereoselective Electro-2-Deoxyglycosylation from Glycals”, Angew. Chem. Int. Ed., 2020, 59, 15204-15208. 7. Miao Liu, Bo-Han Li, Tian Li, Xia Wu, Meng Liu, De-Cai Xiong,* Xin-Shan Ye,* "C-Glycosylation enabled by N-(glycosyloxy)acetamides”, Org. Biomol. Chem. 2020, 18, 3043-3046. 8. Bo-Han Li, Wenlong Yao, Hong Yang, Congying Wu, De-Cai Xiong,* Yuxin Yin,* Xin-Shan Ye*, "Total synthesis of tumor-associated KH-1 antigen core nonasaccharide via photo-induced glycosylation”, Org. Chem. Front., 2020, 7, 1255–1259. 9. Zhen-Yan Guo, Jin-He Bai, Miao Liu, De-Cai Xiong*, Xin-Shan Ye*, “Advances in the Synthesis of C-Glycosides from Glycals”. Chin. J. Org. Chem., 2020, 40, 3094-3111. 10. Wanjun Yan, Wenming Li, De-Cai Xiong*, Xin-Shan Ye*, “Design, synthesis and evaluation of carbamate-containing sialyltransferase inhibitors”, J. Chin. Pharm. Sci. 2020, 29(1), 29-44. 11. Li Gefei, De-Cai Xiong*, Xin-Shan Ye, “Recent Progress and Development Trend of Synthetic Carbohydrate Vaccines”, Prog. Pharm. Sci. 2020, 44(7), 303-311. 12. Hanyu Zhang, Meng Liu, Xia Wu, Miao Liu, De-Cai Xiong*, Xin-Shan Ye*, “Photo-/Electro-Driven Carbohydrate-Based Reactions”, Prog. Chem. 2020, 32(11), 1804-1823. 13. Qiannan Zheng, Shengbiao Tang, De-Cai Xiong, Qin Li*, and Xin-Shan Ye*, “Carbocyclic Ring Closure of Aryl C-Glycosides Promoted by Fluoroboric Acid”, J. Org. Chem., 2020, 85(14), 9339–9346. 14. Zi-Pei Zhang, Wan-Ying Xue, Jian-Xing Hu, De-Cai Xiong, Yan-Fen Wu*, Xin-Shan Ye*, “Novel carbohydrate-triazole derivatives as potential α-glucosidase inhibitors”, Chin. J. Nat. Med., 2020, 18(10), 729–737. 15. Jing-Jing Sui, De-Cai Xiong,* Xin-ShanYe,* “Copper-mediated O-arylation of lactols with aryl boronic acids”, Chin. Chem. Lett., 2019, 30, 1533-1537. 16. Da-Ke Liu, De-Cai Xiong, Xia Wu, Qin Li,* Xin-Shan Ye,* “Rapid glycosylation of 2′-benzoylphenyl glycosides promoted by TfOH”, Org. Chem. Front., 2019, 6, 2756–2759. 17. Yong-Shi Wang, Yong Wu, De-Cai Xiong, Xin-Shan Ye,* "Total Synthesis of a Hyperbranched N-Linked Hexasaccharide Attached to ATCV-1 Major Capsid Protein without Precedent", Chin. J. Chem., 2019, 37, 42–48. 18. Miao Liu, Bo-Han Li, De-Cai Xiong,* Xin-Shan Ye,* "O-Glycosylation Enabled by Acetamidyl Glycosides", J. Org. Chem., 2018, 83(15), 8292–8303. 19. Gao-Lan Zhang, Meng-Man Wei, Chengcheng Song, Yu-Feng Ma, Xiu-Jing Zheng, De-Cai Xiong, Xin-Shan Ye*,“Chemical synthesis and biological evaluation of penta- to octa- saccharide fragments of Vi polysaccharide from Salmonella typhi”Org. Chem. Front., 2018, 5, 2179–2188. 20. Dong Wang, De-Cai Xiong*, Xin-Shan Ye*, “A five-component one-pot synthesis of phosphatidylinositol pentamannoside (PIM5)”, Chin. Chem. Lett., 2018, 29, 1340-1342. 21. Shengbiao Tang, Qiannan Zheng, De-Cai Xiong,* Shende Jiang, Qin Li, Xin-Shan Ye*, “Stereocontrolled Synthesis of 2-Deoxy-C-Glycopyranosyl Arenes Using Glycals and Aromatic Amines”, Org. Lett. 2018, 20, 3079–3082. 22. Runze Mao, Lifeng Sun, Yong-Shi Wang, Min-Min Zhou, De-Cai Xiong, Qin Li*, and Xin-Shan Ye*, “N-9 Alkylation of purines via light-promoted and metal-free radical relay”, Chin. Chem. Lett., 2018, 29, 61-64. 23. Gao-Lan Zhang, Lin Yang, Jingjing Zhu, Mengman Wei, Wanjun Yan, De-Cai Xiong, Xin-Shan Ye*, “Synthesis and Antigenic Evaluation of Oligosaccharide Mimics of Vi Antigen from Salmonella typhi”, Chem. Eur. J. 2017, 23, 10670-10677. 24. Yong Wu, De-Cai Xiong, Si-Cong Chen, Yong-Shi Wang, Xin-Shan Ye*, “Total synthesis of mycobacterial arabinogalactan containing 92 monosaccharide units”, Nat. Commun. 2017, 8, 14851. 25. Yang Yu, De-Cai Xiong*, Run-Ze Mao, and Xin-Shan Ye*, “Visible Light Photoredox-Catalyzed O-Sialylation Using Thiosialoside Donors”, J. Org. Chem., 2016, 81(16), 7134–7138. 26. Lifeng Sun, Xiaowei Wu, De-Cai Xiong, Xin-Shan Ye*, “Stereoselective Koenigs–Knorr Glycosylation Catalyzed by Urea”, Angew. Chem. Int. Ed., 2016, 55, 8041-8044. 27. Yang Yu+, De-Cai Xiong+ and Xin-Shan Ye*, “2-Trifluoromethylthiolation of Glycals”, Org. Biomol. Chem. 2016, 14, 6403-6406. 28. Run-Ze Mao+, De-Cai Xiong+, Fan Guo, Qin Li, Jinyou Duan and Xin-Shan Ye*，“Light-driven highly efficient glycosylation reactions” Org. Chem. Front., 2016, 3, 737–743. 29. Chen-Fu Liu+, De-Cai Xiong+, Xin-Shan Ye*, “KOtBu-mediated aromatic O-glycosylation of 1,2-anhydrosugar and aryl boronic acid”, Tetrahedron Lett., 2016, 57, 1372-1374. 30. Shengbiao Tang, De-Cai Xiong, Shende Jiang*, and Xin-Shan Ye*， “Nitro- polyols via Pyridine Promoted C═C Cleavage of 2-Nitroglycals. Application to the Synthesis of (−)-Hyacinthacine A1”, Org. Lett. 2016, 18(3), 568–571. 31. Bang Wang, De-Cai Xiong*, and Xin-Shan Ye*, “Direct C-H Trifluoromethylation of Glycals by Photoredox Catalysis”, Org. Lett. 2015, 17(22), 5698–5701. 32. Run-Ze Mao+, Fan Guo+, De-Cai Xiong*, Qin Li, Jinyou Duan, and Xin-Shan Ye*, “Photoinduced C–S Bond Cleavage of Thioglycosides and Glycosylation”, Org. Lett. 2015, 17(22), 5606-5609. 33. Wenming Li, Youhong Niu, De-Cai Xiong, Xiaoping Cao, and Xin-Shan Ye*, “Highly Substituted Cyclopentane-CMP Conjugates as Potent Sialyltransferase Inhibitors”, J. Med. Chem. 2015, 58, 7972–7990. 34. Xuemei Yang+, De-Cai Xiong+, Chengcheng Song, Guihua Tai and Xin-Shan Ye*, “Synthesis of N-dialkylphosphoryl iminosugar derivatives and their immunosuppressive activities”, Org. Biomol. Chem. 2015, 13, 9364-9368. 35. Shao-Tao Bai+, De-Cai Xiong+, Youhong Niu, Yan-Fen Wu*, Xin-Shan Ye*, “Synthesis of novel N-glycoside derivatives via CuSCN-catalyzed reactions and their SGLT2 inhibition activities”, Tetrahedron, 2015, 71, 4909-4919. 36. Yingguo Liu, Xiaxi Li, De-Cai Xiong, Binhan Yu, Xiaoping Pu*, and Xin-Shan Ye*, “Synthetic phenylethanoid glycoside derivatives as potent neuroprotective agents”, Eur. J. Med. Chem., 2015, 95, 313-323. 37. De-Cai Xiong+, Jingjing Zhu+, Ming-Jie Han, Hui-Xin Luo, Cong Wang, Yang Yu, Yuqian Ye, Guihua Tai, and Xin-Shan Ye*, “Rapid Probing of Sialylated Glycoproteinsin vitro and in vivo via Metabolic Oligosaccharide Engineering of Minimal Cyclopropene Reporter”, Org. Biomol. Chem. 2015, 13, 3911-3917. 38. De-Cai Xiong, An-Qi Yang, Yang Yu, and Xin-Shan Ye*, “2-Pyridyl Glycoside: An Alternative Glycosyl Donor in Preactivation Protocol”, Tetrahedron Lett., 2015, 56, 211-214. 39. Qi Qin, De-Cai Xiong, and Xin-Shan Ye*, “Additive-controlled Stereoselective Glycosylations of 2,3-Oxazolidinone Protected Glucosamine or Galactosamine Thioglycoside Donors with Phenols Based on Preactivation Protocol”, Carbohydr. Res., 2015, 403, 104-114. 40. De-Cai Xiong+, Yichuan Zhou+, Yuxin Cui, and Xin-Shan Ye*, “Synthesis of triazolyl-linked polysialic acids”, Tetrahedron 2014, 70, 9405-9412. 41. De-Cai Xiong, Chao Gao, Wenming Li, Yuan Wang, Qin Li, and Xin-Shan Ye*, “Synthesis of 2-Deoxy-C-glycosides via Lewis Acid-Mediated Rearrangement of 2,3-Anhydro-1-thiopyranosides”, Org. Chem. Front., 2014, 1, 798-806. 42. Chen-Fu Liu, De-Cai Xiong, and Xin-Shan Ye*, “‘Ring Opening−Ring Closure’ Strategy for the Synthesis of Aryl C-glycosides”, J. Org. Chem., 2014, 79(2), 4676–4686. 43. Xiaowei Wu, Fu-Yu Zhang, Jingjing Zhu, Chengcheng Song, De-Cai Xiong, Yifa Zhou, Yuxin Cui, and Xin-Shan Ye*, “N-Arylated-Lactam-Type Iminosugars as New Immunosuppressive Agents: Discovery, Optimization, and Biological Evaluation”, Chem. Asian. J. 2014, 9, 2260-2271. 44. Peng Peng, De-Cai Xiong, Xin-Shan Ye*, “Ortho-Methylphenylthioglycosides as glycosyl building blocks for preactivation-based oligosaccharide synthesis”, Carbohydr. Res., 2014, 384, 1-8. 45. Fei-Fei Xu, Yue Wang, De-Cai Xiong, and Xin-Shan Ye*, “Stereoselective Synthesis of the Trisaccharide Moiety of Ganglioside HLG-2”, J. Org. Chem., 2014, 79 (2), 797–802. 46. Ming-Jie Han, De-Cai Xiong, and Xin-Shan Ye*, “Enabling Wittig Reaction on Site-Specific Protein Modification”, Chem. Commun. 2012, 48(90), 11079-11081. 47. Yuan-Yuan Wang, De-Cai Xiong, Qin Li, Yuan Wang, Xin-Shan Ye*, “Syntheses of novel acarviosin analogs with anhydro or unsaturated sugar moieties”, Tetrahedron 2012, 68, 9355-9363. 48. Gen Li, De-Cai Xiong, Xin-Shan Ye*, “Synthesis of a-C-Glycosides by Samarium Diiodide Mediated Coupling of Glycosyl Pyridyl Sulfones with Alkenes”, Synlett 2011, 2410–2414. 49. Chao Gao, De-Cai Xiong, Yuan Wang and Xin-Shan Ye*, “Stereoselective synthesis of 2-deoxy-pyranosides via the Lewis acid-promoted rearrangement of 2,3-anhydrosugars”, J. Chin. Pharm. Sci. 2011, 20(2), 146-150. 50. De-Cai, Xiong, Li-He Zhang and Xin-Shan Ye*, “Bromodimethylsulfonium bromide-silver triflate: A new powerful promoter system for the activation of thioglycosides ”, Adv. Synth. Catal. 2008, 350(11-12), 1696-1700. 51. De-Cai Xiong, Li-He Zhang and Xin-Shan Ye*, “Oxidant-Controlled Heck-Type C-Glycosylation of Glycals with Arylboronic Acids: Stereoselective Synthesis of Aryl 2-Deoxy-C-glycosides”, Org. Lett. 2009, 11(8), 1709-1712.