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Zirui Lü, Xiaona Li, Kebin Li, Paola Ripani, Xiaomeng Shi, Fengrong Xu, Mopei Wang, Liangren Zhang, Thomas Brunner, Ping Xu* and Yan Niu*, Nitazoxanide and related thiazolides induce cell death in cancer cells by targeting the 20S proteasome with novel binding modes. Biochem Pharmacol . 2022, 197:114913.
Xiaona Li, Zirui Lü, Cong Wang, Kebin Li, Fengrong Xu, Ping Xu*, and Yan Niu*, Induction of Apoptosis in Cancer Cells by Glutathione Transferase Inhibitor Mediated Hydrophobic Tagging Molecules, ACS Med Chem Lett , 2021, 12(5): 720-725
Zirui Lü, Xiaona Li, Kebin Li, Cong Wang, Tingting Du, Wei Huang, Ming Ji, Changhong Li, Fengrong Xu, Ping Xu*, and Yan Niu*，Structure–Activity Study of Nitazoxanide Derivatives as Novel STAT3 Pathway Inhibitors, ACS Med Chem Lett , 2021, 12(5):696-703
Sun Q, Zhou T, Xi D, Li X, LüZ, Xu F, Wang C, Niu Y*, Xu P.*，Design and synthesis of tripeptidyl furylketones as selective inhibitors against the β5 subunit of human 20S proteasome. Eur J Med Chem . 2020,192: 112160. https://doi.org/10.1016/j.ejmech.2020.112160
Dandan Xi, Yan Niu*, Hongyue Li, Stefan M. Noha, Veronika Temml, Daniela Schuster*, Chao Wang, Fengrong Xu, and Ping Xu*, Discovery of carbazole derivatives as novel allosteric MEK inhibitors by pharmacophore modeling and virtual screening, Eur J Med Chem , 2019, 178: 802-817, https://doi.org/10.1016/j.ejmech.2019.06.027
Jing Sun, Yan Niu*, Chao Wang, Hao Zhang, Bingyu Xie, Fengrong Xu, Hongwei Jin, Yihong Peng, Lei Liang, Ping Xu*, Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents, Bioorg Med Chem , 2016, 24: 3472–3482
Chang-hong Li, Zi-rui Lü, Zhen-da Zhao, Xin-yu Wang, Hui-jie Leng*, Yan Niu* and Mo-pei Wang*, Nitazoxanide, an Antiprotozoal Drug, Reduces Bone Loss in Ovariectomized Mice by Inhibition of RANKL-Induced Osteoclastogenesis, Frontiers in Pharmacology , 2021, 12: 781640, doi: 10.3389/fphar.2021.781640
P. Ripani, J. Delp, K. Bode, M. E. Delgado, L. Dietrich, V. M. Betzler, N. Yan, G. von Scheven, T. U. Mayer, M. Leist & T. Brunner*, Thiazolides promote G1 cell cycle arrest in colorectal cancer cells by targeting the mitochondrial respiratory chain, Oncogene , 2020, 39: 2345–2357.
Xiufeng Xu, Peng Lü, Junjie Wang, Fengrong Xu, Lei Liang, Chao Wang, Yan Niu*, and Ping Xu*, Design, synthesis, and biological evaluation of 4-aminopyrimidine or 4,6-diaminopyrimidine derivatives as beta amyloid cleaving enzyme-1 inhibitors, Chem. Biol. Drug Des. , 2019, 93(5): 926-933. doi: 10.1111/cbdd.13489.
Gang Yan, Lina Hao, Yan Niu*, Wenjie Huang, Wei Wang, Fengrong Xu, Lei Liang, Chao Wang, Hongwei Jin, Ping Xu*, 2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies, Eur J Med Chem , 2017, 137: 462–475
Qi Sun, Bo Xu, Yan Niu*, Fengrong Xu, Lei Liang, Chao Wang, Jiapei Yu, Gang Yan, Wei Wang, Hongwei Jin*, Ping Xu*. Synthesis, Bioactivity, Docking and Molecular Dynamics Studies of Furan-Based Peptides as 20S Proteasome Inhibitors. ChemMedChem , 2015, 10, 498–510.
Peng Liu, Yan Niu*, Chao Wang, Qi Sun, Yaya Zhai, Jiapei Yu,Jing Sun, Fengrong Xu, Gang Yan, Wenjie Huang, Lei Liang, Ping Xu*, 4-Oxo-1,4-dihydroquinoline-3-carboxamides as BACE-1 inhibitors: synthesis, biological evaluation and docking studies, Eur J Med Chem. 2014, 79: 413- 421.
Chao Wang, Hao Zhang, Fengrong Xu, Yan Niu*, Yun Wu, Xin Wang, Yihong Peng, Jing Sun, Lei Liang and Ping Xu*, Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents, Molecules , 2013, 18, 6057-6091.
Yan Niu, Haifei Gao, Fengrong Xu, Lei Liang, Peng Liu, Chao Wang, Guanyu Yang, Qi Sun, Ping Xu*, Design, synthesis and in vitro biological evaluation of 3-styrylbenzimidamides as potential BACE1 inhibitors, Letters in Drug Design & Discovery , 2013, 10 ( 4 ): 297-302
Yan Niu, Haifei Gao, Fengrong Xu, Chao Wang, Peng Liu, Guanyu Yang, Qi Sun, Ping Xu*, Synthesis, in vitro biological evaluation and molecular docking studies of benzimidamides as potential BACE1 inhibitors, Chem Biol Drug Des , 2012, 80: 775–780
Yan Niu, Chao Ma, Hongwei Jin, Fengrong Xu, Haifei Gao, Peng Liu, Yongjian Li, Chao Wang, Guanyu Yang and Ping Xu*, The Discovery of Novel b-Secretase Inhibitors: Pharmacophore Modeling, Virtual Screening, and Docking Studies, Chem Biol Drug Des , 2012, 79:972-80
Dong Wang, Liguo Yang, Jingjing Su, Yan Niu, Xiaoping Lei, Juan Xiong, Xiaohua Cao, Yinghe Hu, Bing Mei, Jin-Feng Hu, Attenuation of neurodegenerative phenotypes in Alzheimer-like presenilin1/presenilin 2 conditional double knockout mice by EUK1001, a promising derivative of xanomeline, Biochemical and Biophysical Research Communications , 2011, 410: 229–234
Yan Niu, Yuehua Wang, Xiaomin Zou, Xiaoming Yang, Chao Ma, Yang Lü, Bo Zhou, Yue Yuan, Guanhua Du and Ping Xu*. Synthesis and preliminary evaluation of peptidomimetic inhibitors of human β-secretase. European Journal of Medicinal Chemistry. 2010, 45: 2089–2094
Wen Si, Xuliang Zhang, Yan Niu, Huiting Yu, Xiaoping Lei, Huanxin Chen, Xiaohua Cao, A novel derivative of xanomeline improves fear cognition in aged mice, Neuroscience Letters , 2010, 473: 115–119
Yihui Cui, Dong Wang, Wen Si, Wen Lu, Yan Niu, Xiaoping Lei, Yinhe Hu, Xiaohua Cao*, Enhancement of memory function in aged mice by a novel derivative of xanomeline, Cell Research , 2008: 1-3
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