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Tingting Lou#, Annan Li#, Houchao Xu#, Jingfeng Pan#, Baiying Xing, Ruibo Wu*, Jeroen S. Dickschat*, Donghui Yang*, and Ming Ma*. Structural insights into three sesquiterpene synthases for the biosynthesis of tricyclic sesquiterpenes and chemical space expansion by structure-based mutagenesis. J. Am. Chem. Soc., 2023, 145, 8474–8485. (https://doi.org/10.1021/jacs.3c00278)
Changbiao Chi, Run Xu, Qianqian Chen, Xiaohui Zhang, Xiaomeng Shi, Hongwei Jin, Fuling Yin, Hongli Jia, Liangren Zhang, Donghui Yang, Jianhua Ju, Qinglian Li*, and Ming Ma*. Structural insight into a metal-dependent mutase revealing an arginine residue-covalently mediated interconversion between nucleotide-based pyranose and furanose. ACS Catal., 2023, 13, 1597–1603. (https://doi.org/10.1021/acscatal.2c04907)
Xueyang Ma#, Zhijun Tang#, Wenping Ding, Tan Liu, Donghui Yang, Wen Liu*, and Ming Ma*. Structure-based mechanistic insights into ColB1, a flavoprotein functioning in trans in the 2,2ʹ-bipyridine assembly line for cysteine dehydrogenation. ACS Chem. Biol., 2023, 18, 18–24. (https://doi.org/10.1021/acschembio.2c00785)
Ning Shao#, Xueyang Ma#, Ying-Ying Zhang#, Donghui Yang, Ming Ma*, Gong-Li Tang*. Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis. Acta Pharm. Sin. B., 2023, 13, 1318–1325. (https://doi.org/10.1016/j.apsb.2022.10.005)
Bidhan Chandra De#, Wenjun Zhang#, Chunfang Yang, Attila Mándi, Chunshuai Huang, Liping Zhang, Wei Liu, Mark W Ruszczycky, Yiguang Zhu, Ming Ma, Ghader Bashiri, Tibor Kurtán, Hung-Wen Liu*, Changsheng Zhang*. Flavin-enabled reductive and oxidative epoxide ring opening reactions. Nat. Commun., 2022, 13, 4896. (https://doi.org/10.1038/s41467-022-32641-1)
Baiying Xing#, Houchao Xu#, Annan Li, Tingting Lou, Meng Xu, Kaibiao Wang, Zhengren Xu, Jeroen S. Dickschat*, Donghui Yang*, and Ming Ma*. Crystal structure based mutagenesis of cattleyene synthase leads to the generation of rearranged polycyclic diterpenes. Angew. Chem. Int. Ed., 2022, 61, e202209785. (https://doi.org/10.1002/anie.202209785) (selected as "Very Important Paper")
Jiahui Yu#, Juan Song#, Changbiao Chi, Tan Liu, Tongtong Geng, Zonghui Cai, Weidong Dong, Cheng Shi, Xueyang Ma, Zhongyi Zhang, Xiaojie Ma, Baiying Xing, Hongwei Jin, Liangren Zhang, Suwei Dong, Donghui Yang, and Ming Ma*. Functional characterization and crystal structure of the bifunctional thioesterase catalyzing epimerization and cyclization in skyllamycin biosynthesis. ACS Catal., 2021, 11, 11733–11741. (https://doi.org/10.1021/acscatal.1c03064)
Baiying Xing#, Jiahui Yu#, Changbiao Chi, Xueyang Ma, Qingxia Xu, Annan Li, Yuanjie Ge, Zhengdong Wang, Tan Liu, Hongli Jia, Fuling Yin, Juan Guo, Luqi Huang, Donghui Yang*, and Ming Ma*. Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis. Commun. Chem., 2021, 4, 140. (https://doi.org/10.1038/s42004-021-00578-z)
Tan Liu#, Xiaojie Ma#, Jiahui Yu, Wensheng Yang, guiyang wang, Zhengdong Wang, Yuanjie Ge, Juan Song, Hua Han, Wen Zhang, Donghui Yang, Xuehui Liu* and Ming Ma*. Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications. Chem. Sci., 2021, 12, 12353-12364. (https://doi.org/10.1039/D1SC02695J)
Bochuan Yuan#, Ziwei Wu#, Wei Ji, Dong Liu, Xiang Guo, Donghui Yang, Aili Fan, Hongli Jia, Ming Ma*, Wenhan Lin*. Discovery of cyclohexadepsipeptides with anti-Zika virus activities and biosynthesis of the nonproteinogenic building block (3S)-methyl-L-proline. J. Biol. Chem., 2021, 297, 100822. ("Editors' Picks" Research Article) (https://doi.org/10.1016/j.jbc.2021.100822) (This article was highlighted and commented by J. Biol. Chem., 2021, 297, 101047. https://doi.org/10.1016/j.jbc.2021.101047)
Wenjuan Ding, Changbiao Chi, Xiaoyi Wei, Changli Sun, Jiajia Tu, Ming Ma, Qinglian Li*, Jianhua Ju*. Enzymatic synthesis of a diastereomer of neoabyssomicin derivative using the Diels-Alderase AbyU. Chin. J. Chem., 2021, 39, 1871-1877. (https://doi.org/10.1002/cjoc.202100081)
Hua Xiao#, Guiyang Wang#, Zhengdong Wang, Yi Kuang, Juan Song, Jing Jin, Min Ye, Donghui Yang*, Ming Ma*. Generation of unusual aromatic polyketides by incorporation of phenylamine analogues into a C-ring-cleaved angucyclinone. Molecules, 2021, 26, 1959. (https://doi.org/10.3390/molecules26071959)
Changbiao Chi#, Zhengdong Wang#, Tan Liu, Zhongyi Zhang, Huan Zhou, Annan Li, Hongwei Jin, Hongli Jia, Fuling Yin, Donghui Yang, Ming Ma*. Crystal structures of Fsa2 and Phm7 catalyzing [4 + 2] cycloaddition reactions with reverse stereoselectivities in equisetin and phomasetin biosynthesis. ACS Omega, 2021, 6, 12913-12922. (https://doi.org/10.1021/acsomega.1c01593)
Yuanjie Ge#, Guiyang Wang#, Jing Jin, Tan Liu, Xueyang Ma, Zhongyi Zhang, Tongtong Geng, Juan Song, Xiaojie Ma, Yingtao Zhang, Donghui Yang,* and Ming Ma*. Discovery and biosynthesis of pepticinnamins G-M featuring three enzymes-catalyzed nonproteinogenic amino acid formation. J. Org. Chem., 2020, 85, 8673-8682. (https://doi.org/10.1021/acs.joc.0c01113)
Xiaoxu Sun, Guiyang Wang, Hua Xiao, Jingyi Jiang, Dongliang Xiao, Baiying Xing, Annan Li, Yingtao Zhang, Kai Sun, Yuquan Xu, Lanping Guo, Donghui Yang*, and Ming Ma*. Strepimidazoles A-G from the plant endophytic Streptomyces sp. PKU-EA00015 with inhibitory activities against a plant pathogenic fungus. J. Nat. Prod., 2020, 83, 2246-2254. (https://doi.org/10.1021/acs.jnatprod.0c00362)
Qinglian Li*, Wenjuan Ding, Jiajia Tu, Changbiao Chi, Hongbo Huang, Xiaoqi Ji, Ziwei Yao, Ming Ma, Jianhua Ju*. Nonspecific heme-binding cyclase, AbmU, catalyzes [4+2] cycloaddition during neoabyssomicin biosynthesis. ACS Omega, 2020, 5, 20548-20557. (https://doi.org/10.1021/acsomega.0c02776)
Bochuan Yuan, Dong Liu, Xin Guan, Yunchen Yan, Jianping Zhang, Yiping Zhang, Donghui Yang, Ming Ma*, Wenhan Lin*. Piperazine ring formation by a single-module NRPS and cleavage by an α-KG-dependent nonheme iron dioxygenase in brasiliamide biosynthesis. Appl. Microbiol. Biotechnol., 2020, 104, 6149-6159. (https://doi.org/10.1007/s00253-020-10678-w)
Xueyang Ma#, Guiyang Wang#, Tan Liu, Changbiao Chi, Zhongyi Zhang, Donghui Yang, Wen Liu*, Ming Ma*. The functional characterization and crystal structure of type II peptidyl carrier protein ColA1a in collismycins biosynthesis. Chin. J. Chem., 2020, 38, 963-969. (https://doi.org/10.1002/cjoc.202000108)
Changdong He, Shuang Wu, Dangliang Liu, Changbiao Chi, Weilin Zhang, Ming Ma, Luhua Lai, Suwei Dong*. Glycopeptide Self-Assembly Modulated by Glycan Stereochemistry through Glycan-Aromatic Interactions. J. Am. Chem. Soc., 2020, 142, 17015-17023. (https://doi.org/10.1021/jacs.0c06360)
Meng Zhang#, Fu-Dong Li#, Kai Li#, Zi-Long Wang, Yu-Xi Wang, Jun-Bin He, Hui-Fei Su, Zhong-Yi Zhang, Chang-Biao Chi, Xiao-Meng Shi, Cai-Hong Yun, Zhi-Yong Zhang, Zhen-Ming Liu, Liang-Ren Zhang, Dong-Hui Yang, Ming Ma*, Xue Qiao*, Min Ye*. Functional characterization and structural basis of an efficient di-C-glycosyltransferase from Glycyrrhiza glabra. J. Am. Chem. Soc., 2020, 142, 3506-3512. (https://doi.org/10.1021/jacs.9b12211)
Tan Liu#, Jing Jin#, Xiaoyan Yang, Juan Song, Jiahui Yu, Tongtong Geng, Zhongyi Zhang, Xueyang Ma, Guiyang Wang, Hua Xiao, Yuanjie Ge, Xiaoxu Sun, Baiying Xing, Xiaojie Ma, Changbiao Chi, Yi Kuang, Min Ye, Hailong Wang, Youming Zhang, Donghui Yang*, and Ming Ma*. Discovery of a phenylamine-incorporated angucyclinone from marine Streptomyces sp. PKU-MA00218 and generation of derivatives with phenylamine analogues. Org. Lett., 2019, 21, 2813-2817. (https://doi.org/10.1021/acs.orglett.9b00800)
Mengjie Zhou, Fawang Liu, Xiaoyan Yang, Jing Jin, Xin Dong, Ke-Wu Zeng, Dong Liu, Yingtao Zhang, Ming Ma*, Donghui Yang*. Bacillibactin and bacillomycin analogues with cytotoxicities against human cancer cell lines from marine Bacillus sp. PKU-MA00093 and PKU-MA00092. Mar. Drugs, 2018, 16, 22. (https://doi.org/10.3390/md16010022)
Jing Jin#, Xiaoyan Yang#, Tan Liu#, Hua Xiao, Guiyang Wang, Mengjie Zhou, Fawang Liu, Yingtao Zhang, Dong Liu, Minghua Chen, Wei Cheng, Donghui Yang*, Ming Ma*. Fluostatins M-Q featuring a 6-5-6-6 ring skeleton and high oxidized A-rings from marine Streptomyces sp. PKU-MA00045. Mar. Drugs, 2018, 16, 87. (https://doi.org/10.3390/md16030087)
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