李勤 - 北京大学

个人简介

1986.8-1991.7 理学学士，北京医科大学药学院化学专业 1991.8-1996.7 助教，北京医科大学药学院有机化学教研室 1996.8-1998.7 讲师，北京医科大学药学院有机化学教研室 1998.8-2001.7 理学博士，北京大学药学院化学生物学系，导师：程铁明教授 2001.08-2007.07讲师，北京大学药学院天然药物及仿生药物国家重点实验室 2007.08-至今副教授，北京大学药学院天然药物及仿生药物国家重点实验室

研究领域

有机小分子药物结构解析用核磁共振方法研究小分子药物溶液构像及小分子药物与生物大分子之间的相互作用基于糖的化学及化学生物学研究

近期论文

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1. Shengbiao Tang, Qiannan Zheng, De-Cai Xiong,* Shende Jiang, Qin Li, Xin-Shan Ye*, “Stereocontrolled Synthesis of 2-Deoxy-C-Glycopyranosyl Arenes Using Glycals and Aromatic Amines”, Org. Lett. 2018, 20, 3079–3082. 2. Runze Mao, Lifeng Sun, Yong-Shi Wang, Min-Min Zhou, De-Cai Xiong, Qin Li*, and Xin-Shan Ye*, “N-9 Alkylation of purines via light-promoted and metal-free radical relay”, Chin. Chem. Lett., 2018, 29, 61-64. 3. Zhuo Lv, Chengcheng Song, Youhong Niu, Qin Li,* and Xin-Shan Ye*, “Synthesis of N-Substituted Iminosugar Derivatives and Evaluation of Their Immunosuppressive Activities”, ChemMedChem 2018, 13, 338 –351. 4. Hai-Qian Liu, Cheng-Cheng Song, You-Hong Niu, Tao Li, Qin Li* and Xin-Shan Ye*, “Synthesis and biological evaluation of N-arylated-lactam-type iminosugars as potential immunosuppressive agents”, Org. Biomol. Chem., 2017, 15, 5912-5919. 5. Shuang Sun, Xiu-Jing Zheng, Chang-Xin Huo, Chengcheng Song, Qin Li*, and Xin-Shan Ye*, “Synthesis and evaluation of Glycoconjugates Comprising N-acetyl modified Thomsen-Friedenreich antigens as anticancer vaccines”, ChemMedChem 2016, 11, 1090-1096. 6. Run-Ze Mao+, De-Cai Xiong+, Fan Guo, Qin Li, Jinyou Duan and Xin-Shan Ye*， “Light-driven highly efficient glycosylation reactions”, Org. Chem. Front., 2016, 3, 737–743. 7. Run-Ze Mao+, Fan Guo+, De-Cai Xiong*, Qin Li, Jinyou Duan, and Xin-Shan Ye*, “Photoinduced C–S Bond Cleavage of Thioglycosides and Glycosylation”, Org. Lett. 2015, 17(22), 5606-5609. 8. Qin Li and Xin-Shan Ye*, “Iminosugars as Immunomodulating Agents: Synthesis and Biological Activities of 1-Deoxynojirimycin and Related Compounds”, Israel J. Chem., 2015, 55, 336-346. 9. Shuang Sun, Yanyan Liu, Yafei Cao, Youhong Niu, Qin Li*, Xin-Shan Ye*, “Synthesis of N(OMe)-linked TF antigen analogue”. J. Chin. Pharm. Sci. 2015, 24, 356-363. 10. De-Cai Xiong, Chao Gao, Wenming Li, Yuan Wang, Qin Li, and Xin-Shan Ye*, “Synthesis of 2-Deoxy-C-glycosides via Lewis Acid-Mediated Rearrangement of 2, 3-Anhydro-1-thiopyranosides”, Org. Chem. Front., 2014, 1, 798-806. 11. Junfeng Wang, Qin Li*, Zemei Ge, Runtao Li*, “A versatile and convenient route to ketone C-pyranosides and ketone C-furanosides from unprotected sugars”, Tetrahedron, 2012, 68, 1315-1320. 12. Yuan-yuan Wang, De-cai Xiong, Qin Li, Yuan Wang, Xin-shan Ye*, “Synthesis of novel acarviosin analogs with anhydro or unsaturated sugar moieties Tetrahedron 2012,68,9355-9363. 13. Yin-Suo Lu, Qin Li, Yuan Wang, Xin-Shan Ye*, “Direct a-selective glycosylations of acetyl-protected 2-deoxy- and 2, 6-dideoxythioglycosides by preactivation protocol”, SYNLETT, 2010, 10, 1519-1524. 14. Junfeng Wang, Qin Li, Chao Qi, Yi Liu, Zemei Ge and Runtao Li*, “Primary 1, 2-diamine catalysis III: an unexpected domino reaction for the synthesis of multi-substituted cyclohexa-1,3-dienamines”, Org. Biomol. Chem. 2010, 8, 4240-4242. 15. Qin Li, Guichun Lin, Li Liu, Zhenjun Yang* and Li-He Zhang, “Methyl carbonium ion migration during the reaction of 4-Chloro-5-methoxyl-3(2H)-pyridazinone with trifluoroethylation agents”, Molecules, 2009, 14, 777-784. 16. Yin-Suo Lu, Qin Li, Li-He Zhang, Xin-Shan Ye*,“ Highly direct a-selective glycosylations of 3,4-O-carbonate-protected 2-deoxy- and 2,6-dideoxythioglycosides by preactivation protocol”, Org. Lett. 2008, 10(16), 3445-3448. 17. Li Cai, Qin Li, Bo Ren, Zhen-Jun Yang*, Liang-Ren Zhang, Li-He Zhang, “Synthesis of aminodisaccharide-nucleoside conjugates for RNA binding”, Tetrahedron, 2007, 63, 8135-8144. 18. Ming Zhao, Xin Jia, Chao Wang, Qin Li,Kexiang Zhou, Lili Wang, Hu Liu, Shiqi Peng, “PAK: an essential motif for forming beta-turn structures and exhibiting the thrombolytic effect of P6A and its analogs”, Biochem Cell Biol. 2007 ,85,730-740. 19. Qiu-Hua Fan, Nanting Ni, Qin Li, Li-He Zhang, Xin-Shan Ye*, “New one-carbon degradative transformation of b-alkyl-b-azido alcohols”, Org. Lett. 2006, 8, 1007-1009. 20. Changning Wang, Qin Li, Haisheng Wang, Li-He Zhang and Xin-Shan Ye*, “A new one-pot synthesis of Gb3 and isoGb3 trisaccharide analogues”, Tetrahedron 2006, 62 , 11657-11662. 21. 杨春晖,陈静文,李勤,彭昆,潘鑫复,崔育新, “NMR确定手性α-羟基酮的绝对构型” 高等学校化学学报, 2006, 27, 1295-1297. 22. Feng Niu, Zheng Cui, Qin Li, Chang, Haitao, Yong Jiang, Liang Qiao, Peng-fei Tu*, “Complete assignments of H-1 and C-13 NMR spectral data for a novel diterpenoid from Semiaquilegia adoxoides”, Magn. Reson. Chem. 2006, 44, 724-726 23. Qin Li, Qiu-Hua Fan, Li-He Zhang, Xin-Shan Ye*, “Selective reduction of azido groups in monosaccharides with triphenylphosphine”, SYNLETT, 2006, 15, 2464-2468. 24. Qin Li, Chunhui Yang, Zemei Ge, Runtao Li, Yuxin Cui*,“Structure elucidation of a novel group of dithiocarbamate derivatives using 1D and 2D NMR spectroscopy”, Magn. Reson. Chem. 2006, 44, 720-723. 25. Yuan Wang, Qin Li, Shuihong Cheng, Yanfen Wu, Dongjie Guo, Qiu-Hua Fan, Xiaofang Wang, Li-He Zhang, and Xin-Shan Ye*, “ Base-promoted rearrangement of sugar epoxides to unsaturated sugars”, Org. Lett. 2005, 7(25), 5577-5579. 26. Jian Hu, Xin Jia*，Qin Li， Xiaoda Yang*, and Kui Wang, “Binding of La3+ 头Calmodulin and its Effecrs on the Interaction between Calmodulin and Calmodulin Binding Peptide, Polistes Mastoparan”, Biochemistry, 2004, 43, 2688-2698. 27. Qin Li, Hui Li, Qing Li, Qing-Hua Lou, Bin Su, Meng-Sen Cai, Zhong-Jun Li*, “Synthesis of a spacer-armed disulfated tetrasaccharide of SB1a, a carbohydrate hapten associated with human hepatocellular carcinoma”, Carbohydr. Res. 2002, 337, 1929-1934.