梁磊 - 北京大学

个人简介

学习经历 2000.9-2004.7 四川大学化学学院（理学学士） 2004.9-2009.7 四川大学&伊利诺依大学厄巴纳—香槟分校（联合培养博士）工作经历 2009.7-2011.6 北京大学化学与分子工程学院（博士后） 2011.7-2014.7 北京大学药学院讲师 2014.8-至今北京大学药学院副教授，硕士生导师 2018.10-2019.10 斯坦福大学医学院访问学者

研究领域

1. 分子探针的设计及其在疾病早期诊断中的应用 2. 基于蛋白结构的荧光探针构建与中药药效物质的发现 3. 药物设计、合成与构效关系研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Tongliang Zhou, Junda Wang, Jiamin Xu, Cangxin Zheng, Yan Niu, Chao Wang, Fengrong Xu, Lan Yuan, Xin Zhao,* Lei Liang,* Ping Xu,* A Smart Fluorescent Probe for NO Detection and Application in Myocardial Fibrosis Imaging. Analytical Chemistry 2020, https://doi.org/10.1021/acs.analchem.9b05435. 2. Hongyue Li, Dandan Xi, Yan Niu, Chao Wang, Fengrong Xu, Lei Liang,* Ping Xu,* Design, synthesis and biological evaluation of cobalt(II)-Schi？ base complexes as ATP-noncompetitive MEK1 inhibitors. Journal of Inorganic Biochemistry 2019, 195, 174-181. 3. Tongliang Zhou, Lingfei Yang, Lei Liang,* Hui Liu, Yuanjun Zhu,* Mengyang Shui, Lan Yuan,* Fengrong Xu, Yan Niu, Chao Wang, Ping Xu,* Rational Design of a Near-infrared Fluorescent Probe Based on Pyridazinone Scaffold. Eur. J. Org. Chem., 2017, 3274-3281. 4. Yuanjun Zhu, Tongliang Zhou, Lingfei Yang, Lan Yuan, Lei Liang,* Ping Xu,* Revelation of the dynamic progression of hypoxia-reoxygenation injury by visualization of the lysosomal hydrogen peroxide. Biochem & Biophy Res. Comm., 2017, 486, 904-908. 5. Hongyue Li, Tongliang Zhou, Hui Liu, Fengrong Xu, Yan Niu, Chao Wang, Lei Liang,* Ping Xu,* Discovery of a cobalt complex with high MEK1 binding affinity. Bioorg. Med. Chem. Lett., 2017, 27, 2221-2224. 6. Tongliang Zhou, Yuanbo Cai, Lei Liang,* Lingfei Yang, Fengrong Xu, Yan Niu, Chao Wang, Junlong Zhang,* Ping Xu,* Discovery of a potent and highly specific beta(2) proteasome inhibitor from a library of copper complexes. Bioorg. Med. Chem. Lett., 2016, 26, 5780-5784. 7. Lingfei Yang, Yuanjun Zhu, Mengyang Shui, Tongliang Zhou, Yuanbo Cai, Wei Wang, Fengrong Xu, Yan Niu, Chao Wang, Jun-Long Zhang, Ping Xu,* Lan Yuan,* and Lei Liang,* Rational design of fluorescent phthalazinone derivatives for one- and two-photon imaging. Chem. Eur. J., 2016, 22, 12363-12370. 8. Lingfei Yang, Wei Wang, Qi Sun, Fengrong Xu, Yan Niu, Chao Wang, Lei Liang,* Ping Xu,* Development of novel proteasome inhibitors based on phthalazinone scaffold. Bioorg. Med. Chem. Lett., 2016, 26, 2801-2805. 9. Wei Wang, Lei Liang,* Fengrong Xu, Wenjie Huang, Yan Niu, Qi Sun, Ping Xu,* Ruthenium-Catalyzed Switchable N–H/C–H Alkenylation of 6-Phenyl(dihydro)pyridazinones with Alkynes. Eur. J. Org. Chem. 2014, 6863–6867. 10. Lei Liang, Wei Wang, Jun Wu, Fengrong Xu, Yan Niu, Bo Xu*, Ping Xu*, Rational Design, Green Synthesis, and Initial Evaluation of a Series of Full-Color Tunable Fluorescent Dyes Enabled by the Copper-Catalyzed N-Arylation of 6-Phenyl Pyridazinones and Their Application in Cell Imaging. Chem. Eur. J., 2013, 19, 13774-13782. 11. Lei Liang, Wei Wang, Fengrong Xu, Yan Niu, Qi Sun, Ping Xu*, Relay Catalysis by a Multifunctional Cu Catalyst in a Tandem Dehydro-/Dehalogenation Sequence along with N-Arylation. Org. Lett., 2013, 15, 2770-2773. 12. Lei Liang, Guanyu Yang, Fengrong Xu, Yan Niu, Qi Sun, Ping Xu*, A Copper-Catalyzed Aerobic Cascade Dehydrogenative Dehalogenative Reaction. Adv. Syn&Cat., 2013, 355, 1284-1290. 13. Lei Liang, Guanyu Yang, Fengrong Xu, Yan Niu, Qi Sun, Ping Xu*, Copper-Catalyzed Aerobic Dehydrogenation of C–C to C=C Bonds in the Synthesis of Pyridazinones. Eur. J. Org. Chem., 2013, 6130–6136.