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Zhu XX,# Yi YL,# Fan ZB,# Liu RW, Chu XD, Wang MY, Zhang JY, Tretyakova, E, Zhang YM, Zhang LH, Zhou DM, Xiao SL.* Novel mono- and multivalent N-acetylneuraminic acid glycoclusters as potential broad-spectrum entry inhibitors for influenza and coronavirus infection. Eur. J. Med. Chem. 2023, 260, 115723
Chen B, Chu X, Liu R, Ma X, Wang M, Zhang J, Jiao P, Gao Q, Ma W, Zhang Y, Zhao C,* Zhou D, Xiao S.* Synthesis of novel pentacyclic triterpenoid derivatives that induce apoptosis in cancer cells through a ROS-dependent, mitochondrial-mediated pathway. Mol. Pharm. 2023, 20, 701-710
Tret'yakova EV,#,* Ma X,# Kazakova OB, Shtro AA, Petukhova GD, Smirnova AA, Xu H, Xiao S. Abietic, maleopimaric and quinopimaric dipeptide Ugi-4CR derivatives and their potency against influenza A and SARS-CoV-2. Nat. Prod. Res. 2023, 37(12), 1954-1960
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周德敏,* 李海伟, 肖苏龙. 中药抗病毒的物质基础, 从五环三萜说开来. 北京大学学报（医学版）, 2022, 54(5), 832-836
Tret'yakova EV,#,* Ma X,# Kazakova OB, Shtro AA, Petukhova GD, Klabukov AM, Dyatlov DS, Smirnova AA, Xu H, Xiao S. Synthesis and evaluation of diterpenic Mannich bases as antiviral agents against influenza A and SARS-CoV-2. Phytochem. Lett. 2022, 51, 91-96
Li H, Wang S, Ma W, Cheng B, Yi Y, Ma X, Xiao S,* Zhang L, Zhou D.* Discovery of pentacyclic triterpenoid PROTACs as a class of effective hemagglutinin protein degraders. J. Med. Chem. 2022, 65(10), 7154-7169.
Liang S,# Ma X,# Li M, Yi Y, Gao Q, Zhang Y, Zhang L, Zhou D, Xiao S.* Novel β-cyclodextrin-based heptavalent glycyrrhetinic acid conjugates: Synthesis, characterization and anti-influenza activity. Front. Chem. 2022, 10, 836955
Chen Y,# Wang X,# Ma X, Liang S, Gao Q, Tretyakova E, Zhang Y, Zhou D, Xiao S.* Facial synthesis and bioevaluation of well-defined OEGylated betulinic acid-cyclodextrin conjugates for inhibition of influenza infection. Molecules, 2022, 27(4), 1163
Yi Y, Ma X, Liu R, Chu X, Li H, Zhang J, Gao Q, Zhang Y, Zhang L, Zhou D, Xiao S.* An attempt to synthesize the two monomers of CDTOH: unexpected NMR and X-ray diffraction crystal analysis. Tetrahedron Lett. 2022, 91, 153638.
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Li H, Sun J, Xiao S,* Zhang L, Zhou D.* Triterpenoid-mediated inhibition of virus-host interaction: Is now the time for discovering viral entry/release inhibitors from nature? J. Med. Chem. 2020, 63 (24), 15371-15388
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Li M, Yuan L,* Chen Y, Ma W, Ran F, Zhang L, Zhou D, Xiao S.* Rhodamine B-based fluorescent probes for molecular mechanism study of the anti-influenza activity of pentacyclic triterpenes. Eur. J. Med. Chem., 2020, 205, 112664.
Xiao S,* Zhou D, Zhang L, Sinaÿ P, Zhang Y.* Preparation of unsymmetrically 2A,3B,6C(F)-trihydroxy-per-O-methylated α-cyclodextrin and NMR analysis. Tetrahedron Lett. 2020, 61(33),152224.
Chen Y#, Wang X#, Zhu Y#, Si L, Zhang B, Zhang Y, Zhang L, Zhou D, Xiao S.* Synthesis of a hexavalent betulinic acid derivative as a hemagglutinin-targeted influenza virus entry inhibitor. Mol. Pharm. 2020, 17(7), 2546-2554
Wang H, Xu R, Liang S, Ran F, Zhang L, Zhang Y, Zhou D, Xiao S.* Selective and facile deacetylation of pentacyclic triterpenoid under methanolic ammonia condition and unambiguous NMR analysis. Chin. Chem. Lett. 2020, 31(2), 333-336
Wang Y,# Li S,# Tian Z, Sun J, Liang S, Zhang B, Bai L, Zhang Y, Zhou X, Xiao S, Zhang Q, Zhang L, Zhang C,* Zhou D.*Generation of a caged lentiviral vector through an unnatural amino acid for photo-switchable transduction. Nucleic Acids Res. 2019,47(19), e114.
Liang S,# Li M,# Yu X, Jin H, Zhang Y, Zhang L, Zhou D, Xiao S.* Synthesis and structure-activity relationship studies of water-soluble β-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents. Eur. J. Med. Chem. 2019, 166, 328-338.
Li H,# Li M,# Xu R,# Wang S, Zhang Y, Zhang L, Zhou D,* Xiao S.* Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates. Eur. J. Med. Chem. 2019, 163, 560-568.
Jiao P, Wang S, Liang S, Li M, Gao Q, Ji D, Chen Y, Li H, Ran F, Zhang Y, Zhang L, Zhou D,* Xiao S.* Facile preparation and characterization of novel oleanane-type triterpene functionalized β-cyclodextrin conjugates. Chin. Chem. Lett. 2019, 30(3), 690-693.
Si L, Meng K, Tian Z, Zhang Z, Soloveva V, Li H, Fu G, Xia Q, Xiao S, Zhang L, Cunningham J. M, Zhou D.* Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalentin viral envelopes. Sci. Adv. 2018, 11(4), eaau8408.
Li M, Li H, Liang S, Tian Z, Zhou D, Xiao S.* Recent progresses of novel anti-influenza entry inhibitors. Sci. Sin. Chim. 2018, 48(11), 589-599.
Zhu X, Xiao S, Zhou D, Sollogoub M, Zhang Y*. Design, synthesis and biological evaluation of water-soluble per-O-methylated cyclodextrin-C60 conjugates as anti-influenza virus agents. Eur. J. Med. Chem. 2018, 146, 194-205
Xiao S,* Tian Z, Wang Y, Si L, Zhang L, Zhou D.* Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives. Med. Res. Rev. 2018, 38(3), 951-976.
Shi Y,# Si L,# Han X,# Fan Z, Wang S, Tian Z, Li M, Sun J, Jin H, Zhang Y, Zhou D, Xiao S.* Synthesis of novel pentacyclic triterpene-Neu5Ac2en derivatives and investigation of their in vitro anti-influenza entry activity. MedChemComm. 2017, 8, 1531-1541
Meng L, Wang Q, Tang T, Xiao S, Zhang L, Zhou D, Yu F.* Design, synthesis and biological evaluation of pentacyclic triterpene dimers as HCV entry inhibitors. Chin. J. Chem. 2017, 35(8), 1322-1328.
Wang W, Zhao Z, Zhang Z, Zhang C, Xiao S, Ye X, Zhang L, Xia Q, Zhou D.* Redirecting killer T cells through incorporation of azido sugars for tethering ligands. Chembiochem. 2017, 18(21), 2082-2086.
Han X,# Si L,# Shi Y, Fan Z, Wang S, Tian Z, Li M, Sun J, Jiao P, Ran F, Zhang Y, Zhou D, Xiao S.* Synthesis and in vitro anti-influenza virus evaluation of novel sialic acid (C-5 and C-9)-pentacyclic triterpene derivatives. Molecules 2017, 22(7), 1018.
Tian Z,# Si L,# Meng K, Zhou X, Zhang Y, Zhou D, Xiao S.* Inhibition of influenza virus infection by multivalent pentacyclic triterpene-functionalized per-O-methylated cyclodextrin conjugates. Eur. J. Med. Chem. 2017, 134, 133-139.
Tian Z, Meng K, Shi Y, Zhang N, Liu X, Jin H, Zhang Y, Zhang L, Zhou D, Xiao S.* Facile preparation of a symmetric hexavalent oleanolic acid/per-O-methylated α-cyclodextrin conjugate with two conformations in solution and unambiguous NMR analysis. Tetrahedron 2017, 73 (17), 2512-2517. （"Front Cover Article"）
Wu S, Yang L, Sun W, Si L, Xiao S, Wang Q, Dechoux L, Thorimbert S, Sollogoub M, Zhou D, Zhang Y. Design, synthesis and biological evaluation of gentiopicroside derivatives as potential antiviral inhibitors. Eur. J. Med. Chem.; 2017, 130, 308-319.
Si L,# Xu H,# Zhou X, Zhang Z, Tian Z, Zhang B, Niu Z, Yao T, Wang Y, Li S, Zhang C, Fu G, Xiao S, Xia Q, Zhang L, Zhou D*. Generation of influenza A viruses as live but replication-incompetent virus vaccines. Science 2016, 354(6316), 1170-1173.
Wu Y, Zhu H, Zhang B, Liu F, Chen J, Wang Y, Wang Y, Zhang Z, Wu L, Si L, Xu H, Yao T, Xiao S, Xia Q, Zhang L, Yang Z, Zhou D.* Synthesis of site-specific radiolabeled antibodies for radioimmunotherapy via genetic code expansion. Bioconjug. Chem. 2016, 27(10), 2460-2468.
Xiao S,* Wang Q, Si L, Zhou X, Zhang Y, Zhang L, Zhou D.* Synthesis and biological evaluation of novel pentacyclic triterpene α-cyclodextrin conjugates as HCV entry inhibitors. Eur. J. Med. Chem. 2016, 124, 1-9.
Han X, Shi Y, Si L, Fan Z, Wang H, Xu R, Jiao P, Meng K, Tian Z, Zhou X, Jin H, Wu X, Chen H, Zhang Y, Zhang L, Xiao S,* Zhou D.* Design, synthesis and biological activity evaluation of novel conjugated sialic acid and pentacyclic triterpene derivatives as anti-influenza entry inhibitors. MedChemComm. 2016, 7, 1932-1945. ("HOT" Article)
Xu H, Wang Y, Lu J, Zhang B, Zhang Z, Si L, Wu L, Yao T, Zhang C, Xiao S, Zhang L, Xia Q,* Zhou D.* Re-exploration of the codon context effect on amber codon-guided incorporation of non-canonical amino acids in E. coli by the blue-white screening assay. Chembiochem. 2016, 17, 1-12.
Yu F,* Wang Q, Wang H, Si L, Liu J, Han X, Xiao S, Zhang L, Zhou D.* Synthesis and biological evaluation of echinocystic acid derivatives as HCV entry inhibitors. Chin. Chem. Lett. 2016, 27, 711-713.
Han Wang,# Renyang Xu,# Yongying Shi, Longlong Si, Pingxuan Jiao, Zibo Fan, Xu Han, Xingyu Wu, Xiaoshu Zhou, Fei Yu, Yongmin Zhang, Lihe Zhang, Demin Zhou*, Sulong Xiao*. Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors. Eur. J. Med. Chem. 2016, 110, 376-388.
俞飞,* 郑永祥, 彭逸云, 周德敏, 肖苏龙*. 齐墩果酸A环及C环内酯衍生物的设计合成. 有机化学. 2016, 36, 512-519.
Sulong Xiao,* Longlong Si, Zhenyu Tian, Pingxuan Jiao, Zibo Fan, Kun Meng, Xiaoshu Zhou, Han Wang, Renyang Xu, Xu Han, Ge Fu,Yongmin Zhang, Lihe Zhang, Demin Zhou*. Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effect. Biomaterials. 2016, 78, 74-85.
肖苏龙,* 王晗, 王琪, 韩旭, 徐仁洋, 孟坤, 田振宇, 张礼和, 周德敏.* 基于五环三萜先导结构的抗病毒抑制剂研究进展. 中国科学（化学）. 2015, 45(9), 865-883.
Han Wang,# Fei Yu,# Yiyun Peng, Qi Wang, Xu Han, Renyang Xu, Xiaoshu Zhou, Chuanxing Wan, Zibo Fan, Pingxuan Jiao, Yongmin Zhang, Lihe Zhang, Demin Zhou, Sulong Xiao.* Synthesis and biological evaluation of ring A and/or C expansion and opening echinocystic acid derivatives for anti-HCV entry inhibitors. European Journal of Medicinal Chemistry. 2015, 102, 594-599
Zheng Yongxiang, Yu Fei, Wu Yiming, Si Longlong, Xu Huan, Zhang Chuanling, Xia Qing, Xiao Sulong, Wang Qi, He Qiuchen, Chen Peng, Wang Jiangyun, Zhang Lihe, Taira Kazunari, Zhou Demin.* Broaden the versatility of lentiviral vector as a tool in nucleic acid research via genetic code expansion. Nucleic Acids Res., 2015, 43(11),:e73
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